PDB
7YMJ
Resolution
3.4 Å
Released
July 5, 2023
Receptor
α1A
Class
A
Species
Homo sapiens
Ligand
tamsulosin
Function
Antagonist
Reference
10.1038/S41467-023-39310-X

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Ligand Amino Acid Generic Number Segment Interaction Type
tamsulosin F86 2.64x63 TM2 hydrophobic
tamsulosin W102 3.28x28 TM3 aromatic (edge-to-face)
tamsulosin D106 3.32x32 TM3 polar (charge-assisted hydrogen bond)
tamsulosin V107 3.33x33 TM3 hydrophobic
tamsulosin V107 3.33x33 TM3 Van der Waals
tamsulosin C110 3.36x36 TM3 Van der Waals
tamsulosin C176 45.50x50 ECL2 polar (hydrogen bond with backbone)
tamsulosin C176 45.50x50 ECL2 Van der Waals
tamsulosin F288 6.51x51 TM6 hydrophobic
tamsulosin F288 6.51x51 TM6 Van der Waals
tamsulosin F289 6.52x52 TM6 Van der Waals
tamsulosin F289 6.52x52 TM6 aromatic (edge-to-face)
tamsulosin M292 6.55x55 TM6 Van der Waals
tamsulosin F312 7.39x38 TM7 hydrophobic
tamsulosin F312 7.39x38 TM7 Van der Waals
tamsulosin Y316 7.43x42 TM7 Van der Waals

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ICL1 R H L H ICL1ECL1 Y W A F ECL1ICL2 P L R Y P T I V ICL2ECL2 R Q P A P E D E T I C Q I N E ECL2ICL3 K T D K S D S E Q V T L R I H R K N A P A G G S G M A S A K T K T H F S V R ICL3ECL3 P D F K P ECL3N-term M V F L S G N A S D S S N C T Q P P A N-termC-term I Q C L C R K Q S S K H A L G Y T L H P P S Q A V E G Q H K D M V R I P V G S R E T F Y R I S K T D G V C E W K F F S S M P R G S A R I T V S K D Q S S C T T A R V R S K S F L Q V C C C V G P S T P S L D K N H Q V P T I K V H T I S L S E N G E E V C-term P V N I S K A I L L G V I L G G L I L F G V L G N I L V I L S V A C H S V T H Y Y I V N L A V A D L L L T S T V L P F S A I F E V L G G R V F C N I W A A V D V L C C T A S I M G L C I I S I D R Y I G V S Y T Q R R G L M A L L C V W A L S L V I S I G P L F G W E P G Y V L F S A L G S F Y L P L A I I L V M Y C R V Y V V A K R E S R G L K S G L L L K F S R E K K A A K T L G I V V G C F V L C W L P F F L V M P I G S F F S E T V F K I V F W L G Y L N S C I N P I I Y P C S S Q E F Q N F K K A V L R
Helix box plot — Download: PNG | SVG I N G L V G F L I L G G L I V G L L I A 1 V N L A V A D L L L T T S V L P F S A I F 2 I C L G M I S A T C C L V D V A A W I N 3 G L M A L L C V W A L S L V I S I G P L 4 Y M V L I I A L P L Y F S G L A S F L V Y 5 G I V V G C F V L C W L P F F L V M P I 6 I P N I C S N L Y G L W F V I K F V T 7

GPCRdb(A)
GPCRdb(A)
α1A-adrenoceptor
TM2
2x63 2.64x63 F86
TM3
3x28 3.28x28 W102
3x32 3.32x32 D106
3x33 3.33x33 V107
3x36 3.36x36 C110
ECL2
45x50 45.50x50 C176
TM6
6x51 6.51x51 F288
6x52 6.52x52 F289
6x55 6.55x55 M292
TM7
7x38 7.39x38 F312
7x42 7.43x42 Y316