Structure information

A2A receptor

PROTEIN CLASS

Class A (Rhodopsin)

PDB CODE

8A2P

SPECIES

Homo sapiens

RESOLUTION

3.500

PREFERRED CHAIN

A

REFERENCE

10.1107/S1600576723006428

PUBLICATION DATE

Aug. 30, 2023

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
CHEMBL1671936 I66 2.64x63 TM2 hydrophobic
CHEMBL1671936 L167 45.51x51 ECL2 hydrophobic
CHEMBL1671936 F168 45.52x52 ECL2 Van der Waals
CHEMBL1671936 F168 45.52x52 ECL2 aromatic (face-to-face)
CHEMBL1671936 F168 45.52x52 ECL2 polar (hydrogen bond with backbone)
CHEMBL1671936 M177 5.38x40 TM5 hydrophobic
CHEMBL1671936 M177 5.38x40 TM5 Van der Waals
CHEMBL1671936 W246 6.48x48 TM6 Van der Waals
CHEMBL1671936 L249 6.51x51 TM6 hydrophobic
CHEMBL1671936 L249 6.51x51 TM6 Van der Waals
CHEMBL1671936 H250 6.52x52 TM6 aromatic (face-to-edge)
CHEMBL1671936 H250 6.52x52 TM6 Van der Waals
CHEMBL1671936 N253 6.55x55 TM6 polar (hydrogen bond)
CHEMBL1671936 N253 6.55x55 TM6 Van der Waals
CHEMBL1671936 I274 7.39x38 TM7 hydrophobic
CHEMBL1671936 I274 7.39x38 TM7 Van der Waals

Ligands

CHEMBL1671936

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Residue Diagrams

V N G L I A L V A I A L E V T I Y V S S 1 V S L A A A D I A V G L V A I P F A I T I 2 A L L S F I S S Q T L V L V F C A I F L 3 A K G I I A I C W V L S F A I G L T P M 4 Y V G L M L L L P V L V C A F F N F Y V M Y 5 A I I V G L F A L C W L P L H I I N C F 6 F P N V V S N T H S L V I A L Y M L W 7
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ICL1 S N L Q ICL1ECL1 F C A ECL1ICL2 P L R Y N G L V ICL2ECL2 W N N C G Q P K E G K N H S Q G C G E G Q V A C L F E D V V ECL2ICL3 Q P L P G ICL3ECL3 P D C S H A ECL3C-term K A A G T S A R V L A A H G S D G E Q V S L R L N G H P P G V W A N G S A P H P E R R P N G Y A L G L V S G G S A Q E S Q G N T G L P D V E L L S H E L K G V C P E P P G L D D P L A Q D G A G V S C-term M P I M G S S V Y I T V E L A I A V L A I L G N V L V C W A V W L N N V T N Y F V V S L A A A D I A V G V L A I P F A I T I S T G A C H G C L F I A C F V L V L T Q S S I F S L L A I A I D R Y I A I R I T G T R A K G I I A I C W V L S F A I G L T P M L G P M N Y M V Y F N F F A C V L V P L L L M L G V Y L R I F L A A R R Q L K Q M E S E R A R S T L Q K E V H A A K S L A I I V G L F A L C W L P L H I I N C F T F F C P L W L M Y L A I V L S H T N S V V N P F I Y A Y R I R E F R K H V L P F F R Q T I I R S R Q Q E
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Residue Table


GPCRdb(A)
GPCRdb(A)
A2A receptor
TM2
2x63 2.64x63 I66
ECL2
45x51 45.51x51 L167
45x52 45.52x52 F168
TM5
5x40 5.38x40 M177
TM6
6x48 6.48x48 W246
6x51 6.51x51 L249
6x52 6.52x52 H250
6x55 6.55x55 N253
TM7
7x38 7.39x38 I274