Ligand
Function
Agonist
Reference
| Ligand | Amino Acid | Generic Number | Segment | Interaction Type |
|---|---|---|---|---|
| all-trans-retinal | E514 | 3.28x28 | TM3 | Van der Waals |
| all-trans-retinal | A518 | 3.32x32 | TM3 | hydrophobic |
| all-trans-retinal | T519 | 3.33x33 | TM3 | hydrophobic |
| all-trans-retinal | G522 | 3.36x36 | TM3 | Van der Waals |
| all-trans-retinal | E523 | 3.37x37 | TM3 | hydrophobic |
| all-trans-retinal | L526 | 3.40x40 | TM3 | Van der Waals |
| all-trans-retinal | E582 | ECL2 | Van der Waals | |
| all-trans-retinal | S587 | ECL2 | Van der Waals | |
| all-trans-retinal | C588 | 45.50x50 | ECL2 | Van der Waals |
| all-trans-retinal | I590 | 45.52x52 | ECL2 | Van der Waals |
| all-trans-retinal | Y592 | ECL2 | Van der Waals | |
| all-trans-retinal | M608 | 5.42x43 | TM5 | hydrophobic |
| all-trans-retinal | F609 | 5.43x44 | TM5 | Van der Waals |
| all-trans-retinal | H612 | 5.46x461 | TM5 | Van der Waals |
| all-trans-retinal | F613 | 5.47x47 | TM5 | hydrophobic |
| all-trans-retinal | F662 | 6.44x44 | TM6 | hydrophobic |
| all-trans-retinal | W666 | 6.48x48 | TM6 | hydrophobic |
| all-trans-retinal | Y669 | 6.51x51 | TM6 | hydrophobic |
| all-trans-retinal | A670 | 6.52x52 | TM6 | hydrophobic |
| all-trans-retinal | A693 | 7.39x38 | TM7 | hydrophobic |
| all-trans-retinal | K697 | 7.43x42 | TM7 | covalent bond |
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|
GPCRdb(A)
|
GPCRdb(A)
|
Rhodopsin
|
|---|---|---|
| TM3 | ||
| 3x28 | 3.28x28 | E113 |
| 3x32 | 3.32x32 | A117 |
| 3x33 | 3.33x33 | T118 |
| 3x36 | 3.36x36 | G121 |
| 3x37 | 3.37x37 | E122 |
| 3x40 | 3.40x40 | L125 |
| ECL2 | ||
| 45x50 | 45.50x50 | C187 |
| 45x52 | 45.52x52 | I189 |
| TM5 | ||
| 5x43 | 5.42x43 | M207 |
| 5x44 | 5.43x44 | F208 |
| 5x461 | 5.46x461 | H211 |
| 5x47 | 5.47x47 | F212 |
| TM6 | ||
| 6x44 | 6.44x44 | F261 |
| 6x48 | 6.48x48 | W265 |
| 6x51 | 6.51x51 | Y268 |
| 6x52 | 6.52x52 | A269 |
| TM7 | ||
| 7x38 | 7.39x38 | A292 |
| 7x42 | 7.43x42 | K296 |