PDB
8DPG
Resolution
3.6 Å
Released
Aug. 24, 2022
Receptor
5-HT2C
Class
A
Species
Homo sapiens
Ligand
Function
psilocin
Agonist (partial)
Reference
10.1016/J.CELREP.2022.111211

NGL is a WebGL based 3D viewer powered by MMTF.

Download PDB file
Download list in excel
Ligand Amino Acid Generic Number Segment Interaction Type
psilocin D134 3.32x32 TM3 polar (charge-charge)
psilocin D134 3.32x32 TM3 polar (hydrogen bond)
psilocin V135 3.33x33 TM3 hydrophobic
psilocin S138 3.36x36 TM3 Van der Waals
psilocin F214 5.38x39 TM5 hydrophobic
psilocin V215 5.39x40 TM5 Van der Waals
psilocin G218 5.42x43 TM5 Van der Waals
psilocin S219 5.43x44 TM5 Van der Waals
psilocin A222 5.46x461 TM5 Van der Waals
psilocin W324 6.48x48 TM6 Van der Waals
psilocin F327 6.51x51 TM6 Van der Waals
psilocin F328 6.52x52 TM6 aromatic (edge-to-face)
psilocin V354 7.39x38 TM7 Van der Waals
psilocin Y358 7.43x42 TM7 Van der Waals

NGL is a WebGL based 3D viewer powered by MMTF.

Download PDB file

Snake plot — Download: PNG | SVG
ICL1 K K L H ICL1ECL1 Y V W P L ECL1ICL2 P I E H S R F N ICL2ECL2 E E K V F V N N T T C V L N ECL2ICL3 G H T E E P P G L S L D F L K C C K R N T A E E E N S A N P N Q D Q N A R R R K K K E R R P R G T ICL3ECL3 E K S C ECL3N-term M V N L R N A V H S F L V H L I G L L V W Q S D I S V S P V A A I V T D I F N T S D G G R F K F P D G V Q N-termC-term N Y K V E K K P P V R Q I P R V A A T A L S G R E L N V N I Y R H T N E P V I E K A S D N E P G I E M Q V E N L E L P V N P S S V V S E R I S S V C-term N W P A L S I V I I I I M T I G G N I L V I M A V S M E N A T N Y F L M S L A I A D M L V G L L V M P L S L L A I L Y D P R Y L C P V W I S L D V L F S T A S I M H L C A I S L D R Y V A I R N S R T K A I M K I A I V W A I S I G V S V P I P V I G L R D D P N F V L I G S F V A F F I P L T I M V I T Y C L T I Y V L R R Q A L M L L H M Q A I N N E R K A S K V L G I V F F V F L I M W C P F F I T N I L S V L C N Q K L M E K L L N V F V W I G Y V C S G I N P L V Y T L F N K I F S N Y R R A Y L R C
Helix box plot — Download: PNG | SVG I N G G I T M I I I I V I S L A P W N 1 M S L A I A D M L V G L L V M P L S L L A 2 A C L H M I S A T S F L V D L S I W V P 3 A I M K I A I V W A I S I G V S V P I 4 Y T I V M I T L P I F F A V F S G I L V F 5 G I V F F V F L I M W C P F F I T N I L 6 L P N I G S C V Y G I W V F V N L L K 7

GPCRdb(A)
GPCRdb(A)
5-HT2C receptor
TM3
3x32 3.32x32 D134
3x33 3.33x33 V135
3x36 3.36x36 S138
TM5
5x39 5.38x39 F214
5x40 5.39x40 V215
5x43 5.42x43 G218
5x44 5.43x44 S219
5x461 5.46x461 A222
TM6
6x48 6.48x48 W324
6x51 6.51x51 F327
6x52 6.52x52 F328
TM7
7x38 7.39x38 V354
7x42 7.43x42 Y358