Structure information

MRGPRX1

PROTEIN CLASS

Class A (Rhodopsin)

PDB CODE

8DWC

SPECIES

Homo sapiens

RESOLUTION

2.870

PREFERRED CHAIN

R

REFERENCE

10.1038/S41589-022-01173-6

PUBLICATION DATE

Nov. 2, 2022

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
Proenkephalin-A Y99 3.29x29 TM3 Van der Waals
Proenkephalin-A Y99 3.29x29 TM3 polar (hydrogen bond)
Proenkephalin-A P100 3.30x30 TM3 hydrophobic
Proenkephalin-A P100 3.30x30 TM3 Van der Waals
Proenkephalin-A E157 4.60x60 TM4 polar (charge-assisted hydrogen bond)
Proenkephalin-A W158 4.61x61 TM4 Van der Waals
Proenkephalin-A W158 4.61x61 TM4 aromatic (edge-to-face)
Proenkephalin-A C161 4.64x64 TM4 polar (hydrogen bond)
Proenkephalin-A F163 ECL2 hydrophobic
Proenkephalin-A F163 ECL2 Van der Waals
Proenkephalin-A C173 5.36x36 TM5 Van der Waals
Proenkephalin-A F236 6.55x55 TM6 hydrophobic
Proenkephalin-A L240 6.59x59 TM6 polar (hydrogen bond with backbone)
Proenkephalin-A L240 6.59x59 TM6 Van der Waals
Proenkephalin-A W241 6.60x60 TM6 Van der Waals
Proenkephalin-A W241 6.60x60 TM6 aromatic (face-to-edge)
Proenkephalin-A H243 ECL3 Van der Waals
Proenkephalin-A F250 7.31x30 TM7 hydrophobic
Proenkephalin-A F250 7.31x30 TM7 Van der Waals
Proenkephalin-A H254 7.35x34 TM7 Van der Waals

Ligands

Proenkephalin-A

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Residue Diagrams

A N G T L G V L S V I C T L V T L S L T 1 L N L A A A D F L F L S G R L I Y S L L 2 A S L F S L G A F Y S F M M V P Y L I K 3 S A V V C V L L W A L S L L R S I L E W 4 S S G C L V V C L F I L W A V T I F D S 5 L L T V L V F L L C G L P F G I Q F F L 6 I P N A S S N L A S L F I S V L H V H 7
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ICL1 R R ICL1ECL1 S I P H T ECL1ICL2 P I W Y R C H R ICL2ECL2 G F L F S G A ECL2ICL3 G S R K I ICL3ECL3 V D R E V ECL3N-term M D P T I S T L D T E L T P I N G T E E T L C Y K N-termC-term Q R Q N R Q N L K L V L Q R A L Q D A S E V D E G G G Q L P E E I L E L S G S R L E Q C-term Q T L S L T V L T C I V S L V G L T G N A V V L W L L G C R M N A F S I Y I L N L A A A D F L F L S G R L I Y S L L S F I I S K I L Y P V M M F S Y F A G L S F L S A V S T E R C L S V L W P T H L S A V V C V L L W A L S L L R S I L E W M L C D S A W C Q T S D F I T V A W L I F L C V V L C G S S L V L L I R I L C P L T R L Y V T I L L T V L V F L L C G L P F G I Q F F L F L W I H L F C H V H L V S I F L S A L N S S A N P I I Y F F V G S F R
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Residue Table


GPCRdb(A)
GPCRdb(A)
MRGPRX1
TM3
3x29 3.29x29 Y99
3x30 3.30x30 P100
TM4
4x60 4.60x60 E157
4x61 4.61x61 W158
4x64 4.64x64 C161
TM5
5x36 5.36x36 C173
TM6
6x55 6.55x55 F236
6x59 6.59x59 L240
6x60 6.60x60 W241
TM7
7x30 7.31x30 F250
7x34 7.35x34 H254