PDB
8DZR
Resolution
2.6 Å
Released
May 3, 2023
Receptor
κ
Class
A
Species
Homo sapiens
Ligand
Function
CHEMBL277863
Agonist
Reference
10.1038/S41586-023-06030-7

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Ligand Amino Acid Generic Number Segment Interaction Type
CHEMBL277863 V108 2.53x53 TM2 Van der Waals
CHEMBL277863 T111 2.56x56 TM2 Van der Waals
CHEMBL277863 F114 2.59x59 TM2 Van der Waals
CHEMBL277863 Q115 2.60x60 TM2 hydrophobic
CHEMBL277863 V134 3.28x28 TM3 hydrophobic
CHEMBL277863 L135 3.29x29 TM3 Van der Waals
CHEMBL277863 D138 3.32x32 TM3 polar (charge-charge)
CHEMBL277863 Y139 3.33x33 TM3 hydrophobic
CHEMBL277863 M142 3.36x36 TM3 Van der Waals
CHEMBL277863 C210 45.50x50 ECL2 Van der Waals
CHEMBL277863 V230 5.42x43 TM5 Van der Waals
CHEMBL277863 W287 6.48x48 TM6 hydrophobic
CHEMBL277863 I290 6.51x51 TM6 Van der Waals
CHEMBL277863 H291 6.52x52 TM6 Van der Waals
CHEMBL277863 I294 6.55x55 TM6 Van der Waals
CHEMBL277863 I316 7.39x38 TM7 Van der Waals
CHEMBL277863 Y320 7.43x42 TM7 aromatic (pi-cation)

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Snake plot — Download: PNG | SVG
ICL1 T K M K ICL1ECL1 S W P F ECL1ICL2 P V K A L D F R ICL2ECL2 G T K V R E D V D V I E C S L Q F P D D ECL2ICL3 R L L S G ICL3ECL3 S T S H ECL3N-term M D S P I Q I F R G E P G P T C A P S A C L P P N S S A W F P G W A E P D S N G S A G S E D A Q L E P A H I S P N-termC-term P L K M R M E R Q S T S R V R N T V Q D P A Y L R D I D G M N K P V C-term A I P V I I T A V Y S V V F V V G L V G N S L V M F V I I R Y T A T N I Y I F N L A L A D A L V T T T M P F Q S T V Y L M N G D V L C K I V I S I D Y Y N M F T S I F T L T M M S V D R Y I A V C H T P L K A K I I N I C I W L L S S S V G I S A I V L G D Y S W W D L F M K I C V F I F A F V I P V L I I I V C Y T L M I L R L K S V S R E K D R N L R R I T R L V L V V V A V F V V C W T P I H I F I L V E A L G S T A A L S S Y Y F C I A L G Y T N S S L N P I L Y A F L D E N F R D F K R C F C F
Helix box plot — Download: PNG | SVG S N G V L G V V F V V S Y V A T I I V P 1 F N L A L A D A L V T T T M P F Q S T V 2 M T L T F I S T F M N Y Y D I S I V I K 3 A K I I N I C I W L L S S S V G I S A I 4 Y C V I I I L V P I V F A F I F V C I K M 5 L V V V A V F V V C W T P I H I F I L V 6 I P N L S S N T Y G L A I C F Y Y S S 7

GPCRdb(A)
GPCRdb(A)
κ receptor
TM2
2x53 2.53x53 V108
2x56 2.56x56 T111
2x59 2.59x59 F114
2x60 2.60x60 Q115
TM3
3x28 3.28x28 V134
3x29 3.29x29 I135
3x32 3.32x32 D138
3x33 3.33x33 Y139
3x36 3.36x36 M142
ECL2
45x50 45.50x50 C210
TM5
5x43 5.42x43 V230
TM6
6x48 6.48x48 W287
6x51 6.51x51 I290
6x52 6.52x52 H291
6x55 6.55x55 I294
TM7
7x38 7.39x38 I316
7x42 7.43x42 Y320