PDB
8E0G
Resolution
2.1 Å
Released
Oct. 18, 2023
Receptor
μ
Class
A
Species
Mus musculus
Ligand
BU72, modelled as covalent adduct A1A7R (modified HIS) at A/54
Function
Agonist
Reference
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Ligand Amino Acid Generic Number Segment Interaction Type
BU72, modelled as covalent adduct A1A7R (modified HIS) at A/54 S53 N-term polar (hydrogen bond with backbone)
BU72, modelled as covalent adduct A1A7R (modified HIS) at A/54 S53 N-term Van der Waals
BU72, modelled as covalent adduct A1A7R (modified HIS) at A/54 S53 N-term polar (hydrogen bond)
BU72, modelled as covalent adduct A1A7R (modified HIS) at A/54 S55 N-term Van der Waals
BU72, modelled as covalent adduct A1A7R (modified HIS) at A/54 S55 N-term polar (hydrogen bond with backbone)
BU72, modelled as covalent adduct A1A7R (modified HIS) at A/54 L56 N-term polar (hydrogen bond with backbone)
BU72, modelled as covalent adduct A1A7R (modified HIS) at A/54 L56 N-term Van der Waals
BU72, modelled as covalent adduct A1A7R (modified HIS) at A/54 Q124 2.60x60 TM2 Van der Waals
BU72, modelled as covalent adduct A1A7R (modified HIS) at A/54 I144 3.29x29 TM3 hydrophobic
BU72, modelled as covalent adduct A1A7R (modified HIS) at A/54 I144 3.29x29 TM3 Van der Waals
BU72, modelled as covalent adduct A1A7R (modified HIS) at A/54 D147 3.32x32 TM3 polar (charge-assisted hydrogen bond)
BU72, modelled as covalent adduct A1A7R (modified HIS) at A/54 Y148 3.33x33 TM3 polar (hydrogen bond)
BU72, modelled as covalent adduct A1A7R (modified HIS) at A/54 Y148 3.33x33 TM3 polar (hydrogen bond)
BU72, modelled as covalent adduct A1A7R (modified HIS) at A/54 M151 3.36x36 TM3 Van der Waals
BU72, modelled as covalent adduct A1A7R (modified HIS) at A/54 M151 3.36x36 TM3 hydrophobic
BU72, modelled as covalent adduct A1A7R (modified HIS) at A/54 D216 ECL2 polar (charge-assisted hydrogen bond)
BU72, modelled as covalent adduct A1A7R (modified HIS) at A/54 C217 45.50x50 ECL2 Van der Waals
BU72, modelled as covalent adduct A1A7R (modified HIS) at A/54 T218 45.51x51 ECL2 Van der Waals
BU72, modelled as covalent adduct A1A7R (modified HIS) at A/54 V236 5.42x43 TM5 Van der Waals
BU72, modelled as covalent adduct A1A7R (modified HIS) at A/54 V236 5.42x43 TM5 hydrophobic
BU72, modelled as covalent adduct A1A7R (modified HIS) at A/54 W293 6.48x48 TM6 hydrophobic
BU72, modelled as covalent adduct A1A7R (modified HIS) at A/54 I296 6.51x51 TM6 Van der Waals
BU72, modelled as covalent adduct A1A7R (modified HIS) at A/54 I296 6.51x51 TM6 hydrophobic
BU72, modelled as covalent adduct A1A7R (modified HIS) at A/54 H297 6.52x52 TM6 Van der Waals
BU72, modelled as covalent adduct A1A7R (modified HIS) at A/54 V300 6.55x55 TM6 Van der Waals
BU72, modelled as covalent adduct A1A7R (modified HIS) at A/54 V300 6.55x55 TM6 hydrophobic
BU72, modelled as covalent adduct A1A7R (modified HIS) at A/54 W318 7.35x34 TM7 hydrophobic
BU72, modelled as covalent adduct A1A7R (modified HIS) at A/54 W318 7.35x34 TM7 Van der Waals
BU72, modelled as covalent adduct A1A7R (modified HIS) at A/54 I322 7.39x38 TM7 hydrophobic
BU72, modelled as covalent adduct A1A7R (modified HIS) at A/54 I322 7.39x38 TM7 Van der Waals
BU72, modelled as covalent adduct A1A7R (modified HIS) at A/54 Y326 7.43x42 TM7 polar (hydrogen bond)

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Snake plot — Download: PNG | SVG
ICL1 T K M K ICL1ECL1 T W P F ECL1ICL2 P V K A L D F R ICL2ECL2 T T K Y R Q G S I D C T L T F S H ECL2ICL3 R M L S G ICL3ECL3 T I P E ECL3N-term M D S S A G P G N I S D C S D P L A P A S C S P A P G S W L N L S H V D G N Q S D P C G P N R T G L G G S H S L C P Q T G S P S N-termC-term P T S S T I E Q Q N S A R I R Q N T R E H P S T A N T V D R T N H Q L E N L E A E T A P L P C-term M V T A I T I M A L Y S I V C V V G L F G N F L V M Y V I V R Y T A T N I Y I F N L A L A D A L A T S T L P F Q S V N Y L M G G N I L C K I V I S I D Y Y N M F T S I F T L C T M S V D R Y I A V C H T P R N A K I V N V C N W I L S S A I G L P V M F M A P T W Y W E N L L K I C V F I F A F I M P V L I I T V C Y G L M I L R L K S V S K E K D R N L R R I T R M V L V V V A V F I V C W T P I H I Y V I I K A L I T T F Q T V S W H F C I A L G Y T N S C L N P V L Y A F L D E N F R E F K R C F C I
Helix box plot — Download: PNG | SVG F N G F L G V V C V I S Y L A M I T I A 1 F N L A L A D A L A T S T L P F Q S V N 2 T C L T F I S T F M N Y Y D I S I V I K 3 A K I V N V C N W I L S S A I G L P V M 4 Y C V T I I L V P M I F A F I F V C I K L 5 L V V V A V F I V C W T P I H I Y V I I 6 V P N L C S N T Y G L A I C F H W S V 7

GPCRdb(A)
GPCRdb(A)
μ receptor
TM2
2x60 2.60x60 Q124
TM3
3x29 3.29x29 I144
3x32 3.32x32 D147
3x33 3.33x33 Y148
3x36 3.36x36 M151
ECL2
45x50 45.50x50 C217
45x51 45.51x51 T218
TM5
5x43 5.42x43 V236
TM6
6x48 6.48x48 W293
6x51 6.51x51 I296
6x52 6.52x52 H297
6x55 6.55x55 V300
TM7
7x34 7.35x34 W318
7x38 7.39x38 I322
7x42 7.43x42 Y326