Structure information

μ receptor

PROTEIN CLASS

Class A (Rhodopsin)

PDB CODE

8EF5

SPECIES

Homo sapiens

RESOLUTION

3.300

PREFERRED CHAIN

R

REFERENCE

10.1016/J.CELL.2022.09.041

PUBLICATION DATE

Nov. 9, 2022

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
fentanyl W135 23.50x50 ECL1 aromatic (face-to-edge)
fentanyl I146 3.29x29 TM3 hydrophobic
fentanyl D149 3.32x32 TM3 polar (charge-assisted hydrogen bond)
fentanyl Y150 3.33x33 TM3 hydrophobic
fentanyl Y150 3.33x33 TM3 Van der Waals
fentanyl M153 3.36x36 TM3 hydrophobic
fentanyl M153 3.36x36 TM3 Van der Waals
fentanyl C219 45.50x50 ECL2 Van der Waals
fentanyl W295 6.48x48 TM6 Van der Waals
fentanyl W295 6.48x48 TM6 hydrophobic
fentanyl I298 6.51x51 TM6 hydrophobic
fentanyl I298 6.51x51 TM6 Van der Waals
fentanyl I324 7.39x38 TM7 hydrophobic
fentanyl I324 7.39x38 TM7 Van der Waals
fentanyl G327 7.42x41 TM7 Van der Waals
fentanyl Y328 7.43x42 TM7 hydrophobic
fentanyl Y328 7.43x42 TM7 Van der Waals

Ligands

fentanyl

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Residue Diagrams

F N G F L G V V C V I S Y L A M I T I A 1 F N L A L A D A L A T S T L P F Q S V N 2 T C L T F I S T F M N Y Y D I S I V I K 3 A K I I N V C N W I L S S A I G L P V M 4 Y C V T I I L V P M I F A F I F V C I K L 5 L V V V A V F I V C W T P I H I Y V I I 6 V P N L C S N T Y G L A I C F H W S V 7
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ICL1 T K M K ICL1ECL1 T W P F ECL1ICL2 P V K A L D F R ICL2ECL2 T T K Y R Q G S I D C T L T F S H ECL2ICL3 R M L S G ICL3ECL3 T I P E ECL3N-term M D S S A A P T N A S N C T D A L A Y S S C S P A P S P G S W V N L S H L D G N L S D P C G P N R T D L G G R D S L C P P T G S P S N-termC-term P T S S N I E Q Q N S T R I R Q N T R D H P S T A N T V D R T N H Q L E N L E A E T A P L P C-term M I T A I T I M A L Y S I V C V V G L F G N F L V M Y V I V R Y T A T N I Y I F N L A L A D A L A T S T L P F Q S V N Y L M G G T I L C K I V I S I D Y Y N M F T S I F T L C T M S V D R Y I A V C H T P R N A K I I N V C N W I L S S A I G L P V M F M A P T W Y W E N L L K I C V F I F A F I M P V L I I T V C Y G L M I L R L K S V S K E K D R N L R R I T R M V L V V V A V F I V C W T P I H I Y V I I K A L V T T F Q T V S W H F C I A L G Y T N S C L N P V L Y A F L D E N F R E F K R C F C I
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Residue Table


GPCRdb(A)
GPCRdb(A)
μ receptor
ECL1
23x50 23.50x50 W135
TM3
3x29 3.29x29 I146
3x32 3.32x32 D149
3x33 3.33x33 Y150
3x36 3.36x36 M153
ECL2
45x50 45.50x50 C219
TM6
6x48 6.48x48 W295
6x51 6.51x51 I298
TM7
7x38 7.39x38 I324
7x41 7.42x41 G327
7x42 7.43x42 Y328