PDB
8EFL
Resolution
3.2 Å
Released
Nov. 9, 2022
Receptor
μ
Class
A
Species
Homo sapiens
Ligand
Function
CHEMBL4452384
Agonist (partial)
Reference
10.1016/J.CELL.2022.09.041

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Ligand Amino Acid Generic Number Segment Interaction Type
CHEMBL4452384 T122 2.56x56 TM2 Van der Waals
CHEMBL4452384 Q126 2.60x60 TM2 hydrophobic
CHEMBL4452384 N129 2.63x63 TM2 halogen contact
CHEMBL4452384 W135 23.50x50 ECL1 hydrophobic
CHEMBL4452384 V145 3.28x28 TM3 hydrophobic
CHEMBL4452384 D149 3.32x32 TM3 polar (hydrogen bond)
CHEMBL4452384 D149 3.32x32 TM3 polar (charge-charge)
CHEMBL4452384 Y150 3.33x33 TM3 hydrophobic
CHEMBL4452384 Y150 3.33x33 TM3 aromatic (pi-cation)
CHEMBL4452384 M153 3.36x36 TM3 hydrophobic
CHEMBL4452384 C219 45.50x50 ECL2 hydrophobic
CHEMBL4452384 V238 5.42x43 TM5 hydrophobic
CHEMBL4452384 I298 6.51x51 TM6 hydrophobic
CHEMBL4452384 H299 6.52x52 TM6 Van der Waals
CHEMBL4452384 V302 6.55x55 TM6 hydrophobic
CHEMBL4452384 Y328 7.43x42 TM7 Van der Waals

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Snake plot — Download: PNG | SVG
ICL1 T K M K ICL1ECL1 T W P F ECL1ICL2 P V K A L D F R ICL2ECL2 T T K Y R Q G S I D C T L T F S H ECL2ICL3 R M L S G ICL3ECL3 T I P E ECL3N-term M D S S A A P T N A S N C T D A L A Y S S C S P A P S P G S W V N L S H L D G N L S D P C G P N R T D L G G R D S L C P P T G S P S N-termC-term P T S S N I E Q Q N S T R I R Q N T R D H P S T A N T V D R T N H Q L E N L E A E T A P L P C-term M I T A I T I M A L Y S I V C V V G L F G N F L V M Y V I V R Y T A T N I Y I F N L A L A D A L A T S T L P F Q S V N Y L M G G T I L C K I V I S I D Y Y N M F T S I F T L C T M S V D R Y I A V C H T P R N A K I I N V C N W I L S S A I G L P V M F M A P T W Y W E N L L K I C V F I F A F I M P V L I I T V C Y G L M I L R L K S V S K E K D R N L R R I T R M V L V V V A V F I V C W T P I H I Y V I I K A L V T T F Q T V S W H F C I A L G Y T N S C L N P V L Y A F L D E N F R E F K R C F C I
Helix box plot — Download: PNG | SVG F N G F L G V V C V I S Y L A M I T I A 1 F N L A L A D A L A T S T L P F Q S V N 2 T C L T F I S T F M N Y Y D I S I V I K 3 A K I I N V C N W I L S S A I G L P V M 4 Y C V T I I L V P M I F A F I F V C I K L 5 L V V V A V F I V C W T P I H I Y V I I 6 V P N L C S N T Y G L A I C F H W S V 7

GPCRdb(A)
GPCRdb(A)
μ receptor
TM2
2x56 2.56x56 T122
2x60 2.60x60 Q126
2x63 2.63x63 N129
ECL1
23x50 23.50x50 W135
TM3
3x28 3.28x28 V145
3x32 3.32x32 D149
3x33 3.33x33 Y150
3x36 3.36x36 M153
ECL2
45x50 45.50x50 C219
TM5
5x43 5.42x43 V238
TM6
6x51 6.51x51 I298
6x52 6.52x52 H299
6x55 6.55x55 V302
TM7
7x42 7.43x42 Y328