PDB
8EFO
Resolution
2.8 Å
Released
Nov. 9, 2022
Receptor
μ
Class
A
Species
Homo sapiens
Ligand
Function
PZM21
Agonist
Reference
10.1016/J.CELL.2022.09.041

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Ligand Amino Acid Generic Number Segment Interaction Type
PZM21 T122 2.56x56 TM2 hydrophobic
PZM21 Q126 2.60x60 TM2 hydrophobic
PZM21 N129 2.63x63 TM2 Van der Waals
PZM21 W135 23.50x50 ECL1 hydrophobic
PZM21 V145 3.28x28 TM3 hydrophobic
PZM21 I146 3.29x29 TM3 hydrophobic
PZM21 D149 3.32x32 TM3 polar (charge-charge)
PZM21 D149 3.32x32 TM3 hydrophobic
PZM21 D149 3.32x32 TM3 polar (hydrogen bond)
PZM21 Y150 3.33x33 TM3 aromatic (pi-cation)
PZM21 Y150 3.33x33 TM3 hydrophobic
PZM21 M153 3.36x36 TM3 hydrophobic
PZM21 K235 5.39x40 TM5 Van der Waals
PZM21 V238 5.42x43 TM5 hydrophobic
PZM21 I298 6.51x51 TM6 hydrophobic
PZM21 V302 6.55x55 TM6 hydrophobic
PZM21 W320 7.35x34 TM7 Van der Waals
PZM21 I324 7.39x38 TM7 Van der Waals
PZM21 Y328 7.43x42 TM7 Van der Waals

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ICL1 T K M K ICL1ECL1 T W P F ECL1ICL2 P V K A L D F R ICL2ECL2 T T K Y R Q G S I D C T L T F S H ECL2ICL3 R M L S G ICL3ECL3 T I P E ECL3N-term M D S S A A P T N A S N C T D A L A Y S S C S P A P S P G S W V N L S H L D G N L S D P C G P N R T D L G G R D S L C P P T G S P S N-termC-term P T S S N I E Q Q N S T R I R Q N T R D H P S T A N T V D R T N H Q L E N L E A E T A P L P C-term M I T A I T I M A L Y S I V C V V G L F G N F L V M Y V I V R Y T A T N I Y I F N L A L A D A L A T S T L P F Q S V N Y L M G G T I L C K I V I S I D Y Y N M F T S I F T L C T M S V D R Y I A V C H T P R N A K I I N V C N W I L S S A I G L P V M F M A P T W Y W E N L L K I C V F I F A F I M P V L I I T V C Y G L M I L R L K S V S K E K D R N L R R I T R M V L V V V A V F I V C W T P I H I Y V I I K A L V T T F Q T V S W H F C I A L G Y T N S C L N P V L Y A F L D E N F R E F K R C F C I
Helix box plot — Download: PNG | SVG F N G F L G V V C V I S Y L A M I T I A 1 F N L A L A D A L A T S T L P F Q S V N 2 T C L T F I S T F M N Y Y D I S I V I K 3 A K I I N V C N W I L S S A I G L P V M 4 Y C V T I I L V P M I F A F I F V C I K L 5 L V V V A V F I V C W T P I H I Y V I I 6 V P N L C S N T Y G L A I C F H W S V 7

GPCRdb(A)
GPCRdb(A)
μ receptor
TM2
2x56 2.56x56 T122
2x60 2.60x60 Q126
2x63 2.63x63 N129
ECL1
23x50 23.50x50 W135
TM3
3x28 3.28x28 V145
3x29 3.29x29 I146
3x32 3.32x32 D149
3x33 3.33x33 Y150
3x36 3.36x36 M153
TM5
5x40 5.39x40 K235
5x43 5.42x43 V238
TM6
6x51 6.51x51 I298
6x55 6.55x55 V302
TM7
7x34 7.35x34 W320
7x38 7.39x38 I324
7x42 7.43x42 Y328