PDB
8EIT
Resolution
2.8 Å
Released
May 24, 2023
Receptor
FFA1
Class
A
Species
Homo sapiens
Ligand
docosahexaenoic acid
Function
Agonist
Reference
10.1073/PNAS.2219569120

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Ligand Amino Acid Generic Number Segment Interaction Type
docosahexaenoic acid V84 3.30x30 TM3 hydrophobic
docosahexaenoic acid F87 3.33x33 TM3 hydrophobic
docosahexaenoic acid Y91 3.37x37 TM3 Van der Waals
docosahexaenoic acid Y91 3.37x37 TM3 polar (hydrogen bond)
docosahexaenoic acid L138 4.57x57 TM4 Van der Waals
docosahexaenoic acid F142 4.61x61 TM4 Van der Waals
docosahexaenoic acid F142 4.61x61 TM4 hydrophobic
docosahexaenoic acid L171 45.51x51 ECL2 Van der Waals
docosahexaenoic acid R183 5.39x40 TM5 polar (charge-assisted hydrogen bond)
docosahexaenoic acid L186 5.42x43 TM5 Van der Waals
docosahexaenoic acid L186 5.42x43 TM5 hydrophobic
docosahexaenoic acid Y240 6.51x51 TM6 polar (hydrogen bond)
docosahexaenoic acid Y240 6.51x51 TM6 Van der Waals
docosahexaenoic acid R258 7.35x34 TM7 Van der Waals

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Snake plot — Download: PNG | SVG
ICL1 L ICL1ECL1 G A W P L ECL1ICL2 P L G Y Q A F R ICL2ECL2 P G G W L D H S N T S L G I N T P V N G S P V C L E A W ECL2ICL3 S G L T H ICL3ECL3 P N L G ECL3N-term M D L N-termC-term G G K S Q K C-term P P Q L S F G L Y V A A F A L G F P L N V L A I R G A T A H A R L R T P S L V Y A L N L G C S D L L L T V S L P L K A V E A L A S P A S L C P V F A V A H F F P L Y A G G G F L A A L S A G R Y L G A A F R P C Y S W G V C A A I W A L V L C H L G L V F G L E A D P A S A G P A R F S L S L L L F F L P L A I T A F C Y V G C L R A L A R R R K L R A A W V A G G A L L T L L L C V G P Y N A S N V A S F L Y G S W R K L G L I T G A W S V V L N P L V T G Y L G R G T V C Q P G L K A A R T
Helix box plot — Download: PNG | SVG V N L P F G L A F A A V Y L G F S L Q P 1 L N L G C S D L L L T V S L P L K A V E 2 A A L F G G G A Y L P F F H A V A F V P 3 S W G V C A A I W A L V L C H L G L V F 4 Y C F A T I A L P L F F L L L S L S F R A 5 A G G A L L T L L L C V G P Y N A S N V A 6 L P N L V V S W A G T I L G L K R W S 7

GPCRdb(A)
GPCRdb(A)
FFA1 receptor
TM3
3x30 3.30x30 V84
3x33 3.33x33 F87
3x37 3.37x37 Y91
TM4
4x57 4.57x57 L138
4x61 4.61x61 F142
ECL2
45x51 45.51x51 L171
TM5
5x40 5.39x40 R183
5x43 5.42x43 L186
TM6
6x51 6.51x51 Y240
TM7
7x34 7.35x34 R258