Structure information

CT receptor

PROTEIN CLASS

Class B1 (Secretin)

PDB CODE

8F0K

SPECIES

Homo sapiens

RESOLUTION

1.900

PREFERRED CHAIN

R

REFERENCE

10.1038/S41589-023-01393-4

PUBLICATION DATE

Aug. 2, 2023

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
San385 D77 N-term polar (charge-assisted hydrogen bond)
San385 G78 N-term Van der Waals
San385 W79 N-term Van der Waals
San385 W79 N-term aromatic (face-to-edge)
San385 D97 N-term polar (charge-assisted hydrogen bond)
San385 F99 N-term Van der Waals
San385 F99 N-term hydrophobic
San385 P100 N-term Van der Waals
San385 D101 N-term polar (charge-assisted hydrogen bond)
San385 F102 N-term polar (hydrogen bond with backbone)
San385 F102 N-term Van der Waals
San385 P104 N-term Van der Waals
San385 H121 N-term Van der Waals
San385 E123 N-term polar (charge-assisted hydrogen bond)
San385 N124 N-term polar (hydrogen bond)
San385 N124 N-term Van der Waals
San385 R126 N-term polar (charge-assisted hydrogen bond)
San385 W128 N-term Van der Waals
San385 W128 N-term polar (hydrogen bond)
San385 S129 N-term Van der Waals
San385 S129 N-term polar (hydrogen bond with backbone)
San385 Y131 N-term Van der Waals
San385 Y131 N-term hydrophobic
San385 N135 1.26x26 TM1 polar (hydrogen bond)
San385 N135 1.26x26 TM1 Van der Waals
San385 K141 1.32x32 TM1 Van der Waals
San385 L142 1.33x33 TM1 Van der Waals
San385 L142 1.33x33 TM1 hydrophobic
San385 A145 1.36x36 TM1 hydrophobic
San385 A145 1.36x36 TM1 Van der Waals
San385 Y146 1.37x37 TM1 Van der Waals
San385 Y146 1.37x37 TM1 polar (hydrogen bond)
San385 L148 1.39x39 TM1 Van der Waals
San385 L148 1.39x39 TM1 hydrophobic
San385 Y149 1.40x40 TM1 hydrophobic
San385 Y149 1.40x40 TM1 Van der Waals
San385 V206 ECL1 hydrophobic
San385 V206 ECL1 Van der Waals
San385 P207 ECL1 hydrophobic
San385 P207 ECL1 Van der Waals
San385 G209 ECL1 polar (hydrogen bond with backbone)
San385 G209 ECL1 Van der Waals
San385 R213 ECL1 Van der Waals
San385 H226 3.36x36 TM3 polar (hydrogen bond)
San385 Q227 3.37x37 TM3 Van der Waals
San385 M230 3.40x40 TM3 polar (hydrogen bond)
San385 Y234 3.44x44 TM3 hydrophobic
San385 Y234 3.44x44 TM3 Van der Waals
San385 L291 45.52x52 ECL2 Van der Waals
San385 L291 45.52x52 ECL2 polar (hydrogen bond with backbone)
San385 S292 ECL2 Van der Waals
San385 V293 ECL2 Van der Waals
San385 V293 ECL2 polar (hydrogen bond with backbone)
San385 E294 ECL2 polar (hydrogen bond with backbone)
San385 E294 ECL2 Van der Waals
San385 Y299 5.37x38 TM5 Van der Waals
San385 Y299 5.37x38 TM5 hydrophobic
San385 H302 5.40x40 TM5 polar (hydrogen bond)
San385 F356 6.53x53 TM6 hydrophobic
San385 F356 6.53x53 TM6 Van der Waals
San385 P360 ECL3 polar (hydrogen bond with backbone)
San385 P360 ECL3 Van der Waals
San385 W361 ECL3 polar (hydrogen bond)
San385 R362 ECL3 polar (hydrogen bond with backbone)
San385 R362 ECL3 Van der Waals
San385 Y372 7.38x37 TM7 polar (hydrogen bond)
San385 D373 7.39x38 TM7 polar (charge-assisted hydrogen bond)
San385 H377 7.43x42 TM7 Van der Waals
San385 I380 7.46x45 TM7 Van der Waals

Ligands

San385

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Residue Diagrams

V L T F I S L S H G V I A L Y Y L V Y A 1 K N M F L T Y I L N S M I I I I H L V E 2 C L M W F Y N C A M M Y Q H F F H L I K 3 R L R W Y Y L G L W G F P L V P T T I H A 4 L F F F N V V L A A M V P G H I I Y L 5 M I L V P L L G I Q F V V F P W 6 T A V F F G Q F H I L S H M V Y D Y I 7
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ICL1 R S L G ICL1ECL1 V P N G E L V R R D ECL1ICL2 A V F T E K Q ICL2ECL2 N D N C W L S V E T H L ECL2ICL3 E ICL3ECL3 R P S ECL3N-term M R F T F T S R C L A L F L L L N H P T P I L P A F S N Q T Y P T I E P K P F L Y V V G R K K M M D A Q Y K C Y D R M Q Q L P A Y Q G E G P Y C N R T W D G W L C W D D T P A G V L S Y Q F C P D Y F P D F D P S E K V T K Y C D E K G V W F K H P E N N R T W S N Y N-termC-term P S N R S A R A A A A A A E A G D I P I Y I C H Q E L R N E P A N N Q G E E S A E I I P L N I I E Q E S S A C-term T M C N A F T P E K L K N A Y V L Y Y L A I V G H S L S I F T L V I S L G I F V F F C Q R V T L H K N M F L T Y I L N S M I I I I H L V E V P V S C K I L H F F H Q Y M M A C N Y F W M L C E G I Y L H T L I V V R L R W Y Y L L G W G F P L V P T T I H A I T R A V Y F L Y I I H G P V M A A L V V N F F F L L N I V R V L V T K M R E T H A E S H M Y L K A V K A T M I L V P L L G I Q F V V F P W N K M L G K I Y D Y V M H S L I H F Q G F F V A T I Y C F C N N E V K R F K I R W G V Q T T Q W A Q Q W N Q R R
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Residue Table


GPCRdb(A)
GPCRdb(B)
CT receptor
TM1
1x22 1.26x26 N135
1x28 1.32x32 K141
1x29 1.33x33 L142
1x32 1.36x36 A145
1x33 1.37x37 Y146
1x35 1.39x39 L148
1x36 1.40x40 Y149
TM3
3x32 3.36x36 H226
3x33 3.37x37 Q227
3x36 3.40x40 M230
3x40 3.44x44 Y234
ECL2
45x52 45.52x52 L291
TM5
5x42 5.37x38 Y299
5x44 5.40x40 H302
TM6
6x48 6.53x53 F356
TM7
7x33 7.38x37 Y372
7x34 7.39x38 D373
7x38 7.43x42 H377
7x41 7.46x45 I380