PDB
8F7Q
Resolution
3.2 Å
Released
Dec. 14, 2022
Receptor
μ
Class
A
Species
Homo sapiens
Ligand
Beta-endorphin
Function
Agonist
Reference
10.1016/J.CELL.2022.12.026

NGL is a WebGL based 3D viewer powered by MMTF.

Download PDB file
Download list in excel
Ligand Amino Acid Generic Number Segment Interaction Type
Beta-endorphin A70 1.32x32 TM1 hydrophobic
Beta-endorphin I71 1.33x33 TM1 hydrophobic
Beta-endorphin N129 2.63x63 TM2 polar (hydrogen bond)
Beta-endorphin L131 2.65x65 TM2 Van der Waals
Beta-endorphin L131 2.65x65 TM2 polar (hydrogen bond with backbone)
Beta-endorphin G133 2.67x67 TM2 Van der Waals
Beta-endorphin V145 3.28x28 TM3 Van der Waals
Beta-endorphin I146 3.29x29 TM3 Van der Waals
Beta-endorphin I146 3.29x29 TM3 hydrophobic
Beta-endorphin D149 3.32x32 TM3 polar (charge-assisted hydrogen bond)
Beta-endorphin Y150 3.33x33 TM3 Van der Waals
Beta-endorphin Y150 3.33x33 TM3 hydrophobic
Beta-endorphin M153 3.36x36 TM3 Van der Waals
Beta-endorphin R213 ECL2 Van der Waals
Beta-endorphin D218 ECL2 polar (charge-assisted hydrogen bond)
Beta-endorphin C219 45.50x50 ECL2 Van der Waals
Beta-endorphin C219 45.50x50 ECL2 hydrophobic
Beta-endorphin T220 45.51x51 ECL2 Van der Waals
Beta-endorphin T220 45.51x51 ECL2 polar (hydrogen bond)
Beta-endorphin V238 5.42x43 TM5 Van der Waals
Beta-endorphin W320 7.35x34 TM7 polar (hydrogen bond)
Beta-endorphin W320 7.35x34 TM7 Van der Waals
Beta-endorphin I324 7.39x38 TM7 hydrophobic
Beta-endorphin I324 7.39x38 TM7 Van der Waals
Beta-endorphin Y328 7.43x42 TM7 polar (hydrogen bond)

NGL is a WebGL based 3D viewer powered by MMTF.

Download PDB file

Snake plot — Download: PNG | SVG
ICL1 T K M K ICL1ECL1 T W P F ECL1ICL2 P V K A L D F R ICL2ECL2 T T K Y R Q G S I D C T L T F S H ECL2ICL3 R M L S G ICL3ECL3 T I P E ECL3N-term M D S S A A P T N A S N C T D A L A Y S S C S P A P S P G S W V N L S H L D G N L S D P C G P N R T D L G G R D S L C P P T G S P S N-termC-term P T S S N I E Q Q N S T R I R Q N T R D H P S T A N T V D R T N H Q L E N L E A E T A P L P C-term M I T A I T I M A L Y S I V C V V G L F G N F L V M Y V I V R Y T A T N I Y I F N L A L A D A L A T S T L P F Q S V N Y L M G G T I L C K I V I S I D Y Y N M F T S I F T L C T M S V D R Y I A V C H T P R N A K I I N V C N W I L S S A I G L P V M F M A P T W Y W E N L L K I C V F I F A F I M P V L I I T V C Y G L M I L R L K S V S K E K D R N L R R I T R M V L V V V A V F I V C W T P I H I Y V I I K A L V T T F Q T V S W H F C I A L G Y T N S C L N P V L Y A F L D E N F R E F K R C F C I
Helix box plot — Download: PNG | SVG F N G F L G V V C V I S Y L A M I T I A 1 F N L A L A D A L A T S T L P F Q S V N 2 T C L T F I S T F M N Y Y D I S I V I K 3 A K I I N V C N W I L S S A I G L P V M 4 Y C V T I I L V P M I F A F I F V C I K L 5 L V V V A V F I V C W T P I H I Y V I I 6 V P N L C S N T Y G L A I C F H W S V 7

GPCRdb(A)
GPCRdb(A)
μ receptor
TM1
1x32 1.32x32 A70
1x33 1.33x33 I71
TM2
2x63 2.63x63 N129
2x65 2.65x65 L131
2x67 2.67x67 G133
TM3
3x28 3.28x28 V145
3x29 3.29x29 I146
3x32 3.32x32 D149
3x33 3.33x33 Y150
3x36 3.36x36 M153
ECL2
45x50 45.50x50 C219
45x51 45.51x51 T220
TM5
5x43 5.42x43 V238
TM7
7x34 7.35x34 W320
7x38 7.39x38 I324
7x42 7.43x42 Y328