PDB
8F7Q
Resolution
3.2 Å
Released
Dec. 14, 2022
Receptor
μ
Class
A
Species
Homo sapiens
Ligand
Function
Beta-endorphin
Agonist
Reference
10.1016/J.CELL.2022.12.026

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Ligand Amino Acid Generic Number Segment Interaction Type
Beta-endorphin S66 N-term Van der Waals
Beta-endorphin M67 1.29x29 TM1 hydrophobic
Beta-endorphin A70 1.32x32 TM1 hydrophobic
Beta-endorphin I71 1.33x33 TM1 hydrophobic
Beta-endorphin M74 1.36x36 TM1 Van der Waals
Beta-endorphin Q126 2.60x60 TM2 Van der Waals
Beta-endorphin N129 2.63x63 TM2 polar (hydrogen bond)
Beta-endorphin Y130 2.64x64 TM2 Van der Waals
Beta-endorphin L131 2.65x65 TM2 hydrophobic
Beta-endorphin L131 2.65x65 TM2 polar (hydrogen bond with backbone)
Beta-endorphin M132 2.66x66 TM2 Van der Waals
Beta-endorphin G133 2.67x67 TM2 Van der Waals
Beta-endorphin W135 23.50x50 ECL1 Van der Waals
Beta-endorphin V145 3.28x28 TM3 hydrophobic
Beta-endorphin I146 3.29x29 TM3 hydrophobic
Beta-endorphin D149 3.32x32 TM3 polar (hydrogen bond)
Beta-endorphin D149 3.32x32 TM3 polar (charge-charge)
Beta-endorphin Y150 3.33x33 TM3 hydrophobic
Beta-endorphin M153 3.36x36 TM3 hydrophobic
Beta-endorphin R213 ECL2 polar (charge-charge)
Beta-endorphin D218 ECL2 polar (hydrogen bond)
Beta-endorphin D218 ECL2 polar (charge-charge)
Beta-endorphin C219 45.50x50 ECL2 hydrophobic
Beta-endorphin T220 45.51x51 ECL2 polar (hydrogen bond)
Beta-endorphin K235 5.39x40 TM5 Van der Waals
Beta-endorphin V238 5.42x43 TM5 hydrophobic
Beta-endorphin I298 6.51x51 TM6 hydrophobic
Beta-endorphin V302 6.55x55 TM6 Van der Waals
Beta-endorphin K305 6.58x58 TM6 Van der Waals
Beta-endorphin W320 7.35x34 TM7 hydrophobic
Beta-endorphin W320 7.35x34 TM7 polar (hydrogen bond)
Beta-endorphin I324 7.39x38 TM7 Van der Waals
Beta-endorphin Y328 7.43x42 TM7 Van der Waals

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Snake plot — Download: PNG | SVG
ICL1 T K M K ICL1ECL1 T W P F ECL1ICL2 P V K A L D F R ICL2ECL2 T T K Y R Q G S I D C T L T F S H ECL2ICL3 R M L S G ICL3ECL3 T I P E ECL3N-term M D S S A A P T N A S N C T D A L A Y S S C S P A P S P G S W V N L S H L D G N L S D P C G P N R T D L G G R D S L C P P T G S P S N-termC-term P T S S N I E Q Q N S T R I R Q N T R D H P S T A N T V D R T N H Q L E N L E A E T A P L P C-term M I T A I T I M A L Y S I V C V V G L F G N F L V M Y V I V R Y T A T N I Y I F N L A L A D A L A T S T L P F Q S V N Y L M G G T I L C K I V I S I D Y Y N M F T S I F T L C T M S V D R Y I A V C H T P R N A K I I N V C N W I L S S A I G L P V M F M A P T W Y W E N L L K I C V F I F A F I M P V L I I T V C Y G L M I L R L K S V S K E K D R N L R R I T R M V L V V V A V F I V C W T P I H I Y V I I K A L V T T F Q T V S W H F C I A L G Y T N S C L N P V L Y A F L D E N F R E F K R C F C I
Helix box plot — Download: PNG | SVG F N G F L G V V C V I S Y L A M I T I A 1 F N L A L A D A L A T S T L P F Q S V N 2 T C L T F I S T F M N Y Y D I S I V I K 3 A K I I N V C N W I L S S A I G L P V M 4 Y C V T I I L V P M I F A F I F V C I K L 5 L V V V A V F I V C W T P I H I Y V I I 6 V P N L C S N T Y G L A I C F H W S V 7

GPCRdb(A)
GPCRdb(A)
μ receptor
TM1
1x29 1.29x29 M67
1x32 1.32x32 A70
1x33 1.33x33 I71
1x36 1.36x36 M74
TM2
2x60 2.60x60 Q126
2x63 2.63x63 N129
2x64 2.64x64 Y130
2x65 2.65x65 L131
2x66 2.66x66 M132
2x67 2.67x67 G133
ECL1
23x50 23.50x50 W135
TM3
3x28 3.28x28 V145
3x29 3.29x29 I146
3x32 3.32x32 D149
3x33 3.33x33 Y150
3x36 3.36x36 M153
ECL2
45x50 45.50x50 C219
45x51 45.51x51 T220
TM5
5x40 5.39x40 K235
5x43 5.42x43 V238
TM6
6x51 6.51x51 I298
6x55 6.55x55 V302
6x58 6.58x58 K305
TM7
7x34 7.35x34 W320
7x38 7.39x38 I324
7x42 7.43x42 Y328