PDB
8F7R
Resolution
3.3 Å
Released
Dec. 14, 2022
Receptor
μ
Class
A
Species
Homo sapiens
Ligand
endomorphin-1 (Human)
Function
Agonist
Reference
10.1016/J.CELL.2022.12.026

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Ligand Amino Acid Generic Number Segment Interaction Type
endomorphin-1 (Human) Y77 1.39x39 TM1 hydrophobic
endomorphin-1 (Human) N129 2.63x63 TM2 polar (hydrogen bond)
endomorphin-1 (Human) N129 2.63x63 TM2 polar (hydrogen bond)
endomorphin-1 (Human) Y130 2.64x64 TM2 hydrophobic
endomorphin-1 (Human) Y130 2.64x64 TM2 Van der Waals
endomorphin-1 (Human) W135 23.50x50 ECL1 Van der Waals
endomorphin-1 (Human) W135 23.50x50 ECL1 aromatic (face-to-edge)
endomorphin-1 (Human) V145 3.28x28 TM3 hydrophobic
endomorphin-1 (Human) V145 3.28x28 TM3 Van der Waals
endomorphin-1 (Human) I146 3.29x29 TM3 Van der Waals
endomorphin-1 (Human) I146 3.29x29 TM3 hydrophobic
endomorphin-1 (Human) D149 3.32x32 TM3 Van der Waals
endomorphin-1 (Human) Y150 3.33x33 TM3 hydrophobic
endomorphin-1 (Human) Y150 3.33x33 TM3 Van der Waals
endomorphin-1 (Human) M153 3.36x36 TM3 Van der Waals
endomorphin-1 (Human) M153 3.36x36 TM3 hydrophobic
endomorphin-1 (Human) C219 45.50x50 ECL2 Van der Waals
endomorphin-1 (Human) C219 45.50x50 ECL2 polar (hydrogen bond with backbone)
endomorphin-1 (Human) V238 5.42x43 TM5 hydrophobic
endomorphin-1 (Human) V238 5.42x43 TM5 Van der Waals
endomorphin-1 (Human) I298 6.51x51 TM6 hydrophobic
endomorphin-1 (Human) I298 6.51x51 TM6 Van der Waals
endomorphin-1 (Human) H299 6.52x52 TM6 Van der Waals
endomorphin-1 (Human) V302 6.55x55 TM6 hydrophobic
endomorphin-1 (Human) V302 6.55x55 TM6 Van der Waals
endomorphin-1 (Human) W320 7.35x34 TM7 Van der Waals
endomorphin-1 (Human) W320 7.35x34 TM7 hydrophobic
endomorphin-1 (Human) H321 7.36x35 TM7 aromatic (edge-to-face)
endomorphin-1 (Human) H321 7.36x35 TM7 Van der Waals
endomorphin-1 (Human) I324 7.39x38 TM7 hydrophobic
endomorphin-1 (Human) I324 7.39x38 TM7 Van der Waals
endomorphin-1 (Human) Y328 7.43x42 TM7 polar (hydrogen bond)

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Snake plot — Download: PNG | SVG
ICL1 T K M K ICL1ECL1 T W P F ECL1ICL2 P V K A L D F R ICL2ECL2 T T K Y R Q G S I D C T L T F S H ECL2ICL3 R M L S G ICL3ECL3 T I P E ECL3N-term M D S S A A P T N A S N C T D A L A Y S S C S P A P S P G S W V N L S H L D G N L S D P C G P N R T D L G G R D S L C P P T G S P S N-termC-term P T S S N I E Q Q N S T R I R Q N T R D H P S T A N T V D R T N H Q L E N L E A E T A P L P C-term M I T A I T I M A L Y S I V C V V G L F G N F L V M Y V I V R Y T A T N I Y I F N L A L A D A L A T S T L P F Q S V N Y L M G G T I L C K I V I S I D Y Y N M F T S I F T L C T M S V D R Y I A V C H T P R N A K I I N V C N W I L S S A I G L P V M F M A P T W Y W E N L L K I C V F I F A F I M P V L I I T V C Y G L M I L R L K S V S K E K D R N L R R I T R M V L V V V A V F I V C W T P I H I Y V I I K A L V T T F Q T V S W H F C I A L G Y T N S C L N P V L Y A F L D E N F R E F K R C F C I
Helix box plot — Download: PNG | SVG F N G F L G V V C V I S Y L A M I T I A 1 F N L A L A D A L A T S T L P F Q S V N 2 T C L T F I S T F M N Y Y D I S I V I K 3 A K I I N V C N W I L S S A I G L P V M 4 Y C V T I I L V P M I F A F I F V C I K L 5 L V V V A V F I V C W T P I H I Y V I I 6 V P N L C S N T Y G L A I C F H W S V 7

GPCRdb(A)
GPCRdb(A)
μ receptor
TM1
1x39 1.39x39 Y77
TM2
2x63 2.63x63 N129
2x64 2.64x64 Y130
ECL1
23x50 23.50x50 W135
TM3
3x28 3.28x28 V145
3x29 3.29x29 I146
3x32 3.32x32 D149
3x33 3.33x33 Y150
3x36 3.36x36 M153
ECL2
45x50 45.50x50 C219
TM5
5x43 5.42x43 V238
TM6
6x51 6.51x51 I298
6x52 6.52x52 H299
6x55 6.55x55 V302
TM7
7x34 7.35x34 W320
7x35 7.36x35 H321
7x38 7.39x38 I324
7x42 7.43x42 Y328