Structure information

PTH1 receptor

PROTEIN CLASS

Class B1 (Secretin)

PDB CODE

8FLT

SPECIES

Homo sapiens

RESOLUTION

3.030

PREFERRED CHAIN

R

REFERENCE

10.1016/J.STR.2023.04.002

PUBLICATION DATE

April 26, 2023

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
M-PTH(1-14) E180 1.32x32 TM1 polar (charge-assisted hydrogen bond)
M-PTH(1-14) R181 1.33x33 TM1 Van der Waals
M-PTH(1-14) F184 1.36x36 TM1 hydrophobic
M-PTH(1-14) F184 1.36x36 TM1 Van der Waals
M-PTH(1-14) Y191 1.43x43 TM1 Van der Waals
M-PTH(1-14) Y195 1.47x47 TM1 polar (hydrogen bond)
M-PTH(1-14) Y195 1.47x47 TM1 Van der Waals
M-PTH(1-14) R233 2.60x60 TM2 polar (charge-assisted hydrogen bond)
M-PTH(1-14) D241 2.68x68 TM2 Van der Waals
M-PTH(1-14) Y245 2.72x72 TM2 Van der Waals
M-PTH(1-14) Y245 2.72x72 TM2 polar (hydrogen bond)
M-PTH(1-14) F288 3.36x36 TM3 Van der Waals
M-PTH(1-14) F288 3.36x36 TM3 hydrophobic
M-PTH(1-14) L289 3.37x37 TM3 Van der Waals
M-PTH(1-14) L289 3.37x37 TM3 hydrophobic
M-PTH(1-14) L292 3.40x40 TM3 Van der Waals
M-PTH(1-14) L292 3.40x40 TM3 hydrophobic
M-PTH(1-14) D353 45.52x52 ECL2 polar (charge-assisted hydrogen bond)
M-PTH(1-14) L354 ECL2 Van der Waals
M-PTH(1-14) L354 ECL2 hydrophobic
M-PTH(1-14) S355 ECL2 Van der Waals
M-PTH(1-14) K360 5.36x37 TM5 Van der Waals
M-PTH(1-14) W361 5.37x38 TM5 hydrophobic
M-PTH(1-14) Q364 5.40x40 TM5 polar (hydrogen bond)
M-PTH(1-14) I367 5.43x43 TM5 hydrophobic
M-PTH(1-14) L368 5.44x44 TM5 hydrophobic
M-PTH(1-14) L368 5.44x44 TM5 Van der Waals
M-PTH(1-14) F424 6.56x56 TM6 Van der Waals
M-PTH(1-14) M425 ECL3 Van der Waals
M-PTH(1-14) T427 ECL3 Van der Waals
M-PTH(1-14) T427 ECL3 polar (hydrogen bond with backbone)
M-PTH(1-14) P428 ECL3 Van der Waals
M-PTH(1-14) Y429 ECL3 polar (hydrogen bond)
M-PTH(1-14) Y429 ECL3 Van der Waals
M-PTH(1-14) T430 ECL3 polar (hydrogen bond with backbone)
M-PTH(1-14) T430 ECL3 Van der Waals
M-PTH(1-14) W437 7.35x34 TM7 Van der Waals
M-PTH(1-14) Q440 7.38x37 TM7 Van der Waals
M-PTH(1-14) M441 7.39x38 TM7 hydrophobic
M-PTH(1-14) M441 7.39x38 TM7 Van der Waals
M-PTH(1-14) E444 7.42x41 TM7 Van der Waals
M-PTH(1-14) M445 7.43x42 TM7 polar (hydrogen bond)
M-PTH(1-14) N448 7.46x45 TM7 polar (hydrogen bond)
M-PTH(1-14) N448 7.46x45 TM7 Van der Waals

Ligands

M-PTH(1-14)

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Residue Diagrams

T L S A L S V S Y G V T Y I M G L R D F 1 M H L F L S F M L R A V S I F V K D A V 2 V L I W Y Y N T A L F Y L F F T V A V R 3 Y L W G F T V G F W G L P A V F V A V W V 4 F L I F N L V I S A L I P V Q I I W K K N 5 L V L M P L F G V H Y I V F M A T 6 I A V F F G Q F S N F L M E Y H M Q V 7
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ICL1 R R L H ICL1ECL1 L D E A E R L T E E E L R A I A Q A P P P P A T A A A ECL1ICL2 A F F ICL2ECL2 N T G C W D L S S ECL2ICL3 R E T N A G R C ICL3ECL3 P Y T E V S ECL3N-term M G T A R I A P G L A L L L C C P V L S S A Y A L V D A D D V M T K E E Q I F L L H R A Q A Q C E K R L K E V L Q R P A S I M E S D K G W T S A S T S G K P R K D K A S G K L Y P E S E E D K E A P T G S R Y R G R P C L P E W D H I L C W P L G A P G E V V A V P C P D Y I Y D F N H K G H A Y R R C D R N G S W E L V P G H N R T W A N Y S E C V K N-termC-term S G S S S Y S Y G P M V S H T S V T N V G P R V G L G L P L S P R L L P T A T T N G H P Q L P G H A K P G T P A L E T L E T T P P A M A A P K D D G F L N G S C S G L D E E A S G P E R P P A L L Q E E W E T V M C-term F L T N E T R E R E V F D R L G M I Y T V G Y S V S L A S L T V A V L I L A Y F C T R N Y I H M H L F L S F M L R A V S I F V K D A V L Y S G A T G Y A G C R V A V T F F L Y F L A T N Y Y W I L V E G L Y L H S L I F M S E K K Y L W G F T V F G W G L P A V F V A V W V S V R A T L A G N K K W I I Q V P I L A S I V L N F I L F I N I V R V L A T K L D T R Q Q Y R K L L K S T L V L M P L F G V H Y I V F M A T G T L W Q V Q M H Y E M L F N S F Q G F F V A I I Y C F C N G E I K K W T L K R K V Q A E S W S R A L D F A R
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Residue Table


GPCRdb(A)
GPCRdb(B)
PTH1 receptor
TM1
1x28 1.32x32 E180
1x29 1.33x33 R181
1x32 1.36x36 F184
1x39 1.43x43 Y191
1x43 1.47x47 Y195
TM2
2x53 2.60x60 R233
2x61 2.68x68 D241
2x65 2.72x72 Y245
TM3
3x32 3.36x36 F288
3x33 3.37x37 L289
3x36 3.40x40 L292
ECL2
45x52 45.52x52 D353
TM5
5x41 5.36x37 K360
5x42 5.37x38 W361
5x44 5.40x40 Q364
5x47 5.43x43 I367
5x48 5.44x44 L368
TM6
6x51 6.56x56 F424
TM7
7x30 7.35x34 W437
7x33 7.38x37 Q440
7x34 7.39x38 M441
7x37 7.42x41 E444
7x38 7.43x42 M445
7x41 7.46x45 N448