PDB
8G05
Resolution
3.0 Å
Released
Nov. 1, 2023
Receptor
GPR84
Class
A
Species
Homo sapiens
Ligand
6-n-octylaminouracil
Function
Agonist
Reference
10.1038/S41467-023-41201-0

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Ligand Amino Acid Generic Number Segment Interaction Type
6-n-octylaminouracil Y69 2.53x53 TM2 polar (hydrogen bond)
6-n-octylaminouracil L100 3.32x32 TM3 hydrophobic
6-n-octylaminouracil L100 3.32x32 TM3 Van der Waals
6-n-octylaminouracil F101 3.33x33 TM3 Van der Waals
6-n-octylaminouracil F101 3.33x33 TM3 hydrophobic
6-n-octylaminouracil N104 3.36x36 TM3 Van der Waals
6-n-octylaminouracil N104 3.36x36 TM3 polar (hydrogen bond)
6-n-octylaminouracil F152 4.57x57 TM4 Van der Waals
6-n-octylaminouracil F152 4.57x57 TM4 hydrophobic
6-n-octylaminouracil V165 ECL2 Van der Waals
6-n-octylaminouracil T167 ECL2 Van der Waals
6-n-octylaminouracil T167 ECL2 polar (hydrogen bond)
6-n-octylaminouracil S169 45.51x51 ECL2 polar (hydrogen bond)
6-n-octylaminouracil S169 45.51x51 ECL2 Van der Waals
6-n-octylaminouracil R172 ECL2 polar (charge-assisted hydrogen bond)
6-n-octylaminouracil Y186 5.46x461 TM5 hydrophobic
6-n-octylaminouracil Y186 5.46x461 TM5 Van der Waals
6-n-octylaminouracil Y332 6.48x48 TM6 Van der Waals
6-n-octylaminouracil Y332 6.48x48 TM6 hydrophobic
6-n-octylaminouracil F335 6.51x51 TM6 hydrophobic
6-n-octylaminouracil F335 6.51x51 TM6 Van der Waals
6-n-octylaminouracil L336 6.52x52 TM6 hydrophobic
6-n-octylaminouracil L336 6.52x52 TM6 Van der Waals
6-n-octylaminouracil A356 7.39x38 TM7 Van der Waals
6-n-octylaminouracil T359 7.42x41 TM7 polar (hydrogen bond)
6-n-octylaminouracil W360 7.43x42 TM7 polar (hydrogen bond)
6-n-octylaminouracil W360 7.43x42 TM7 Van der Waals

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ICL1 P K L R ICL1ECL1 L H W R T ECL1ICL2 P K L F P Q V F ICL2ECL2 I L V P V V C T C S F D R I R ECL2ICL3 L R Q A S I H S N H V A R T D E A M P G R F Q E L D S R L A S G G P S E G I S S E P V S A A T T Q T L E G D S S E V G D Q I N S K R A K Q M A E K S P P E A S A K A Q P I K G A R R A ICL3ECL3 R V Q A P R ECL3N-term M W N S S D A N F S C Y H E S V L N-termC-term G P R S F H R L H C-term G Y R Y V A V S W G V V V A V T G T V G N V L T L L A L A I Q T R F N L L I A N L T L A D L L Y C T L L Q P F S V D T Y L H G A T F C R V F G L L L F A S N S V S I L T L C L I A L G R Y L L I A H S A K G I V L A L V S T W V V G V A S F A P L W P I Y G R P Y T T I L M G I Y F V L G L S S V G I F Y C L I H R Q V K R A A Q A L D Q Y K P D S S S E F G K V T R M C F A V F L C F A L S Y I P F L L L N I L D A V V H M L A A N L T W L N G C I N P V L Y A A M N R Q Y G S F R Q A I L K R
Helix box plot — Download: PNG | SVG V N G V T G T V A V V V G W S V A V Y R 1 A N L T L A D L L Y C L T L Q P F S V D T 2 L C L T L I S V S N S A F L L L G F V R 3 I V L A L V S T W V V G V A S F A P L 4 Y F I G V S S L G L V F Y I G M L I T T Y 5 F A V F L C F A L S Y I P F L L L N I L 6 V P N I C G N L W T L N A A L M H V V 7

GPCRdb(A)
GPCRdb(A)
GPR84
TM2
2x53 2.53x53 Y69
TM3
3x32 3.32x32 L100
3x33 3.33x33 F101
3x36 3.36x36 N104
TM4
4x57 4.57x57 F152
ECL2
45x51 45.51x51 S169
TM5
5x461 5.46x461 Y186
TM6
6x48 6.48x48 Y332
6x51 6.51x51 F335
6x52 6.52x52 L336
TM7
7x38 7.39x38 A356
7x41 7.42x41 T359
7x42 7.43x42 W360