PDB
8GDA
Resolution
3.3 Å
Released
Jan. 10, 2024
Receptor
EP4
Class
A
Species
Homo sapiens
Ligand
L902688
Function
Agonist
Reference
10.1073/PNAS.2216329120

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Ligand Amino Acid Generic Number Segment Interaction Type
L902688 V72 2.57x57 TM2 hydrophobic
L902688 T76 2.61x61 TM2 polar (hydrogen bond)
L902688 T76 2.61x61 TM2 Van der Waals
L902688 Y80 2.65x65 TM2 Van der Waals
L902688 Y80 2.65x65 TM2 polar (hydrogen bond)
L902688 L99 3.32x32 TM3 Van der Waals
L902688 L99 3.32x32 TM3 hydrophobic
L902688 F102 3.35x35 TM3 Van der Waals
L902688 S103 3.36x36 TM3 Van der Waals
L902688 T168 ECL2 Van der Waals
L902688 W169 ECL2 Van der Waals
L902688 W169 ECL2 hydrophobic
L902688 L312 7.36x35 TM7 Van der Waals
L902688 R316 7.40x39 TM7 polar (charge-assisted hydrogen bond)
L902688 A318 7.42x41 TM7 hydrophobic
L902688 A318 7.42x41 TM7 Van der Waals
L902688 S319 7.43x42 TM7 Van der Waals
L902688 P322 7.46x46 TM7 hydrophobic

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ICL1 R K E Q K E ICL1ECL1 G Q W P G ECL1ICL2 A Y F Y S H Y V ICL2ECL2 L G S S R L Q Y P D T W C F I D W T T N ECL2ICL3 S L G T E Q H H A A A A A S V A S R G H P A A S P A L P R L S D F R R R R S F ICL3ECL3 Q P S L E R E V S K ECL3N-term M S T P G V N S S A S L S P D R L N-termC-term L F C R I G G S R R E R S G Q H C S D S Q R T S S A M S G H S R S F I S R E L K E I S S T S Q T L L P D L S L P D L S E N G L G G R N L L P G V P G M G L A Q E D T T S L R T L R I S E T S D S S Q G Q D S E S V L L V D E A G G S G R A G P A P K G S S L Q V T F P S E T L N L S E K C I C-term N S P V T I P A V M F I F G V V G N L V A I V V L C K S T T F Y T L V C G L A V T D L L G T L L V S P V T I A T Y M K G Q P L C E Y S T F I L L F F S L S G L S I I C A M S V E R Y L A I N H D K R L A G L T L F A V Y A S N V L F C A L P N M G V T A H A A Y S Y M Y A G F S S F L I L A T V L C N V L V C G A L L R M H R Q F M R R T R R I A G A E I Q M V I L L I A T S L V V L I C S I P L V V R V F V N Q L Y N P D L Q A I R I A S V N P I L D P W I Y I L L R K T A I E V L S K K I K C
Helix box plot — Download: PNG | SVG L N G V V G F I F M V A P I T V P S N 1 C G L A V T D L L G T L L V S P V T I A 2 A C I I S L G S L S F F L L I F T S Y E 3 A G L T L F A V Y A S N V L F C A L P N 4 N C L V T A L I L F S S F G A Y M Y S Y 5 I A T S L V V L I C S I P L V V R V F V 6 W P D L I P N V S A I R I A Q L D P N 7

GPCRdb(A)
GPCRdb(A)
EP4 receptor
TM2
2x57 2.57x57 V72
2x61 2.61x61 T76
2x65 2.65x65 Y80
TM3
3x32 3.32x32 L99
3x35 3.35x35 F102
3x36 3.36x36 S103
TM7
7x35 7.36x35 L312
7x39 7.40x39 R316
7x41 7.42x41 A318
7x42 7.43x42 S319
7x46 7.46x46 P322