PDB
8GGV
Resolution
3.5 Å
Released
March 6, 2024
Receptor
β2
Class
A
Species
Homo sapiens
Ligand
c-Epi
Function
Agonist
Reference
10.1038/S41586-024-07153-1

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Ligand Amino Acid Generic Number Segment Interaction Type
c-Epi D113 3.32x32 TM3 polar (charge-assisted hydrogen bond)
c-Epi V114 3.33x33 TM3 hydrophobic
c-Epi V117 3.36x36 TM3 Van der Waals
c-Epi V117 3.36x36 TM3 hydrophobic
c-Epi F193 45.52x52 ECL2 Van der Waals
c-Epi F193 45.52x52 ECL2 hydrophobic
c-Epi S203 5.42x43 TM5 polar (hydrogen bond)
c-Epi S203 5.42x43 TM5 Van der Waals
c-Epi F289 6.51x51 TM6 Van der Waals
c-Epi F289 6.51x51 TM6 aromatic (edge-to-face)
c-Epi F290 6.52x52 TM6 hydrophobic
c-Epi Y308 7.35x34 TM7 Van der Waals
c-Epi N312 7.39x38 TM7 polar (hydrogen bond)
c-Epi Y316 7.43x42 TM7 Van der Waals

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Snake plot — Download: PNG | SVG
ICL1 E R L Q ICL1ECL1 M W T F ECL1ICL2 P F K Y Q S L L ICL2ECL2 W Y R A T H Q E A I N C Y A N E T C C D F F T ECL2ICL3 G R F H V Q N L S Q V E Q D G R T G H G L R R S ICL3ECL3 D N L I ECL3N-term M G Q P G N G S A F L L A P N G S H A P D H D V T N-termC-term L R R S S L K A Y G N G Y S S N G N T G E Q S G Y H V E Q E K E N K L L C E D L P G T E D F V G H Q G T V P S D N I D S Q G R N C S T N D S L L C-term Q E R D E V W V V G M G I V M S L I V L A I V F G N V L V I T A I A K F T V T N Y F I T S L A C A D L V M G L A V V P F G A A H I L M K G N F W C E F W T S I D V L C V T A S I E T L C V I A V D R Y F A I T S T K N K A R V I I L M V W I V S G L T S F L P I Q M H N Q A Y A I A S S I V S F Y V P L V I M V F V Y S R V F Q E A K R Q L Q K I D K S E S K F C L K E H K A L K T L G I I M G T F T L C W L P F F I V N I V H V I Q R K E V Y I L L N W I G Y V N S G F N P L I Y C R S P D F Q E F R I A L L C
Helix box plot — Download: PNG | SVG V N G F V I A L V I L S M V I G M G V V 1 T S L A C A D L V M G A L V V P F G A A H 2 V C L T E I S A T V C L V D I S T W F E 3 A R V I I L M V W I V S G L T S F L P I 4 Y V F V M I V L P V Y F S V I S S A I A Y 5 G I I M G T F T L C W L P F F I V N I V 6 L P N F G S N V Y G I W N L L I Y V E 7

GPCRdb(A)
GPCRdb(A)
β2-adrenoceptor
TM3
3x32 3.32x32 D113
3x33 3.33x33 V114
3x36 3.36x36 V117
ECL2
45x52 45.52x52 F193
TM5
5x43 5.42x43 S203
TM6
6x51 6.51x51 F289
6x52 6.52x52 F290
TM7
7x34 7.35x34 Y308
7x38 7.39x38 N312
7x42 7.43x42 Y316