Ligand
Function
Agonist
Reference
| Ligand | Amino Acid | Generic Number | Segment | Interaction Type |
|---|---|---|---|---|
| GRP(14-27) | C93 | 2.57x56 | TM2 | Van der Waals |
| GRP(14-27) | D97 | 2.61x60 | TM2 | Van der Waals |
| GRP(14-27) | R100 | 2.64x63 | TM2 | aromatic (pi-cation) |
| GRP(14-27) | Y101 | 2.65x64 | TM2 | hydrophobic |
| GRP(14-27) | D104 | ECL1 | Van der Waals | |
| GRP(14-27) | R105 | 23.49x49 | ECL1 | Van der Waals |
| GRP(14-27) | W106 | 23.50x50 | ECL1 | Van der Waals |
| GRP(14-27) | P117 | 3.29x29 | TM3 | Van der Waals |
| GRP(14-27) | Q120 | 3.32x32 | TM3 | Van der Waals |
| GRP(14-27) | L121 | 3.33x33 | TM3 | Van der Waals |
| GRP(14-27) | V124 | 3.36x36 | TM3 | Van der Waals |
| GRP(14-27) | E175 | 4.60x61 | TM4 | Van der Waals |
| GRP(14-27) | F193 | ECL2 | hydrophobic | |
| GRP(14-27) | I194 | ECL2 | Van der Waals | |
| GRP(14-27) | S195 | ECL2 | polar (hydrogen bond) | |
| GRP(14-27) | P198 | 45.52x52 | ECL2 | Van der Waals |
| GRP(14-27) | S214 | 5.42x43 | TM5 | Van der Waals |
| GRP(14-27) | W277 | 6.48x48 | TM6 | hydrophobic |
| GRP(14-27) | N280 | 6.51x51 | TM6 | polar (hydrogen bond) |
| GRP(14-27) | Y284 | 6.55x55 | TM6 | hydrophobic |
| GRP(14-27) | R287 | 6.58x58 | TM6 | polar (hydrogen bond) |
| GRP(14-27) | D295 | ECL3 | Van der Waals | |
| GRP(14-27) | T296 | ECL3 | polar (hydrogen bond) | |
| GRP(14-27) | H300 | 7.31x30 | TM7 | Van der Waals |
| GRP(14-27) | F301 | 7.32x31 | TM7 | hydrophobic |
| GRP(14-27) | F301 | 7.32x31 | TM7 | aromatic (face-to-face) |
| GRP(14-27) | R308 | 7.39x38 | TM7 | polar (charge-charge) |
| GRP(14-27) | R308 | 7.39x38 | TM7 | polar (hydrogen bond) |
| GRP(14-27) | A311 | 7.42x41 | TM7 | hydrophobic |
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|
GPCRdb(A)
|
GPCRdb(A)
|
BB2 receptor
|
|---|---|---|
| TM2 | ||
| 2x56 | 2.57x56 | C93 |
| 2x60 | 2.61x60 | D97 |
| 2x63 | 2.64x63 | R100 |
| 2x64 | 2.65x64 | Y101 |
| ECL1 | ||
| 23x49 | 23.49x49 | R105 |
| 23x50 | 23.50x50 | W106 |
| TM3 | ||
| 3x29 | 3.29x29 | P117 |
| 3x32 | 3.32x32 | Q120 |
| 3x33 | 3.33x33 | L121 |
| 3x36 | 3.36x36 | V124 |
| TM4 | ||
| 4x61 | 4.60x61 | E175 |
| ECL2 | ||
| 45x52 | 45.52x52 | P198 |
| TM5 | ||
| 5x43 | 5.42x43 | S214 |
| TM6 | ||
| 6x48 | 6.48x48 | W277 |
| 6x51 | 6.51x51 | N280 |
| 6x55 | 6.55x55 | Y284 |
| 6x58 | 6.58x58 | R287 |
| TM7 | ||
| 7x30 | 7.31x30 | H300 |
| 7x31 | 7.32x31 | F301 |
| 7x38 | 7.39x38 | R308 |
| 7x41 | 7.42x41 | A311 |