PDB
8H8J
Resolution
3.2 Å
Released
Feb. 8, 2023
Receptor
GPR35
Class
A
Species
Homo sapiens
Ligands
Function
lodoxamide
Agonist
Calcium
PAM
Reference
10.1038/S41421-022-00499-8
lodoxamide Calcium

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Ligand Amino Acid Generic Number Segment Interaction Type
lodoxamide L13 N-term Van der Waals
lodoxamide V76 2.60x60 TM2 Van der Waals
lodoxamide L77 2.61x61 TM2 Van der Waals
lodoxamide L80 ECL1 hydrophobic
lodoxamide R100 3.36x36 TM3 polar (charge-charge)
lodoxamide F163 45.51x51 ECL2 hydrophobic
lodoxamide R164 45.52x52 ECL2 polar (charge-charge)
lodoxamide L237 6.55x55 TM6 Van der Waals
lodoxamide R240 6.58x58 TM6 polar (hydrogen bond)
lodoxamide R240 6.58x58 TM6 polar (charge-charge)
Calcium R255 7.32x31 TM7 Van der Waals
lodoxamide L258 7.35x34 TM7 hydrophobic
lodoxamide Y259 7.36x35 TM7 hydrophobic
lodoxamide S262 7.39x38 TM7 Van der Waals

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NGL is a WebGL based 3D viewer powered by MMTF.

Download PDB file

Snake plot — Download: PNG | SVG
ICL1 M Q Q W ICL1ECL1 L R D T S D ECL1ICL2 P L R A R G L R ICL2ECL2 G G F C F R S T R H N F N S ECL2ICL3 P P T ICL3ECL3 G W N A C ECL3N-term M N G T Y N T C G S S D L T W N-termC-term V A P S A K A H K S Q D S L C V T L A C-term P P A I K L G F Y A Y L G V L L V L G L L L N S L A L W V F C C R T E T R I Y M T N L A V A D L C L L C T L P F V L H S T P L C Q L S Q G I Y L T N R Y M S I S L V T A I A V D R Y V A V R H S P R Q A A A V C A V L W V L V I G S L V A R W L L G I Q E M A F P L L G F Y L P L A V V V F C S L K V V T A L A Q R D V G Q A E A T R K A A R M V W A N L L V F V V C F L P L H V G L T V R L A V A L L E T I R R A L Y I T S K L S D A N C C L D A I C Y Y Y M A K E S A L F Q E A A
Helix box plot — Download: PNG | SVG S N L L L G L V L L V G L Y A Y F G L K 1 T N L A V A D L C L L C T L P F V L H S 2 A T V L S I S M Y R N T L Y I G Q S L Q 3 A A A V C A V L W V L V I G S L V A R W 4 S C F V V V A L P L Y F G L L P F A M 5 W A N L L V F V V C F L P L H V G L T V 6 I A D L C C N A D S L K S T I Y L A R 7

GPCRdb(A)
GPCRdb(A)
GPR35
TM2
2x60 2.60x60 V76
2x61 2.61x61 L77
TM3
3x36 3.36x36 R100
ECL2
45x51 45.51x51 F163
45x52 45.52x52 R164
TM6
6x55 6.55x55 L237
6x58 6.58x58 R240
TM7
7x31 7.32x31 R255
7x34 7.35x34 L258
7x35 7.36x35 Y259
7x38 7.39x38 S262