Structure information

PTH1 receptor

PROTEIN CLASS

Class B1 (Secretin)

PDB CODE

8HAF

SPECIES

Homo sapiens

RESOLUTION

3.250

PREFERRED CHAIN

R

REFERENCE

10.1038/S41401-022-01032-Z

PUBLICATION DATE

Dec. 21, 2022

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
PTHrP-(1-36) V31 N-term hydrophobic
PTHrP-(1-36) M32 N-term polar (hydrogen bond with backbone)
PTHrP-(1-36) M32 N-term Van der Waals
PTHrP-(1-36) T33 N-term Van der Waals
PTHrP-(1-36) T33 N-term polar (hydrogen bond)
PTHrP-(1-36) K34 N-term Van der Waals
PTHrP-(1-36) E35 N-term polar (charge-assisted hydrogen bond)
PTHrP-(1-36) D113 N-term Van der Waals
PTHrP-(1-36) H114 N-term Van der Waals
PTHrP-(1-36) Y136 N-term hydrophobic
PTHrP-(1-36) Y136 N-term Van der Waals
PTHrP-(1-36) D137 N-term polar (charge-assisted hydrogen bond)
PTHrP-(1-36) E155 N-term Van der Waals
PTHrP-(1-36) E155 N-term polar (hydrogen bond with backbone)
PTHrP-(1-36) N161 N-term polar (hydrogen bond with backbone)
PTHrP-(1-36) N161 N-term Van der Waals
PTHrP-(1-36) W164 N-term Van der Waals
PTHrP-(1-36) W164 N-term hydrophobic
PTHrP-(1-36) A165 N-term Van der Waals
PTHrP-(1-36) N166 N-term Van der Waals
PTHrP-(1-36) Y167 N-term Van der Waals
PTHrP-(1-36) Y167 N-term polar (hydrogen bond with backbone)
PTHrP-(1-36) S168 N-term polar (hydrogen bond with backbone)
PTHrP-(1-36) S168 N-term polar (hydrogen bond)
PTHrP-(1-36) F173 N-term Van der Waals
PTHrP-(1-36) E180 1.32x32 TM1 polar (charge-assisted hydrogen bond)
PTHrP-(1-36) R181 1.33x33 TM1 Van der Waals
PTHrP-(1-36) F184 1.36x36 TM1 Van der Waals
PTHrP-(1-36) F184 1.36x36 TM1 hydrophobic
PTHrP-(1-36) L187 1.39x39 TM1 hydrophobic
PTHrP-(1-36) L187 1.39x39 TM1 Van der Waals
PTHrP-(1-36) Y195 1.47x47 TM1 Van der Waals
PTHrP-(1-36) Y195 1.47x47 TM1 polar (hydrogen bond)
PTHrP-(1-36) R233 2.60x60 TM2 polar (charge-assisted hydrogen bond)
PTHrP-(1-36) K240 2.67x67 TM2 Van der Waals
PTHrP-(1-36) Y245 ECL1 Van der Waals
PTHrP-(1-36) Y245 ECL1 hydrophobic
PTHrP-(1-36) F288 3.36x36 TM3 Van der Waals
PTHrP-(1-36) F288 3.36x36 TM3 hydrophobic
PTHrP-(1-36) L289 3.37x37 TM3 Van der Waals
PTHrP-(1-36) L292 3.40x40 TM3 Van der Waals
PTHrP-(1-36) L292 3.40x40 TM3 hydrophobic
PTHrP-(1-36) Y296 3.44x44 TM3 Van der Waals
PTHrP-(1-36) D353 45.52x52 ECL2 polar (hydrogen bond with backbone)
PTHrP-(1-36) D353 45.52x52 ECL2 Van der Waals
PTHrP-(1-36) L354 ECL2 Van der Waals
PTHrP-(1-36) L354 ECL2 hydrophobic
PTHrP-(1-36) S355 ECL2 Van der Waals
PTHrP-(1-36) S355 ECL2 polar (hydrogen bond with backbone)
PTHrP-(1-36) K360 5.36x37 TM5 Van der Waals
PTHrP-(1-36) Q364 5.40x40 TM5 polar (hydrogen bond)
PTHrP-(1-36) Q364 5.40x40 TM5 polar (hydrogen bond)
PTHrP-(1-36) I367 5.43x43 TM5 hydrophobic
PTHrP-(1-36) I367 5.43x43 TM5 Van der Waals
PTHrP-(1-36) L368 5.44x44 TM5 hydrophobic
PTHrP-(1-36) L368 5.44x44 TM5 Van der Waals
PTHrP-(1-36) F424 6.56x56 TM6 Van der Waals
PTHrP-(1-36) T427 ECL3 Van der Waals
PTHrP-(1-36) Y429 ECL3 polar (hydrogen bond)
PTHrP-(1-36) T430 ECL3 Van der Waals
PTHrP-(1-36) W437 7.35x34 TM7 polar (hydrogen bond)
PTHrP-(1-36) W437 7.35x34 TM7 Van der Waals
PTHrP-(1-36) M441 7.39x38 TM7 polar (hydrogen bond)
PTHrP-(1-36) E444 7.42x41 TM7 Van der Waals
PTHrP-(1-36) M445 7.43x42 TM7 Van der Waals
PTHrP-(1-36) M445 7.43x42 TM7 hydrophobic

Ligands

PTHrP-(1-36)

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Residue Diagrams

T L S A L S V S Y G V T Y I M G L R D F 1 M H L F L S F M L R A V S I F V K D A V 2 V L I W Y Y N T A L F Y L F F T V A V R 3 Y L W G F T V G F W G L P A V F V A V W V 4 F L I F N L V I S A L I P V Q I I W K K N 5 L V L M P L F G V H Y I V F M A T 6 I A V F F G Q F S N F L M E Y H M Q V 7
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ICL1 R R L H ICL1ECL1 L D E A E R L T E E E L R A I A Q A P P P P A T A A A ECL1ICL2 A F F ICL2ECL2 N T G C W D L S S ECL2ICL3 R E T N A G R C ICL3ECL3 P Y T E V S ECL3N-term M G T A R I A P G L A L L L C C P V L S S A Y A L V D A D D V M T K E E Q I F L L H R A Q A Q C E K R L K E V L Q R P A S I M E S D K G W T S A S T S G K P R K D K A S G K L Y P E S E E D K E A P T G S R Y R G R P C L P E W D H I L C W P L G A P G E V V A V P C P D Y I Y D F N H K G H A Y R R C D R N G S W E L V P G H N R T W A N Y S E C V K N-termC-term S G S S S Y S Y G P M V S H T S V T N V G P R V G L G L P L S P R L L P T A T T N G H P Q L P G H A K P G T P A L E T L E T T P P A M A A P K D D G F L N G S C S G L D E E A S G P E R P P A L L Q E E W E T V M C-term F L T N E T R E R E V F D R L G M I Y T V G Y S V S L A S L T V A V L I L A Y F C T R N Y I H M H L F L S F M L R A V S I F V K D A V L Y S G A T G Y A G C R V A V T F F L Y F L A T N Y Y W I L V E G L Y L H S L I F M S E K K Y L W G F T V F G W G L P A V F V A V W V S V R A T L A G N K K W I I Q V P I L A S I V L N F I L F I N I V R V L A T K L D T R Q Q Y R K L L K S T L V L M P L F G V H Y I V F M A T G T L W Q V Q M H Y E M L F N S F Q G F F V A I I Y C F C N G E I K K W T L K R K V Q A E S W S R A L D F A R
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Residue Table


GPCRdb(A)
GPCRdb(B)
PTH1 receptor
TM1
1x28 1.32x32 E180
1x29 1.33x33 R181
1x32 1.36x36 F184
1x35 1.39x39 L187
1x43 1.47x47 Y195
TM2
2x53 2.60x60 R233
2x60 2.67x67 K240
TM3
3x32 3.36x36 F288
3x33 3.37x37 L289
3x36 3.40x40 L292
3x40 3.44x44 Y296
ECL2
45x52 45.52x52 D353
TM5
5x41 5.36x37 K360
5x44 5.40x40 Q364
5x47 5.43x43 I367
5x48 5.44x44 L368
TM6
6x51 6.56x56 F424
TM7
7x30 7.35x34 W437
7x34 7.39x38 M441
7x37 7.42x41 E444
7x38 7.43x42 M445