Structure information

PTH1 receptor

PROTEIN CLASS

Class B1 (Secretin)

PDB CODE

8HAO

SPECIES

Homo sapiens

RESOLUTION

3.760

PREFERRED CHAIN

R

REFERENCE

10.1038/S41401-022-01032-Z

PUBLICATION DATE

Dec. 21, 2022

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
teriparatide M32 N-term polar (hydrogen bond with backbone)
teriparatide M32 N-term Van der Waals
teriparatide K34 N-term Van der Waals
teriparatide Q37 N-term Van der Waals
teriparatide Y136 N-term Van der Waals
teriparatide T163 N-term Van der Waals
teriparatide Y167 N-term Van der Waals
teriparatide E180 1.32x32 TM1 Van der Waals
teriparatide R181 1.33x33 TM1 Van der Waals
teriparatide F184 1.36x36 TM1 hydrophobic
teriparatide F184 1.36x36 TM1 Van der Waals
teriparatide Y195 1.47x47 TM1 Van der Waals
teriparatide Y195 1.47x47 TM1 polar (hydrogen bond)
teriparatide R233 2.60x60 TM2 polar (charge-assisted hydrogen bond)
teriparatide L244 2.71x71 TM2 hydrophobic
teriparatide L244 2.71x71 TM2 Van der Waals
teriparatide F288 3.36x36 TM3 Van der Waals
teriparatide F288 3.36x36 TM3 hydrophobic
teriparatide L289 3.37x37 TM3 Van der Waals
teriparatide L292 3.40x40 TM3 hydrophobic
teriparatide L292 3.40x40 TM3 Van der Waals
teriparatide D353 45.52x52 ECL2 polar (charge-assisted hydrogen bond)
teriparatide D353 45.52x52 ECL2 polar (hydrogen bond with backbone)
teriparatide L354 ECL2 Van der Waals
teriparatide L354 ECL2 hydrophobic
teriparatide S355 ECL2 Van der Waals
teriparatide W361 5.37x38 TM5 Van der Waals
teriparatide Q364 5.40x40 TM5 polar (hydrogen bond)
teriparatide F424 6.56x56 TM6 Van der Waals
teriparatide M425 6.57x57 TM6 polar (hydrogen bond with backbone)
teriparatide M425 6.57x57 TM6 Van der Waals
teriparatide T427 ECL3 polar (hydrogen bond with backbone)
teriparatide T427 ECL3 Van der Waals
teriparatide P428 ECL3 polar (hydrogen bond with backbone)
teriparatide P428 ECL3 Van der Waals
teriparatide Y429 ECL3 polar (hydrogen bond)
teriparatide V432 ECL3 Van der Waals
teriparatide W437 7.35x34 TM7 Van der Waals
teriparatide W437 7.35x34 TM7 polar (hydrogen bond)
teriparatide Q440 7.38x37 TM7 polar (hydrogen bond)
teriparatide M441 7.39x38 TM7 hydrophobic
teriparatide M441 7.39x38 TM7 Van der Waals
teriparatide E444 7.42x41 TM7 polar (charge-assisted hydrogen bond)

Ligands

teriparatide

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Residue Diagrams

T L S A L S V S Y G V T Y I M G L R D F 1 M H L F L S F M L R A V S I F V K D A V 2 V L I W Y Y N T A L F Y L F F T V A V R 3 Y L W G F T V G F W G L P A V F V A V W V 4 F L I F N L V I S A L I P V Q I I W K K N 5 L V L M P L F G V H Y I V F M A T 6 I A V F F G Q F S N F L M E Y H M Q V 7
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ICL1 R R L H ICL1ECL1 L D E A E R L T E E E L R A I A Q A P P P P A T A A A ECL1ICL2 A F F ICL2ECL2 N T G C W D L S S ECL2ICL3 R E T N A G R C ICL3ECL3 P Y T E V S ECL3N-term M G T A R I A P G L A L L L C C P V L S S A Y A L V D A D D V M T K E E Q I F L L H R A Q A Q C E K R L K E V L Q R P A S I M E S D K G W T S A S T S G K P R K D K A S G K L Y P E S E E D K E A P T G S R Y R G R P C L P E W D H I L C W P L G A P G E V V A V P C P D Y I Y D F N H K G H A Y R R C D R N G S W E L V P G H N R T W A N Y S E C V K N-termC-term S G S S S Y S Y G P M V S H T S V T N V G P R V G L G L P L S P R L L P T A T T N G H P Q L P G H A K P G T P A L E T L E T T P P A M A A P K D D G F L N G S C S G L D E E A S G P E R P P A L L Q E E W E T V M C-term F L T N E T R E R E V F D R L G M I Y T V G Y S V S L A S L T V A V L I L A Y F C T R N Y I H M H L F L S F M L R A V S I F V K D A V L Y S G A T G Y A G C R V A V T F F L Y F L A T N Y Y W I L V E G L Y L H S L I F M S E K K Y L W G F T V F G W G L P A V F V A V W V S V R A T L A G N K K W I I Q V P I L A S I V L N F I L F I N I V R V L A T K L D T R Q Q Y R K L L K S T L V L M P L F G V H Y I V F M A T G T L W Q V Q M H Y E M L F N S F Q G F F V A I I Y C F C N G E I K K W T L K R K V Q A E S W S R A L D F A R
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Residue Table


GPCRdb(A)
GPCRdb(B)
PTH1 receptor
TM1
1x28 1.32x32 E180
1x29 1.33x33 R181
1x32 1.36x36 F184
1x43 1.47x47 Y195
TM2
2x53 2.60x60 R233
2x64 2.71x71 L244
TM3
3x32 3.36x36 F288
3x33 3.37x37 L289
3x36 3.40x40 L292
ECL2
45x52 45.52x52 D353
TM5
5x42 5.37x38 W361
5x44 5.40x40 Q364
TM6
6x51 6.56x56 F424
6x52 6.57x57 M425
TM7
7x30 7.35x34 W437
7x33 7.38x37 Q440
7x34 7.39x38 M441
7x37 7.42x41 E444