| Ligand | Amino Acid | Generic Number | Segment | Interaction Type |
|---|---|---|---|---|
| endothelin-1 (Human) | Y68 | N-term | Van der Waals | |
| endothelin-1 (Human) | Q72 | N-term | Van der Waals | |
| endothelin-1 (Human) | T73 | N-term | Van der Waals | |
| endothelin-1 (Human) | K74 | N-term | polar (charge-charge) | |
| endothelin-1 (Human) | K74 | N-term | polar (hydrogen bond) | |
| endothelin-1 (Human) | D133 | 2.57x56 | TM2 | Van der Waals |
| endothelin-1 (Human) | I136 | 2.60x59 | TM2 | hydrophobic |
| endothelin-1 (Human) | N137 | 2.61x60 | TM2 | Van der Waals |
| endothelin-1 (Human) | K140 | 2.64x63 | TM2 | polar (hydrogen bond) |
| endothelin-1 (Human) | L141 | 2.65x64 | TM2 | hydrophobic |
| endothelin-1 (Human) | G144 | ECL1 | polar (hydrogen bond with backbone) | |
| endothelin-1 (Human) | R145 | 23.49x49 | ECL1 | Van der Waals |
| endothelin-1 (Human) | W146 | 23.50x50 | ECL1 | Van der Waals |
| endothelin-1 (Human) | Q165 | 3.32x32 | TM3 | Van der Waals |
| endothelin-1 (Human) | K166 | 3.33x33 | TM3 | polar (hydrogen bond) |
| endothelin-1 (Human) | K166 | 3.33x33 | TM3 | aromatic (pi-cation) |
| endothelin-1 (Human) | K166 | 3.33x33 | TM3 | polar (charge-charge) |
| endothelin-1 (Human) | V169 | 3.36x36 | TM3 | Van der Waals |
| endothelin-1 (Human) | V227 | ECL2 | Van der Waals | |
| endothelin-1 (Human) | F229 | ECL2 | hydrophobic | |
| endothelin-1 (Human) | Y231 | ECL2 | hydrophobic | |
| endothelin-1 (Human) | H236 | ECL2 | Van der Waals | |
| endothelin-1 (Human) | K237 | ECL2 | Van der Waals | |
| endothelin-1 (Human) | T238 | ECL2 | polar (hydrogen bond) | |
| endothelin-1 (Human) | M240 | 45.51x51 | ECL2 | Van der Waals |
| endothelin-1 (Human) | L241 | 45.52x52 | ECL2 | Van der Waals |
| endothelin-1 (Human) | Q252 | 5.35x36 | TM5 | polar (hydrogen bond) |
| endothelin-1 (Human) | K255 | 5.38x39 | TM5 | aromatic (pi-cation) |
| endothelin-1 (Human) | K255 | 5.38x39 | TM5 | polar (hydrogen bond) |
| endothelin-1 (Human) | K255 | 5.38x39 | TM5 | polar (charge-charge) |
| endothelin-1 (Human) | L259 | 5.42x43 | TM5 | hydrophobic |
| endothelin-1 (Human) | Y263 | 5.46x461 | TM5 | Van der Waals |
| endothelin-1 (Human) | W319 | 6.48x48 | TM6 | hydrophobic |
| endothelin-1 (Human) | R326 | 6.55x55 | TM6 | polar (charge-charge) |
| endothelin-1 (Human) | R326 | 6.55x55 | TM6 | polar (hydrogen bond) |
| endothelin-1 (Human) | K330 | 6.59x59 | TM6 | Van der Waals |
| endothelin-1 (Human) | Y333 | ECL3 | Van der Waals | |
| endothelin-1 (Human) | M336 | ECL3 | hydrophobic | |
| endothelin-1 (Human) | L344 | 7.28x27 | TM7 | hydrophobic |
| endothelin-1 (Human) | L348 | 7.32x31 | TM7 | hydrophobic |
| endothelin-1 (Human) | D351 | 7.35x34 | TM7 | Van der Waals |
| endothelin-1 (Human) | Y352 | 7.36x35 | TM7 | hydrophobic |
| endothelin-1 (Human) | I355 | 7.39x38 | TM7 | hydrophobic |
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|
GPCRdb(A)
|
GPCRdb(A)
|
ETA receptor
|
|---|---|---|
| TM2 | ||
| 2x56 | 2.57x56 | D133 |
| 2x59 | 2.60x59 | I136 |
| 2x60 | 2.61x60 | N137 |
| 2x63 | 2.64x63 | K140 |
| 2x64 | 2.65x64 | L141 |
| ECL1 | ||
| 23x49 | 23.49x49 | R145 |
| 23x50 | 23.50x50 | W146 |
| TM3 | ||
| 3x32 | 3.32x32 | Q165 |
| 3x33 | 3.33x33 | K166 |
| 3x36 | 3.36x36 | V169 |
| ECL2 | ||
| 45x51 | 45.51x51 | M240 |
| 45x52 | 45.52x52 | L241 |
| TM5 | ||
| 5x36 | 5.35x36 | Q252 |
| 5x39 | 5.38x39 | K255 |
| 5x43 | 5.42x43 | L259 |
| 5x461 | 5.46x461 | Y263 |
| TM6 | ||
| 6x48 | 6.48x48 | W319 |
| 6x55 | 6.55x55 | R326 |
| 6x59 | 6.59x59 | K330 |
| TM7 | ||
| 7x27 | 7.28x27 | L344 |
| 7x31 | 7.32x31 | L348 |
| 7x34 | 7.35x34 | D351 |
| 7x35 | 7.36x35 | Y352 |
| 7x38 | 7.39x38 | I355 |