PDB
8HDP
Resolution
3.2 Å
Released
Jan. 18, 2023
Receptor
A2B
Class
A
Species
Homo sapiens
Ligand
Function
adenosine
Agonist
Reference
10.1038/S41421-022-00503-1

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Ligand Amino Acid Generic Number Segment Interaction Type
adenosine V85 3.32x32 TM3 Van der Waals
adenosine L86 3.33x33 TM3 Van der Waals
adenosine T89 3.36x36 TM3 Van der Waals
adenosine F173 45.52x52 ECL2 aromatic (face-to-face)
adenosine M179 5.35x37 TM5 Van der Waals
adenosine M182 5.38x40 TM5 Van der Waals
adenosine V250 6.51x51 TM6 Van der Waals
adenosine H251 6.52x52 TM6 polar (hydrogen bond)
adenosine N254 6.55x55 TM6 polar (hydrogen bond)
adenosine N254 6.55x55 TM6 polar (hydrogen bond)
adenosine I276 7.39x38 TM7 Van der Waals
adenosine S279 7.42x41 TM7 Van der Waals
adenosine H280 7.43x42 TM7 polar (hydrogen bond)

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Snake plot — Download: PNG | SVG
ICL1 N T L Q ICL1ECL1 F C T ECL1ICL2 P L R Y K S L V ICL2ECL2 W N S K D S A T N N C T E P W D G T T N E S C C L V K C L F E N V V ECL2ICL3 L M D ICL3ECL3 P A Q G K N K ECL3N-term M L L N-termC-term S G N G Q A G V Q P A L G V G L C-term E T Q D A L Y V A L E L V I A A L S V A G N V L V C A A V G T A T P T N Y F L V S L A A A D V A V G L F A I P F A I T I S L G D F Y G C L F L A C F V L V L T Q S S I F S L L A V A V D R Y L A I C V T G T R A R G V I A V L W V L A F G I G L T P F L G P M S Y M V Y F N F F G C V L P P L L I M L V I Y I K I F L V A C R Q L Q R T E H S R T T L Q R E I H A A K S L A M I V G I F A L C W L P V H A V N C V T L F Q P K W A M N M A I L L S H A N S V V N P I V Y A Y R N R D F H K Y L L V K F R Y T I I S R C Q A D
Helix box plot — Download: PNG | SVG V N G A V S L A A I V L E L A V Y L A D 1 V S L A A A D V A V G F L A I P F A I T I 2 A L L S F I S S Q T L V L V F C A L F L 3 A R G V I A V L W V L A F G I G L T P F 4 Y I V L M I L L P P L V C G F F N F Y V M Y 5 A M I V G I F A L C W L P V H A V N C V 6 I P N V V S N A H S L L I A M N M A W 7

GPCRdb(A)
GPCRdb(A)
A2B receptor
TM3
3x32 3.32x32 V85
3x33 3.33x33 L86
3x36 3.36x36 T89
ECL2
45x52 45.52x52 F173
TM5
5x37 5.35x37 M179
5x40 5.38x40 M182
TM6
6x51 6.51x51 V250
6x52 6.52x52 H251
6x55 6.55x55 N254
TM7
7x38 7.39x38 I276
7x41 7.42x41 S279
7x42 7.43x42 H280