PDB
8HDP
Resolution
3.2 Å
Released
Jan. 18, 2023
Receptor
A2B
Class
A
Species
Homo sapiens
Ligand
adenosine
Function
Agonist
Reference
10.1038/S41421-022-00503-1

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Ligand Amino Acid Generic Number Segment Interaction Type
adenosine F173 45.52x52 ECL2 aromatic (face-to-face)
adenosine M182 5.38x40 TM5 hydrophobic
adenosine V250 6.51x51 TM6 hydrophobic
adenosine H251 6.52x52 TM6 Van der Waals
adenosine H251 6.52x52 TM6 polar (hydrogen bond)
adenosine N254 6.55x55 TM6 polar (hydrogen bond)
adenosine N254 6.55x55 TM6 polar (hydrogen bond)
adenosine I276 7.39x38 TM7 hydrophobic
adenosine I276 7.39x38 TM7 Van der Waals
adenosine H280 7.43x42 TM7 polar (hydrogen bond)
adenosine H280 7.43x42 TM7 Van der Waals

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Snake plot — Download: PNG | SVG
ICL1 N T L Q ICL1ECL1 F C T ECL1ICL2 P L R Y K S L V ICL2ECL2 W N S K D S A T N N C T E P W D G T T N E S C C L V K C L F E N V V ECL2ICL3 L M D ICL3ECL3 P A Q G K N K ECL3N-term M L L N-termC-term S G N G Q A G V Q P A L G V G L C-term E T Q D A L Y V A L E L V I A A L S V A G N V L V C A A V G T A T P T N Y F L V S L A A A D V A V G L F A I P F A I T I S L G D F Y G C L F L A C F V L V L T Q S S I F S L L A V A V D R Y L A I C V T G T R A R G V I A V L W V L A F G I G L T P F L G P M S Y M V Y F N F F G C V L P P L L I M L V I Y I K I F L V A C R Q L Q R T E H S R T T L Q R E I H A A K S L A M I V G I F A L C W L P V H A V N C V T L F Q P K W A M N M A I L L S H A N S V V N P I V Y A Y R N R D F H K Y L L V K F R Y T I I S R C Q A D
Helix box plot — Download: PNG | SVG V N G A V S L A A I V L E L A V Y L A D 1 V S L A A A D V A V G F L A I P F A I T I 2 A L L S F I S S Q T L V L V F C A L F L 3 A R G V I A V L W V L A F G I G L T P F 4 Y I V L M I L L P P L V C G F F N F Y V M Y 5 A M I V G I F A L C W L P V H A V N C V 6 I P N V V S N A H S L L I A M N M A W 7

GPCRdb(A)
GPCRdb(A)
A2B receptor
ECL2
45x52 45.52x52 F173
TM5
5x40 5.38x40 M182
TM6
6x51 6.51x51 V250
6x52 6.52x52 H251
6x55 6.55x55 N254
TM7
7x38 7.39x38 I276
7x42 7.43x42 H280