PDB
8HOC
Resolution
3.0 Å
Released
Dec. 20, 2023
Receptor
H4
Class
A
Species
Homo sapiens
Ligand
imetit
Function
Agonist
Reference
—

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Ligand Amino Acid Generic Number Segment Interaction Type
imetit Y95 3.33x33 TM3 hydrophobic
imetit Y319 6.51x51 TM6 hydrophobic
imetit F344 7.39x38 TM7 polar (hydrogen bond with backbone)
imetit F344 7.39x38 TM7 Van der Waals
imetit Q347 7.42x41 TM7 Van der Waals
imetit W348 7.43x42 TM7 polar (hydrogen bond)

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Snake plot — Download: PNG | SVG
ICL1 K N L R ICL1ECL1 F E W D F ECL1ICL2 A V S Y R T Q H T ICL2ECL2 D E G S E C E P G F F S ECL2ICL3 H P G L T A V S S N I C G H S F R G R L S S R R S L S A S T E V P A S F H S E R Q R R K S S L M F S S R T K M N S N T I A S K M G S F S Q S D S V A L H Q R E ICL3ECL3 S S A T G P K ECL3N-term M P D T N S T I N L N-termC-term K K Q P L P S Q H S R S V S S C-term S L S T R V T L A F F M S L V A F A I M L G N A L V I L A F V V D H R S S Y F F L N L A I S D F F V G V I S I P L Y I P H T L G K E I C V F W L T T D Y L L C T A S V Y N I V L I S Y D R Y L S V S N G V L K I V T L M V A V W V L A F L V N G P M I L V S E S W K E W Y I L A I T S F L E F V I P V I L V A Y F N M N I Y W S L W K R D H L S R C Q S H V E L L R A R R L A K S L A I L L G V F A V C W A P Y S L F T I V L S F Y S V W Y R I A F W L Q W F N S F V N P L L Y P L C H K R F L K F Q K A I F C I
Helix box plot — Download: PNG | SVG A N G L M I A F A V L S M F F A L T V R 1 L N L A I S D F F V G I V S I P L Y I P H 2 L V I N Y V S A T C L L Y D T T L W F V 3 I V T L M V A V W V L A F L V N G P M 4 N F Y A V L I V P I V F E L F S T I A L I 5 A I L L G V F A V C W A P Y S L F T I V 6 L P N V F S N F W Q L W F A I R Y W V 7

GPCRdb(A)
GPCRdb(A)
H4 receptor
TM3
3x33 3.33x33 Y95
TM6
6x51 6.51x51 Y319
TM7
7x38 7.39x38 F344
7x41 7.42x41 Q347
7x42 7.43x42 W348