PDB
8HQM
Resolution
3.0 Å
Released
Oct. 11, 2023
Receptor
GPR132
Class
A
Species
Homo sapiens
Ligand
N-hexadecanoylglycine
Function
Agonist (partial)
Reference
10.1038/S42255-023-00899-4

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Ligand Amino Acid Generic Number Segment Interaction Type
N-hexadecanoylglycine H106 ECL1 polar (hydrogen bond)
N-hexadecanoylglycine H106 ECL1 Van der Waals
N-hexadecanoylglycine E184 ECL2 Van der Waals
N-hexadecanoylglycine T185 ECL2 polar (hydrogen bond)
N-hexadecanoylglycine T185 ECL2 Van der Waals
N-hexadecanoylglycine D188 45.52x52 ECL2 Van der Waals
N-hexadecanoylglycine Q191 ECL2 Van der Waals
N-hexadecanoylglycine E283 7.28x27 TM7 polar (charge-assisted hydrogen bond)
N-hexadecanoylglycine Y287 7.32x31 TM7 Van der Waals
N-hexadecanoylglycine Y287 7.32x31 TM7 hydrophobic

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Snake plot — Download: PNG | SVG
ICL1 L Q G ICL1ECL1 R N Q H R W T L ECL1ICL2 A L E S R G R R ICL2ECL2 E D K E T C F D M L Q M ECL2ICL3 M G L ICL3ECL3 G D R N ECL3N-term M C P M L L K N G Y N G N A T P V T T T A P W A S L G L S A K T C N N V N-termC-term K T D V T R L T H S R D T E E L Q S P V A L A D H Y T F S R P V H P P G S P C P A K R L I E E S C C-term S F E E S R I V L V V V Y S A V C T L G V P A N C L T A W L A L L Q V N V L A V Y L L C L A L C E L L Y T G T L P L W V I Y I G L L A C K V T A Y I F F C N I Y V S I L F L C C I S C D R F V A V V Y R R R T A I L I S A C I F I L V G I V H Y P V F Q T D S R I A G Y Y Y A R F T V G F A I P L S I I A F T N H R I F R S I K Q S S A A Q K A K V K H S A I A V V V I F L V C F A P Y H L V L L V K A A A F S Y Y R A M C G L E E R L Y T A S V V F L C L S T V N G V A D P I I Y V L A T D H V S R W K E S R Q E I H K G W S M
Helix box plot — Download: PNG | SVG C N A P V G L T C V A S Y V V V L V I R 1 L C L A L C E L L Y T G T L P L W V I Y 2 C C L F L I S V Y I N C F F I Y A T V K 3 A I L I S A C I F I L V G I V H Y P V 4 N T F A I I S L P I A F G V T F R A Y Y Y 5 I A V V V I F L V C F A P Y H L V L L V 6 I P D A V G N V T S L C L F V V S A T 7

GPCRdb(A)
GPCRdb(A)
GPR132
ECL2
45x52 45.52x52 D188
TM7
7x27 7.28x27 E283
7x31 7.32x31 Y287