PDB
8HQN
Resolution
3.0 Å
Released
Oct. 11, 2023
Receptor
GPR132
Class
A
Species
Homo sapiens
Ligand
Function
9-hydroxyoctadecadienoic acid
Agonist
Reference
10.1038/S42255-023-00899-4

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Ligand Amino Acid Generic Number Segment Interaction Type
9-hydroxyoctadecadienoic acid F123 3.33x33 TM3 hydrophobic
9-hydroxyoctadecadienoic acid Y127 3.37x37 TM3 Van der Waals
9-hydroxyoctadecadienoic acid H174 4.57x57 TM4 polar (charge-charge)
9-hydroxyoctadecadienoic acid H174 4.57x57 TM4 polar (hydrogen bond)
9-hydroxyoctadecadienoic acid V177 4.60x61 TM4 hydrophobic
9-hydroxyoctadecadienoic acid D188 45.52x52 ECL2 hydrophobic
9-hydroxyoctadecadienoic acid M189 ECL2 Van der Waals
9-hydroxyoctadecadienoic acid L190 ECL2 hydrophobic
9-hydroxyoctadecadienoic acid Y200 5.39x40 TM5 hydrophobic
9-hydroxyoctadecadienoic acid Y200 5.39x40 TM5 polar (hydrogen bond)
9-hydroxyoctadecadienoic acid R203 5.42x43 TM5 polar (charge-charge)
9-hydroxyoctadecadienoic acid Y258 6.51x51 TM6 polar (hydrogen bond)
9-hydroxyoctadecadienoic acid L262 6.55x55 TM6 Van der Waals
9-hydroxyoctadecadienoic acid K265 6.58x58 TM6 Van der Waals
9-hydroxyoctadecadienoic acid F269 6.62x62 TM6 hydrophobic
9-hydroxyoctadecadienoic acid L286 7.31x30 TM7 hydrophobic

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Snake plot — Download: PNG | SVG
ICL1 L Q G ICL1ECL1 R N Q H R W T L ECL1ICL2 A L E S R G R R ICL2ECL2 E D K E T C F D M L Q M ECL2ICL3 M G L ICL3ECL3 G D R N ECL3N-term M C P M L L K N G Y N G N A T P V T T T A P W A S L G L S A K T C N N V N-termC-term K T D V T R L T H S R D T E E L Q S P V A L A D H Y T F S R P V H P P G S P C P A K R L I E E S C C-term S F E E S R I V L V V V Y S A V C T L G V P A N C L T A W L A L L Q V N V L A V Y L L C L A L C E L L Y T G T L P L W V I Y I G L L A C K V T A Y I F F C N I Y V S I L F L C C I S C D R F V A V V Y R R R T A I L I S A C I F I L V G I V H Y P V F Q T D S R I A G Y Y Y A R F T V G F A I P L S I I A F T N H R I F R S I K Q S S A A Q K A K V K H S A I A V V V I F L V C F A P Y H L V L L V K A A A F S Y Y R A M C G L E E R L Y T A S V V F L C L S T V N G V A D P I I Y V L A T D H V S R W K E S R Q E I H K G W S M
Helix box plot — Download: PNG | SVG C N A P V G L T C V A S Y V V V L V I R 1 L C L A L C E L L Y T G T L P L W V I Y 2 C C L F L I S V Y I N C F F I Y A T V K 3 A I L I S A C I F I L V G I V H Y P V 4 N T F A I I S L P I A F G V T F R A Y Y Y 5 I A V V V I F L V C F A P Y H L V L L V 6 I P D A V G N V T S L C L F V V S A T 7

GPCRdb(A)
GPCRdb(A)
GPR132
TM3
3x33 3.33x33 F123
3x37 3.37x37 Y127
TM4
4x57 4.57x57 H174
4x61 4.60x61 V177
ECL2
45x52 45.52x52 D188
TM5
5x40 5.39x40 Y200
5x43 5.42x43 R203
TM6
6x51 6.51x51 Y258
6x55 6.55x55 L262
6x58 6.58x58 K265
6x62 6.62x62 F269
TM7
7x30 7.31x30 L286