Structure information

FSH receptor

PROTEIN CLASS

Class A (Rhodopsin)

PDB CODE

8I2G

SPECIES

Homo sapiens

RESOLUTION

2.800

PREFERRED CHAIN

R

REFERENCE

10.1038/S41467-023-36170-3

PUBLICATION DATE

March 29, 2023

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
FSHR agonist 1 T449 3.32x32 TM3 Van der Waals
FSHR agonist 1 T449 3.32x32 TM3 polar (hydrogen bond with backbone)
FSHR agonist 1 V450 3.33x33 TM3 Van der Waals
FSHR agonist 1 V450 3.33x33 TM3 hydrophobic
FSHR agonist 1 S453 3.36x36 TM3 polar (hydrogen bond)
FSHR agonist 1 E454 3.37x37 TM3 polar (charge-assisted hydrogen bond)
FSHR agonist 1 L518 45.51x51 ECL2 polar (hydrogen bond)
FSHR agonist 1 P519 45.52x52 ECL2 polar (hydrogen bond)
FSHR agonist 1 P519 45.52x52 ECL2 polar (hydrogen bond with backbone)
FSHR agonist 1 M520 ECL2 Van der Waals
FSHR agonist 1 M520 ECL2 polar (hydrogen bond with backbone)
FSHR agonist 1 I522 ECL2 Van der Waals
FSHR agonist 1 V531 5.40x40 TM5 Van der Waals
FSHR agonist 1 L534 5.43x43 TM5 Van der Waals
FSHR agonist 1 L535 5.44x44 TM5 Van der Waals
FSHR agonist 1 N538 5.47x47 TM5 polar (hydrogen bond)
FSHR agonist 1 I588 6.51x51 TM6 Van der Waals
FSHR agonist 1 I588 6.51x51 TM6 hydrophobic
FSHR agonist 1 F591 6.54x54 TM6 polar (hydrogen bond with backbone)
FSHR agonist 1 F591 6.54x54 TM6 Van der Waals
FSHR agonist 1 A592 6.55x55 TM6 polar (hydrogen bond)
FSHR agonist 1 A595 6.58x58 TM6 polar (hydrogen bond)
FSHR agonist 1 S596 6.59x59 TM6 polar (hydrogen bond)
FSHR agonist 1 P600 ECL3 Van der Waals
FSHR agonist 1 I602 ECL3 polar (hydrogen bond with backbone)
FSHR agonist 1 I602 ECL3 Van der Waals
FSHR agonist 1 T603 7.30x29 TM7 polar (hydrogen bond with backbone)
FSHR agonist 1 T603 7.30x29 TM7 Van der Waals
FSHR agonist 1 V604 7.31x30 TM7 Van der Waals
FSHR agonist 1 A607 7.34x33 TM7 polar (hydrogen bond with backbone)
FSHR agonist 1 A607 7.34x33 TM7 Van der Waals
FSHR agonist 1 L610 7.37x36 TM7 Van der Waals
FSHR agonist 1 L611 7.38x37 TM7 polar (hydrogen bond with backbone)
FSHR agonist 1 L611 7.38x37 TM7 Van der Waals
FSHR agonist 1 H615 7.42x41 TM7 polar (hydrogen bond)

Ligands

FSHR agonist 1

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Residue Diagrams

I N G T I A L I S I F W I L V R L I N Y 1 C N L A F A D L C I G I Y L L L I A S V 2 A T L T Y V S L E S A F V T F F G A A D 3 A A S V M V M G W I F A F A A A L F P I 4 Y C G C I V V F A L V N L V L L S M V Y 5 A M L I F T D F L C M A P I S F F A I S 6 F P N A C S N I P H F L V L L I K A K 7
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ICL1 Q Y K L T ICL1ECL1 S Q Y H N Y A I D W Q T ECL1ICL2 A M Q L D C K V ICL2ECL2 I S S Y M K V S I C L P M D I D ECL2ICL3 N P N I V ICL3ECL3 V P L I ECL3N-term M A L L L V S L L A F L S L G S G C H H R I C H C S N R V F L C Q E S K V T E I P S D L P R N A I E L R F V L T K L R V I Q K G A F S G F G D L E K I E I S Q N D V L E V I E A D V F S N L P K L H E I R I E K A N N L L Y I N P E A F Q N L P N L Q Y L L I S N T G I K H L P D V H K I H S L Q K V L L D I Q D N I N I H T I E R N S F V G L S F E S V I L W L N K N G I Q E I H N C A F N G T Q L D E L N L S D N N N L E E L P N D V F H G A S G P V I L D I S R T R I H S L P S Y G L E N L K K L R A R S T Y N L K K L P T L E K L V A L M E A S L T Y P S H C C A F A N W R R Q I S E L H P I C N K S I L R Q E V D Y M T Q A R G Q R S S L A E D N E S S Y S R G F D M T Y T E F D Y D L C N E V V D V T C S P K P D A F N P C E D I M G N-termC-term C Y E M Q A Q I Y R T E T S S T V H N T H P R N G H C S S A P R V T N G S T Y I L V P L S H L A Q N C-term Y N I L R V L I W F I S I L A I T G N I I V L V I L T T S V P R F L M C N L A F A D L C I G I Y L L L I A S V D I H T K G A G C D A A G F F T V F A S E L S V Y T L T A I T L E R W H T I T H Q L R H A A S V M V M G W I F A F A A A L F P I F G S P L S Q L Y V M S L L V L N V L A F V V I C G C Y I H I Y L T V R S S S S D T R I A K R M A M L I F T D F L C M A P I S F F A I S A S L K T V S K A K I L L V L F H P I N S C A N P F L Y A I F T K N F F I C G F R R D L L S K
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Residue Table


GPCRdb(A)
GPCRdb(A)
FSH receptor
TM3
3x32 3.32x32 T449
3x33 3.33x33 V450
3x36 3.36x36 S453
3x37 3.37x37 E454
ECL2
45x51 45.51x51 L518
45x52 45.52x52 P519
TM5
5x40 5.40x40 V531
5x43 5.43x43 L534
5x44 5.44x44 L535
5x47 5.47x47 N538
TM6
6x51 6.51x51 I588
6x54 6.54x54 F591
6x55 6.55x55 A592
6x58 6.58x58 A595
6x59 6.59x59 S596
TM7
7x29 7.30x29 T603
7x30 7.31x30 V604
7x33 7.34x33 A607
7x36 7.37x36 L610
7x37 7.38x37 L611
7x41 7.42x41 H615