PDB
8I2G
Resolution
2.8 Å
Released
March 29, 2023
Receptor
FSH
Class
A
Species
Homo sapiens
Ligands
Follitropin (FSH) (chain Y)
Follitropin (FSH) (chain X)
Cpd-21f
Function
Agonist
Agonist
Allosteric agonist
Reference
10.1038/S41467-023-36170-3
Follitropin (FSH) (chain Y) Follitropin (FSH) (chain X) Cpd-21f

NGL is a WebGL based 3D viewer powered by MMTF.

Download PDB file
Download list in excel
Ligand Amino Acid Generic Number Segment Interaction Type
Follitropin (FSH) (chain Y) Q33 N-term polar (hydrogen bond)
Follitropin (FSH) (chain Y) R52 N-term Van der Waals
Follitropin (FSH) (chain Y) V54 N-term Van der Waals
Follitropin (FSH) (chain Y) L55 N-term Van der Waals
Follitropin (FSH) (chain Y) Q79 N-term Van der Waals
Follitropin (FSH) (chain X) Q79 N-term polar (hydrogen bond)
Follitropin (FSH) (chain X) Q79 N-term polar (hydrogen bond with backbone)
Follitropin (FSH) (chain X) Q79 N-term polar (hydrogen bond)
Follitropin (FSH) (chain X) D81 N-term Van der Waals
Follitropin (FSH) (chain X) H98 N-term Van der Waals
Follitropin (FSH) (chain X) E99 N-term Van der Waals
Follitropin (FSH) (chain Y) R101 N-term Van der Waals
Follitropin (FSH) (chain X) R101 N-term Van der Waals
Follitropin (FSH) (chain Y) E103 N-term polar (charge-assisted hydrogen bond)
Follitropin (FSH) (chain X) K104 N-term polar (charge-assisted hydrogen bond)
Follitropin (FSH) (chain Y) K104 N-term polar (charge-assisted hydrogen bond)
Follitropin (FSH) (chain X) K104 N-term polar (hydrogen bond with backbone)
Follitropin (FSH) (chain X) A105 N-term Van der Waals
Follitropin (FSH) (chain X) N106 N-term polar (hydrogen bond)
Follitropin (FSH) (chain X) N106 N-term polar (hydrogen bond with backbone)
Follitropin (FSH) (chain X) Y124 N-term polar (hydrogen bond)
Follitropin (FSH) (chain X) N129 N-term polar (hydrogen bond)
Follitropin (FSH) (chain X) T130 N-term Van der Waals
Follitropin (FSH) (chain X) T130 N-term polar (hydrogen bond with backbone)
Follitropin (FSH) (chain X) G131 N-term Van der Waals
Follitropin (FSH) (chain X) G131 N-term polar (hydrogen bond with backbone)
Follitropin (FSH) (chain Y) K146 N-term Van der Waals
Follitropin (FSH) (chain X) L148 N-term Van der Waals
Follitropin (FSH) (chain X) D150 N-term polar (charge-assisted hydrogen bond)
Follitropin (FSH) (chain X) Q152 N-term polar (hydrogen bond)
Follitropin (FSH) (chain X) D153 N-term polar (charge-assisted hydrogen bond)
Follitropin (FSH) (chain X) D153 N-term polar (charge-charge)
Follitropin (FSH) (chain X) D153 N-term polar (hydrogen bond with backbone)
Follitropin (FSH) (chain X) I155 N-term Van der Waals
Follitropin (FSH) (chain X) N156 N-term polar (hydrogen bond)
Follitropin (FSH) (chain X) W176 N-term polar (hydrogen bond)
Follitropin (FSH) (chain Y) K179 N-term polar (charge-assisted hydrogen bond)
Follitropin (FSH) (chain Y) D196 N-term Van der Waals
Follitropin (FSH) (chain Y) V221 N-term hydrophobic
Follitropin (FSH) (chain Y) V221 N-term Van der Waals
Follitropin (FSH) (chain Y) I222 N-term polar (hydrogen bond)
Follitropin (FSH) (chain Y) K243 N-term polar (charge-assisted hydrogen bond)
Follitropin (FSH) (chain X) H289 N-term Van der Waals
Follitropin (FSH) (chain X) I291 N-term polar (hydrogen bond with backbone)
Follitropin (FSH) (chain X) I291 N-term polar (hydrogen bond)
Follitropin (FSH) (chain X) S295 N-term Van der Waals
Follitropin (FSH) (chain Y) T329 N-term Van der Waals
Follitropin (FSH) (chain Y) Y330 N-term polar (hydrogen bond with backbone)
Follitropin (FSH) (chain Y) Y330 N-term polar (hydrogen bond)
Follitropin (FSH) (chain Y) E332 N-term Van der Waals
Follitropin (FSH) (chain Y) F333 N-term Van der Waals
Follitropin (FSH) (chain X) Y335 N-term polar (hydrogen bond)
Follitropin (FSH) (chain X) Y335 N-term polar (hydrogen bond)
Follitropin (FSH) (chain Y) Y335 N-term polar (hydrogen bond)
Follitropin (FSH) (chain X) Y335 N-term polar (hydrogen bond with backbone)
Follitropin (FSH) (chain X) D336 N-term Van der Waals
Follitropin (FSH) (chain Y) L337 N-term polar (hydrogen bond)
Cpd-21f T449 3.32x32 TM3 polar (hydrogen bond with backbone)
Cpd-21f T449 3.32x32 TM3 Van der Waals
Cpd-21f V450 3.33x33 TM3 Van der Waals
Cpd-21f V450 3.33x33 TM3 hydrophobic
Cpd-21f S453 3.36x36 TM3 polar (hydrogen bond)
Cpd-21f E454 3.37x37 TM3 polar (charge-assisted hydrogen bond)
Cpd-21f L518 45.51x51 ECL2 polar (hydrogen bond)
Cpd-21f P519 45.52x52 ECL2 polar (hydrogen bond with backbone)
Cpd-21f P519 45.52x52 ECL2 polar (hydrogen bond)
Cpd-21f M520 ECL2 Van der Waals
Cpd-21f M520 ECL2 polar (hydrogen bond with backbone)
Cpd-21f I522 ECL2 Van der Waals
Cpd-21f V531 5.40x40 TM5 Van der Waals
Cpd-21f L534 5.43x43 TM5 Van der Waals
Cpd-21f L535 5.44x44 TM5 Van der Waals
Cpd-21f N538 5.47x47 TM5 polar (hydrogen bond)
Cpd-21f I588 6.51x51 TM6 hydrophobic
Cpd-21f I588 6.51x51 TM6 Van der Waals
Cpd-21f F591 6.54x54 TM6 polar (hydrogen bond with backbone)
Cpd-21f F591 6.54x54 TM6 Van der Waals
Cpd-21f A592 6.55x55 TM6 polar (hydrogen bond)
Cpd-21f A595 6.58x58 TM6 polar (hydrogen bond)
Cpd-21f S596 6.59x59 TM6 polar (hydrogen bond)
Cpd-21f P600 ECL3 Van der Waals
Cpd-21f I602 ECL3 polar (hydrogen bond with backbone)
Cpd-21f I602 ECL3 Van der Waals
Cpd-21f T603 7.30x29 TM7 polar (hydrogen bond with backbone)
Cpd-21f T603 7.30x29 TM7 Van der Waals
Cpd-21f V604 7.31x30 TM7 Van der Waals
Cpd-21f A607 7.34x33 TM7 polar (hydrogen bond with backbone)
Cpd-21f A607 7.34x33 TM7 Van der Waals
Cpd-21f L610 7.37x36 TM7 Van der Waals
Cpd-21f L611 7.38x37 TM7 polar (hydrogen bond with backbone)
Cpd-21f L611 7.38x37 TM7 Van der Waals
Cpd-21f H615 7.42x41 TM7 polar (hydrogen bond)

NGL is a WebGL based 3D viewer powered by MMTF.

Download PDB file

NGL is a WebGL based 3D viewer powered by MMTF.

Download PDB file

NGL is a WebGL based 3D viewer powered by MMTF.

Download PDB file

Snake plot — Download: PNG | SVG
ICL1 Q Y K L T ICL1ECL1 S Q Y H N Y A I D W Q T ECL1ICL2 A M Q L D C K V ICL2ECL2 I S S Y M K V S I C L P M D I D ECL2ICL3 N P N I V ICL3ECL3 V P L I ECL3N-term M A L L L V S L L A F L S L G S G C H H R I C H C S N R V F L C Q E S K V T E I P S D L P R N A I E L R F V L T K L R V I Q K G A F S G F G D L E K I E I S Q N D V L E V I E A D V F S N L P K L H E I R I E K A N N L L Y I N P E A F Q N L P N L Q Y L L I S N T G I K H L P D V H K I H S L Q K V L L D I Q D N I N I H T I E R N S F V G L S F E S V I L W L N K N G I Q E I H N C A F N G T Q L D E L N L S D N N N L E E L P N D V F H G A S G P V I L D I S R T R I H S L P S Y G L E N L K K L R A R S T Y N L K K L P T L E K L V A L M E A S L T Y P S H C C A F A N W R R Q I S E L H P I C N K S I L R Q E V D Y M T Q A R G Q R S S L A E D N E S S Y S R G F D M T Y T E F D Y D L C N E V V D V T C S P K P D A F N P C E D I M G N-termC-term C Y E M Q A Q I Y R T E T S S T V H N T H P R N G H C S S A P R V T N G S T Y I L V P L S H L A Q N C-term Y N I L R V L I W F I S I L A I T G N I I V L V I L T T S V P R F L M C N L A F A D L C I G I Y L L L I A S V D I H T K G A G C D A A G F F T V F A S E L S V Y T L T A I T L E R W H T I T H Q L R H A A S V M V M G W I F A F A A A L F P I F G S P L S Q L Y V M S L L V L N V L A F V V I C G C Y I H I Y L T V R S S S S D T R I A K R M A M L I F T D F L C M A P I S F F A I S A S L K T V S K A K I L L V L F H P I N S C A N P F L Y A I F T K N F F I C G F R R D L L S K
Helix box plot — Download: PNG | SVG I N G T I A L I S I F W I L V R L I N Y 1 C N L A F A D L C I G I Y L L L I A S V 2 A T L T Y V S L E S A F V T F F G A A D 3 A A S V M V M G W I F A F A A A L F P I 4 Y C G C I V V F A L V N L V L L S M V Y 5 A M L I F T D F L C M A P I S F F A I S 6 F P N A C S N I P H F L V L L I K A K 7

GPCRdb(A)
GPCRdb(A)
FSH receptor
TM3
3x32 3.32x32 T449
3x33 3.33x33 V450
3x36 3.36x36 S453
3x37 3.37x37 E454
ECL2
45x51 45.51x51 L518
45x52 45.52x52 P519
TM5
5x40 5.40x40 V531
5x43 5.43x43 L534
5x44 5.44x44 L535
5x47 5.47x47 N538
TM6
6x51 6.51x51 I588
6x54 6.54x54 F591
6x55 6.55x55 A592
6x58 6.58x58 A595
6x59 6.59x59 S596
TM7
7x29 7.30x29 T603
7x30 7.31x30 V604
7x33 7.34x33 A607
7x36 7.37x36 L610
7x37 7.38x37 L611
7x41 7.42x41 H615