PDB
8I9L
Resolution
3.2 Å
Released
Oct. 18, 2023
Receptor
C3a
Class
A
Species
Homo sapiens
Ligand
C3a anaphylatoxin
Function
Agonist
Reference
10.1016/J.CELL.2023.09.020

NGL is a WebGL based 3D viewer powered by MMTF.

Download PDB file
Download list in excel
Ligand Amino Acid Generic Number Segment Interaction Type
C3a anaphylatoxin F77 2.59x59 TM2 hydrophobic
C3a anaphylatoxin Q85 2.67x67 TM2 Van der Waals
C3a anaphylatoxin Q85 2.67x67 TM2 polar (hydrogen bond with backbone)
C3a anaphylatoxin W88 23.50x50 ECL1 Van der Waals
C3a anaphylatoxin P99 3.29x29 TM3 hydrophobic
C3a anaphylatoxin P99 3.29x29 TM3 Van der Waals
C3a anaphylatoxin I102 3.32x32 TM3 Van der Waals
C3a anaphylatoxin I102 3.32x32 TM3 hydrophobic
C3a anaphylatoxin E162 ECL2 polar (charge-assisted hydrogen bond)
C3a anaphylatoxin F164 ECL2 Van der Waals
C3a anaphylatoxin F164 ECL2 hydrophobic
C3a anaphylatoxin T166 ECL2 Van der Waals
C3a anaphylatoxin T166 ECL2 polar (hydrogen bond with backbone)
C3a anaphylatoxin R171 ECL2 Van der Waals
C3a anaphylatoxin Y174 45.52x52 ECL2 polar (hydrogen bond)
C3a anaphylatoxin Y174 45.52x52 ECL2 Van der Waals
C3a anaphylatoxin R340 5.42x43 TM5 polar (charge-assisted hydrogen bond)
C3a anaphylatoxin Y393 6.51x51 TM6 Van der Waals
C3a anaphylatoxin Y393 6.51x51 TM6 polar (hydrogen bond with backbone)
C3a anaphylatoxin F396 6.54x54 TM6 Van der Waals
C3a anaphylatoxin G397 6.55x55 TM6 Van der Waals
C3a anaphylatoxin G397 6.55x55 TM6 polar (hydrogen bond with backbone)
C3a anaphylatoxin P405 ECL3 Van der Waals
C3a anaphylatoxin P405 ECL3 hydrophobic
C3a anaphylatoxin D417 7.35x34 TM7 polar (charge-assisted hydrogen bond)
C3a anaphylatoxin H418 7.36x35 TM7 Van der Waals
C3a anaphylatoxin I421 7.39x38 TM7 hydrophobic
C3a anaphylatoxin I421 7.39x38 TM7 Van der Waals

NGL is a WebGL based 3D viewer powered by MMTF.

Download PDB file

Snake plot — Download: PNG | SVG
ICL1 M Q R ICL1ECL1 G Q W P Y ECL1ICL2 P I W C Q N H R ICL2ECL2 E I F T T D N H N R C G Y K F G L S S S L D Y P D F Y G D P L E N R S L E N I V Q P P G E M N D R L D P S S F Q T N D H P W T V P T V F Q P Q T F Q R P S A D S L P R G S A R L T S Q N L Y S N V F K P A D V V S P K I P S G F P I E D H E T S P L D N S D A F L S T H L K L F P S A S S N S F Y E S E L P Q G F Q D Y Y N L G Q F T D D D Q ECL2ICL3 G R F A K S Q ICL3ECL3 D P E ECL3N-term M A S F S A E T N S T D L L S Q P W N N-termC-term S I Q G I L E A A F S E E L T R S T H C P S N N V I S E R N S T T V C-term E P P V I L S M V I L S L T F L L G L P G N G L V L W V A G L K T V N T I W F L H L T L A D L L C C L S L P F S L A H L A L Q G R F L C K L I P S I I V L N M F A S V F L L T A I S L D R C L V V F K N V G M A C S I C G C I W V V A F V M C I P V F V Y R V P T P L V A I T I T R L V V G F L L P S V I M I A C Y S F I V F R M Q R S K T F R V A V V V V A V F L V C W T P Y H I F G V L S L L T T P L G K T L M S W D H V C I A L A S A N S C F N P F L Y A L L G K D A R Q F R K K
Helix box plot — Download: PNG | SVG G N G P L G L L F T L S L I V M S L I V 1 L H L T L A D L L C C L S L P F S L A H 2 A T L L F V S A F M N L V I I S P I L K 3 A C S I C G C I W V V A F V M C I P V 4 Y C A I M I V S P L L F G V V L R T I T I 5 V V V V A V F L V C W T P Y H I F G V L 6 F P N F C S N A S A L A I C V H D W S 7

GPCRdb(A)
GPCRdb(A)
C3a receptor
TM2
2x59 2.59x59 F77
2x67 2.67x67 Q85
ECL1
23x50 23.50x50 W88
TM3
3x29 3.29x29 P99
3x32 3.32x32 I102
ECL2
45x52 45.52x52 Y174
TM5
5x43 5.42x43 R340
TM6
6x51 6.51x51 Y393
6x54 6.54x54 F396
6x55 6.55x55 G397
TM7
7x34 7.35x34 D417
7x35 7.36x35 H418
7x38 7.39x38 I421