PDB
8IA8
Resolution
2.9 Å
Released
May 24, 2023
Receptor
C3a
Class
A
Species
Homo sapiens
Ligand
E7
Function
Agonist
Reference
—

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Ligand Amino Acid Generic Number Segment Interaction Type
E7 P99 3.29x29 TM3 hydrophobic
E7 I102 3.32x32 TM3 hydrophobic
E7 F164 ECL2 hydrophobic
E7 R340 5.42x43 TM5 polar (charge-assisted hydrogen bond)
E7 Y393 6.51x51 TM6 Van der Waals
E7 Y393 6.51x51 TM6 polar (hydrogen bond with backbone)
E7 F396 6.54x54 TM6 polar (hydrogen bond with backbone)
E7 F396 6.54x54 TM6 Van der Waals
E7 G397 6.55x55 TM6 Van der Waals
E7 D417 7.35x34 TM7 polar (charge-assisted hydrogen bond)
E7 I421 7.39x38 TM7 hydrophobic
E7 I421 7.39x38 TM7 Van der Waals

E7

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Snake plot — Download: PNG | SVG
ICL1 M Q R ICL1ECL1 G Q W P Y ECL1ICL2 P I W C Q N H R ICL2ECL2 E I F T T D N H N R C G Y K F G L S S S L D Y P D F Y G D P L E N R S L E N I V Q P P G E M N D R L D P S S F Q T N D H P W T V P T V F Q P Q T F Q R P S A D S L P R G S A R L T S Q N L Y S N V F K P A D V V S P K I P S G F P I E D H E T S P L D N S D A F L S T H L K L F P S A S S N S F Y E S E L P Q G F Q D Y Y N L G Q F T D D D Q ECL2ICL3 G R F A K S Q ICL3ECL3 D P E ECL3N-term M A S F S A E T N S T D L L S Q P W N N-termC-term S I Q G I L E A A F S E E L T R S T H C P S N N V I S E R N S T T V C-term E P P V I L S M V I L S L T F L L G L P G N G L V L W V A G L K T V N T I W F L H L T L A D L L C C L S L P F S L A H L A L Q G R F L C K L I P S I I V L N M F A S V F L L T A I S L D R C L V V F K N V G M A C S I C G C I W V V A F V M C I P V F V Y R V P T P L V A I T I T R L V V G F L L P S V I M I A C Y S F I V F R M Q R S K T F R V A V V V V A V F L V C W T P Y H I F G V L S L L T T P L G K T L M S W D H V C I A L A S A N S C F N P F L Y A L L G K D A R Q F R K K
Helix box plot — Download: PNG | SVG G N G P L G L L F T L S L I V M S L I V 1 L H L T L A D L L C C L S L P F S L A H 2 A T L L F V S A F M N L V I I S P I L K 3 A C S I C G C I W V V A F V M C I P V 4 Y C A I M I V S P L L F G V V L R T I T I 5 V V V V A V F L V C W T P Y H I F G V L 6 F P N F C S N A S A L A I C V H D W S 7

GPCRdb(A)
GPCRdb(A)
C3a receptor
TM3
3x29 3.29x29 P99
3x32 3.32x32 I102
TM5
5x43 5.42x43 R340
TM6
6x51 6.51x51 Y393
6x54 6.54x54 F396
6x55 6.55x55 G397
TM7
7x34 7.35x34 D417
7x38 7.39x38 I421