PDB
8IBV
Resolution
3.2 Å
Released
April 12, 2023
Receptor
motilin
Class
A
Species
Homo sapiens
Ligand
Function
motilin (Human)
Agonist
Reference
10.1126/SCIADV.ADE9020

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Ligand Amino Acid Generic Number Segment Interaction Type
motilin (Human) C30 N-term Van der Waals
motilin (Human) P32 N-term Van der Waals
motilin (Human) F33 N-term hydrophobic
motilin (Human) S101 ECL1 polar (hydrogen bond)
motilin (Human) R102 ECL1 aromatic (pi-cation)
motilin (Human) L115 3.29x29 TM3 hydrophobic
motilin (Human) E119 3.33x33 TM3 polar (hydrogen bond)
motilin (Human) E119 3.33x33 TM3 polar (charge-charge)
motilin (Human) F173 4.60x61 TM4 Van der Waals
motilin (Human) D182 ECL2 polar (charge-charge)
motilin (Human) D182 ECL2 polar (hydrogen bond)
motilin (Human) R236 45.51x51 ECL2 polar (charge-charge)
motilin (Human) R236 45.51x51 ECL2 polar (hydrogen bond)
motilin (Human) F314 6.51x51 TM6 hydrophobic
motilin (Human) R318 6.55x55 TM6 hydrophobic
motilin (Human) R318 6.55x55 TM6 polar (hydrogen bond)
motilin (Human) Y321 6.58x58 TM6 hydrophobic
motilin (Human) T324 6.61x61 TM6 hydrophobic
motilin (Human) E325 ECL3 Van der Waals
motilin (Human) D326 ECL3 Van der Waals
motilin (Human) S327 7.25x24 TM7 Van der Waals
motilin (Human) M330 7.28x27 TM7 hydrophobic
motilin (Human) S333 7.31x30 TM7 Van der Waals
motilin (Human) Q334 7.32x31 TM7 hydrophobic
motilin (Human) N337 7.35x34 TM7 hydrophobic
motilin (Human) I338 7.36x35 TM7 hydrophobic
motilin (Human) L341 7.39x38 TM7 hydrophobic

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Snake plot — Download: PNG | SVG
ICL1 R D M R ICL1ECL1 R P W V F ECL1ICL2 P L R A R V L V ICL2ECL2 G V E Q D P G I S V V P G L N G T A R I A S S P L A S S P P L W L S R A P P P S P P S G P E T A E A A A L F S R E C R P S P A ECL2ICL3 R G P A A ICL3ECL3 E D ECL3N-term M G S P W N G S D G P E G A R E P P W P A L P P C D E R R C S P F N-termC-term S R P R G F H R S R D T A G E V A G D T G G D T V G Y T E T S A N V K T M G C-term P L G A L V P V T A V C L C L F V V G V S G N V V T V M L I G R Y T T T N L Y L G S M A V S D L L I L L G L P F D L Y R L W R S G P L L C R L S L Y V G E G C T Y A T L L H M T A L S V E R Y L A I C R T R R R V R A L I A V L W A V A L L S A G P F L F L V Q L G A L R V M L W V T T A Y F F L P F L C L S I L Y G L I G R E L W S S R R P L S G R E R G H R Q T V R V L L V V V L A F I I C W L P F H V G R I I Y I N T S R M M Y F S Q Y F N I V A L Q L F Y L S A S I N P I L Y N L I S K K A F K R K Y R A A L L L A
Helix box plot — Download: PNG | SVG V N G S V G V V F L C L C V A T V P V L 1 G S M A V S D L L I L L G L P F D L Y R 2 A T M H L L T A Y T C G E G V Y L S L R 3 V R A L I A V L W A V A L L S A G P F 4 Y L I S L C L F P L F F Y A T T V W L M V 5 L V V V L A F I I C W L P F H V G R I I 6 I P N I S A S L Y F L Q L A V I N F Y 7

GPCRdb(A)
GPCRdb(A)
motilin receptor
TM3
3x29 3.29x29 L115
3x33 3.33x33 E119
TM4
4x61 4.60x61 F173
ECL2
45x51 45.51x51 R236
TM6
6x51 6.51x51 F314
6x55 6.55x55 R318
6x58 6.58x58 Y321
6x61 6.61x61 T324
TM7
7x24 7.25x24 S327
7x27 7.28x27 M330
7x30 7.31x30 S333
7x31 7.32x31 Q334
7x34 7.35x34 N337
7x35 7.36x35 I338
7x38 7.39x38 L341