PDB
8ID3
Resolution
3.1 Å
Released
March 15, 2023
Receptor
FFA4
Class
A
Species
Homo sapiens
Ligand
Function
9-Hydroxyoctadecanoic acid
Agonist
Reference
10.1126/SCIENCE.ADD6220

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Ligand Amino Acid Generic Number Segment Interaction Type
9-Hydroxyoctadecanoic acid F27 N-term hydrophobic
9-Hydroxyoctadecanoic acid F88 2.53x53 TM2 hydrophobic
9-Hydroxyoctadecanoic acid F115 3.29x29 TM3 Van der Waals
9-Hydroxyoctadecanoic acid M118 3.32x32 TM3 hydrophobic
9-Hydroxyoctadecanoic acid T119 3.33x33 TM3 polar (hydrogen bond)
9-Hydroxyoctadecanoic acid G122 3.36x36 TM3 Van der Waals
9-Hydroxyoctadecanoic acid I126 3.40x40 TM3 hydrophobic
9-Hydroxyoctadecanoic acid L173 4.60x61 TM4 hydrophobic
9-Hydroxyoctadecanoic acid L196 45.52x52 ECL2 Van der Waals
9-Hydroxyoctadecanoic acid W198 ECL2 Van der Waals
9-Hydroxyoctadecanoic acid D208 5.39x40 TM5 polar (hydrogen bond)
9-Hydroxyoctadecanoic acid F211 5.42x43 TM5 hydrophobic
9-Hydroxyoctadecanoic acid W277 6.48x48 TM6 hydrophobic
9-Hydroxyoctadecanoic acid I280 6.51x51 TM6 hydrophobic
9-Hydroxyoctadecanoic acid I281 6.52x52 TM6 hydrophobic
9-Hydroxyoctadecanoic acid I284 6.55x55 TM6 hydrophobic
9-Hydroxyoctadecanoic acid I287 6.58x58 TM6 Van der Waals
9-Hydroxyoctadecanoic acid L288 6.59x59 TM6 Van der Waals
9-Hydroxyoctadecanoic acid F303 7.35x34 TM7 hydrophobic

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ICL1 R R R G A T ICL1ECL1 E A W L L ECL1ICL2 L Q R G V R G P ICL2ECL2 R V V P Q R L P G A D Q E I S I C T L I W P ECL2ICL3 A Y ICL3ECL3 D L V I ECL3N-term M S P E C A R A A G D A P L R S L E Q A N R T R F P F F S D V K G D N-termC-term P E K G A I L T D T S V K R N D L S I I S G C-term H R L V L A A V E T T V L V L I F A V S L L G N V C A L V L V A R R A C L V L N L F C A D L L F I S A I P L V L A V R W T G P V A C H L L F Y V M T L S G S V T I L T L A A V S L E R M V C I V H G R R A R A V L L A L I W G Y S A V A A L P L C V F F T I P G E I S W D V S F V T L N F L V P G L V I V I S Y S K I L Q I T K A S R K R L T V S L S E S H Q I R V S Q Q D F R L F R T L F L L M V S F F I M W S P I I I T I L L I L I Q N F K Q W P S L F F W V V A F T F A N S A L N P I L Y N M T L C R K I F F N E W K C C F W
Helix box plot — Download: PNG | SVG V N G L L S V A F I L V L V T T E V A A 1 L N L F C A D L L F I S A I P L V L A V 2 A A L T L I T V S G S L T M V Y F L L H 3 R A V L L A L I W G Y S A V A A L P L 4 Y S I V I V L G P V L F N L T V F S V D W 5 L F L L M V S F I F M W S P I I I T I L L 6 I P N L A S N A F T F A V V W F F L S 7

GPCRdb(A)
GPCRdb(A)
FFA4 receptor
TM2
2x53 2.53x53 F88
TM3
3x29 3.29x29 F115
3x32 3.32x32 M118
3x33 3.33x33 T119
3x36 3.36x36 G122
3x40 3.40x40 I126
TM4
4x61 4.60x61 L173
ECL2
45x52 45.52x52 L196
TM5
5x40 5.39x40 D208
5x43 5.42x43 F211
TM6
6x48 6.48x48 W277
6x51 6.51x51 I280
6x52 6.52x52 I281
6x55 6.55x55 I284
6x58 6.58x58 I287
6x59 6.59x59 L288
TM7
7x34 7.35x34 F303