PDB
8IEB
Resolution
3.0 Å
Released
Feb. 14, 2024
Receptor
GPR156
Class
C
Species
Homo sapiens
Ligand
PC 34:1
Function
Agonist
Reference
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Ligand Amino Acid Generic Number Segment Interaction Type
PC 34:1 L124 3.33x33 TM3 hydrophobic
PC 34:1 L127 3.36x36 TM3 hydrophobic
PC 34:1 W183 4.50x50 TM4 hydrophobic
PC 34:1 F215 ECL2 hydrophobic
PC 34:1 A217 45.51x51 ECL2 hydrophobic
PC 34:1 S218 45.52x52 ECL2 polar (hydrogen bond)
PC 34:1 S218 45.52x52 ECL2 Van der Waals
PC 34:1 S221 5.36x36 TM5 Van der Waals
PC 34:1 W224 5.39x39 TM5 hydrophobic
PC 34:1 W224 5.39x39 TM5 Van der Waals
PC 34:1 I225 5.40x40 TM5 hydrophobic
PC 34:1 I225 5.40x40 TM5 Van der Waals
PC 34:1 W229 5.44x44 TM5 hydrophobic
PC 34:1 W229 5.44x44 TM5 Van der Waals
PC 34:1 K232 5.47x47 TM5 Van der Waals
PC 34:1 L267 6.45x45 TM6 hydrophobic
PC 34:1 L267 6.45x45 TM6 Van der Waals
PC 34:1 A271 6.49x49 TM6 hydrophobic
PC 34:1 L274 6.52x52 TM6 Van der Waals
PC 34:1 L274 6.52x52 TM6 hydrophobic
PC 34:1 F275 6.53x53 TM6 hydrophobic
PC 34:1 F275 6.53x53 TM6 Van der Waals
PC 34:1 T278 6.56x56 TM6 Van der Waals
PC 34:1 R279 6.57x57 TM6 polar (charge-assisted hydrogen bond)
PC 34:1 C299 7.39x40 TM7 hydrophobic
PC 34:1 C299 7.39x40 TM7 Van der Waals
PC 34:1 T300 7.40x41 TM7 Van der Waals

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ICL1 N R K R I V K M S ICL1ECL1 Q D V L ECL1ICL2 Q R V P D K R V I I ICL2ECL2 P I Q C L Q I L S V S M T V T G K D V S C T S T S T H F C A S R ECL2ICL3 S S P P V N Q ICL3ECL3 S ECL3N-term M E P E I N C S E L C D S F P G Q E L D R R P L H D L C K T T I T S S H H S S K T I S S L N-termC-term Y F S T P N K S F H T Q Y G E E E N C H P R G E K S S M E R L L T E K N A V I E S L Q E Q V N N A K E K I V R L M S A E C T Y D L P E G A A P P A S S P N K D V Q A V A S V H T L A A A Q G P S G H L S D F Q N D P G M A A R D S Q C T S G P S S Y A Q S L E G P G K D S S F S P G K E E K I S D S K D F S D H L D S G C S Q K P W T E Q S L G P E R G D Q V P M N P S Q S L L P E R G G S D P Q R Q R H L E N S E E P P E R R S R V S S V I R E K L Q E V L Q D L G L G P E A S L S T A P S C H Q Q T W K N S A A F S P Q K M P L S K E L G F S P Y M V R R R R A A Q R A R S H F P G S A P S S V G H R A N R T V P G A H S R L H V Q N G D S P S L A P Q T T D S R V R R P S S R K P S L P S D P Q D R P G T L E G S K Q S Q T E P E G A R G S K A A F L R Q P S G S G R A P S P A A P C L S K A S P D L P E Q W Q L W P P V P S G C A S L S S Q H S Y F D T E S S S S D E F F C R C H R P Y C E I C F Q S S S D S S D S G T S D T D P E P T G G L A S W E K L W A R S K P I V N F K D D L K P T L V C-term S P V L L G I V W T F L S C G L L L I L F F L A F T I H C S P N L N I V T L L G S C L T Y S S A Y L F G I V G S S M E T L I Q T R L S M L C I G T S L V F G P I L G K S W R L Y K V F T K D L Q L L G L V A A L L M A D V I L L M T W V L T D Y S D V W I A L I W G C K G L L L L Y G A Y L A G L T G H V S L T I M V G V N L L V L A A G L L F V V T R Y L H W P N L V F G L T S G G I F V C T T T I N C F I F I P Q L K Q W K A F E E E R R M N Q T I A K
Helix box plot — Download: PNG | SVG L I L L L G C S L F T W V I G L L V P S 1 I V T L L G S C L T Y S S A Y L F G I 2 G L I P G F V L S T G I C L M S L R T Q 3 L L G L V A A L L M A D V I L L M T W V 4 A L Y A G Y L L L L G K C G W I L A I W 5 V G V N L L V L A A G L L F V V T R Y L 6 C N I T T T C V F I G G S T L G F V L N 7

GPCRdb(A)
GPCRdb(C)
GPR156
TM3
3x29 3.33x33 L124
3x32 3.36x36 L127
TM4
4x60 4.50x50 W183
ECL2
45x51 45.51x51 A217
45x52 45.52x52 S218
TM5
5x36 5.36x36 S221
5x39 5.39x39 W224
5x40 5.40x40 I225
5x44 5.44x44 W229
5x47 5.47x47 K232
TM6
6x43 6.45x45 L267
6x47 6.49x49 A271
6x50 6.52x52 L274
6x51 6.53x53 F275
6x54 6.56x56 T278
6x55 6.57x57 R279
TM7
7x45 7.39x40 C299
7x46 7.40x41 T300