Structure information

HCA3 receptor

PROTEIN CLASS

Class A (Rhodopsin)

PDB CODE

8IHK

SPECIES

Homo sapiens

RESOLUTION

3.210

PREFERRED CHAIN

R

REFERENCE

10.1038/S41467-023-41650-7

PUBLICATION DATE

Aug. 30, 2023

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
(5S)-5-methyl-4-oxo-5-phenylfuran-2-carboxylic acid V83 2.60x60 TM2 hydrophobic
(5S)-5-methyl-4-oxo-5-phenylfuran-2-carboxylic acid Y86 2.63x63 TM2 hydrophobic
(5S)-5-methyl-4-oxo-5-phenylfuran-2-carboxylic acid W93 23.50x50 ECL1 hydrophobic
(5S)-5-methyl-4-oxo-5-phenylfuran-2-carboxylic acid V103 3.28x28 TM3 hydrophobic
(5S)-5-methyl-4-oxo-5-phenylfuran-2-carboxylic acid L104 3.29x29 TM3 hydrophobic
(5S)-5-methyl-4-oxo-5-phenylfuran-2-carboxylic acid F107 3.32x32 TM3 aromatic (face-to-edge)
(5S)-5-methyl-4-oxo-5-phenylfuran-2-carboxylic acid R111 3.36x36 TM3 polar (charge-assisted hydrogen bond)
(5S)-5-methyl-4-oxo-5-phenylfuran-2-carboxylic acid C177 45.50x50 ECL2 Van der Waals
(5S)-5-methyl-4-oxo-5-phenylfuran-2-carboxylic acid F180 ECL2 Van der Waals
(5S)-5-methyl-4-oxo-5-phenylfuran-2-carboxylic acid F277 7.36x35 TM7 Van der Waals
(5S)-5-methyl-4-oxo-5-phenylfuran-2-carboxylic acid L280 7.39x38 TM7 hydrophobic
(5S)-5-methyl-4-oxo-5-phenylfuran-2-carboxylic acid L280 7.39x38 TM7 Van der Waals
(5S)-5-methyl-4-oxo-5-phenylfuran-2-carboxylic acid Y284 7.43x42 TM7 polar (hydrogen bond)
(5S)-5-methyl-4-oxo-5-phenylfuran-2-carboxylic acid Y284 7.43x42 TM7 Van der Waals

Ligands

(5S)-5-methyl-4-oxo-5-phenylfuran-2-carboxylic acid

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Residue Diagrams

G N G L L G F I F E L G L V P P L V K A 1 F N L A V A D F L L I I C L P F V M D Y 2 V T L F I I S G Q R N M A F M F L V L R 3 A A I I S C L L W G I T V G L T V H L L 4 S C F L I I G L P L F F E L L F M A E H W 5 M V V A I V F V I C F L P S V V V R I H 6 V P D L M S N M Y T F S L T I F F A L 7
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ICL1 L K S W ICL1ECL1 R S D W K F ECL1ICL2 P H H A L N K I ICL2ECL2 L L I Q N G T A N V C I S F S I C H T F ECL2ICL3 Q M D R H A ICL3ECL3 G T Q N C E ECL3N-term M N R H H L Q D H F L E I D K K N C C V F R N-termC-term R C L Q R K I T G E P D N N R S T S V E L T G D P N K T R G A P E A L I A N S G E P W S P S Y L G P T S N N H S K K G H C H Q E P A S L E K Q L G C C I E C-term D D F I A K V L P P V L G L E F I F G L L G N G L A L W I F C F H K S S R I F L F N L A V A D F L L I I C L P F V M D Y Y V R G D I P C R L V L F M F A M N R Q G S I I F L T V V A V D R Y F R V V H S N W T A A I I S C L L W G I T V G L T V H L L K K K R W H E A M F L L E F F L P L G I I L F C S A R I I W S L R Q R K I K R A I T F I M V V A I V F V I C F L P S V V V R I H I F W L L H T S V Y R S V D L A F F I T L S F T Y M N S M L D P V V Y Y F S S P S F S T F P N F L I N
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Residue Table


GPCRdb(A)
GPCRdb(A)
HCA3 receptor
TM2
2x60 2.60x60 V83
2x63 2.63x63 Y86
ECL1
23x50 23.50x50 W93
TM3
3x28 3.28x28 V103
3x29 3.29x29 L104
3x32 3.32x32 F107
3x36 3.36x36 R111
ECL2
45x50 45.50x50 C177
TM7
7x35 7.36x35 F277
7x38 7.39x38 L280
7x42 7.43x42 Y284