PDB
8IHK
Resolution
3.2 Å
Released
Aug. 30, 2023
Receptor
HCA3
Class
A
Species
Homo sapiens
Ligand
Acifran
Function
Agonist
Reference
10.1038/S41467-023-41650-7

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Ligand Amino Acid Generic Number Segment Interaction Type
Acifran V83 2.60x60 TM2 hydrophobic
Acifran Y86 2.63x63 TM2 hydrophobic
Acifran W93 23.50x50 ECL1 hydrophobic
Acifran V103 3.28x28 TM3 hydrophobic
Acifran L104 3.29x29 TM3 hydrophobic
Acifran F107 3.32x32 TM3 aromatic (face-to-edge)
Acifran R111 3.36x36 TM3 polar (charge-assisted hydrogen bond)
Acifran C177 45.50x50 ECL2 Van der Waals
Acifran F180 ECL2 Van der Waals
Acifran F277 7.36x35 TM7 Van der Waals
Acifran L280 7.39x38 TM7 hydrophobic
Acifran L280 7.39x38 TM7 Van der Waals
Acifran Y284 7.43x42 TM7 polar (hydrogen bond)
Acifran Y284 7.43x42 TM7 Van der Waals

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Snake plot — Download: PNG | SVG
ICL1 L K S W ICL1ECL1 R S D W K F ECL1ICL2 P H H A L N K I ICL2ECL2 L L I Q N G T A N V C I S F S I C H T F ECL2ICL3 Q M D R H A ICL3ECL3 G T Q N C E ECL3N-term M N R H H L Q D H F L E I D K K N C C V F R N-termC-term R C L Q R K I T G E P D N N R S T S V E L T G D P N K T R G A P E A L I A N S G E P W S P S Y L G P T S N N H S K K G H C H Q E P A S L E K Q L G C C I E C-term D D F I A K V L P P V L G L E F I F G L L G N G L A L W I F C F H K S S R I F L F N L A V A D F L L I I C L P F V M D Y Y V R G D I P C R L V L F M F A M N R Q G S I I F L T V V A V D R Y F R V V H S N W T A A I I S C L L W G I T V G L T V H L L K K K R W H E A M F L L E F F L P L G I I L F C S A R I I W S L R Q R K I K R A I T F I M V V A I V F V I C F L P S V V V R I H I F W L L H T S V Y R S V D L A F F I T L S F T Y M N S M L D P V V Y Y F S S P S F S T F P N F L I N
Helix box plot — Download: PNG | SVG G N G L L G F I F E L G L V P P L V K A 1 F N L A V A D F L L I I C L P F V M D Y 2 V T L F I I S G Q R N M A F M F L V L R 3 A A I I S C L L W G I T V G L T V H L L 4 S C F L I I G L P L F F E L L F M A E H W 5 M V V A I V F V I C F L P S V V V R I H 6 V P D L M S N M Y T F S L T I F F A L 7

GPCRdb(A)
GPCRdb(A)
HCA3 receptor
TM2
2x60 2.60x60 V83
2x63 2.63x63 Y86
ECL1
23x50 23.50x50 W93
TM3
3x28 3.28x28 V103
3x29 3.29x29 L104
3x32 3.32x32 F107
3x36 3.36x36 R111
ECL2
45x50 45.50x50 C177
TM7
7x35 7.36x35 F277
7x38 7.39x38 L280
7x42 7.43x42 Y284