Structure information

HCA2 receptor

PROTEIN CLASS

Class A (Rhodopsin)

PDB CODE

8IJA

SPECIES

Homo sapiens

RESOLUTION

2.690

PREFERRED CHAIN

A

REFERENCE

10.1038/S41421-023-00610-7

PUBLICATION DATE

Jan. 3, 2024

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
nicotinic acid L83 2.60x60 TM2 hydrophobic
nicotinic acid L107 3.32x32 TM3 hydrophobic
nicotinic acid S179 45.52x52 ECL2 polar (hydrogen bond with backbone)
nicotinic acid S179 45.52x52 ECL2 polar (hydrogen bond)
nicotinic acid S179 45.52x52 ECL2 Van der Waals
nicotinic acid F180 ECL2 hydrophobic
nicotinic acid F180 ECL2 Van der Waals
nicotinic acid F277 7.36x35 TM7 Van der Waals
nicotinic acid F277 7.36x35 TM7 hydrophobic
nicotinic acid L280 7.39x38 TM7 Van der Waals
nicotinic acid L280 7.39x38 TM7 hydrophobic

Ligands

nicotinic acid

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Residue Diagrams

G N G L L G F I F E L G L V P P L V K V 1 F N L A V A D F L L I I C L P F L M D N 2 V T L F I I S G Q R N M A L M F L M L R 3 A A I I S C L L W G I T I G L T V H L L 4 S C F L I I G L P L F F E L L F M A E H W 5 M V V A I V F V I C F L P S V V V R I R 6 V P D L M S N M Y T F S L T I F F A L 7
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ICL1 L K S W ICL1ECL1 W D W K F ECL1ICL2 P H H A L N K I ICL2ECL2 M P I Q N G G A N L C S S F S I C H T F ECL2ICL3 M D R H A ICL3ECL3 G T Q N C E V ECL3N-term M N R H H L Q D H F L E I D K K N C C V F R D D N-termC-term Q R K M T G E P D N N R S T S V E L T G D P N K T R G A P E A L M A N S G E P W S P S Y L G P T S P C-term F I V K V L P P V L G L E F I F G L L G N G L A L W I F C F H K S S R I F L F N L A V A D F L L I I C L P F L M D N Y V R R G D I P C R L M L F M L A M N R Q G S I I F L T V V A V D R Y F R V V H S N R T A A I I S C L L W G I T I G L T V H L L K K K Q W H E A M F L L E F F L P L G I I L F C S A R I I W S L R Q R Q K I K R A I T F I M V V A I V F V I C F L P S V V V R I R I F W L L H T S Y R S V D L A F F I T L S F T Y M N S M L D P V V Y Y F S S P S F S T C L F P N F L I N R
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Residue Table


GPCRdb(A)
GPCRdb(A)
HCA2 receptor
TM2
2x60 2.60x60 L83
TM3
3x32 3.32x32 L107
ECL2
45x52 45.52x52 S179
TM7
7x35 7.36x35 F277
7x38 7.39x38 L280