Structure information

MC3 receptor

PROTEIN CLASS

Class A (Rhodopsin)

PDB CODE

8IOC

SPECIES

Homo sapiens

RESOLUTION

2.860

PREFERRED CHAIN

R

REFERENCE

10.1107/S0907444909042073

PUBLICATION DATE

Sept. 20, 2023

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
γ-MSH Q37 N-term polar (hydrogen bond)
γ-MSH Q37 N-term Van der Waals
γ-MSH F45 1.39x39 TM1 Van der Waals
γ-MSH F45 1.39x39 TM1 hydrophobic
γ-MSH E94 2.60x60 TM2 polar (charge-assisted hydrogen bond)
γ-MSH T95 2.61x61 TM2 Van der Waals
γ-MSH T95 2.61x61 TM2 polar (hydrogen bond)
γ-MSH I98 2.64x64 TM2 hydrophobic
γ-MSH I98 2.64x64 TM2 Van der Waals
γ-MSH D110 3.18x18 TM3 polar (charge-assisted hydrogen bond)
γ-MSH I113 3.21x21 TM3 Van der Waals
γ-MSH I113 3.21x21 TM3 hydrophobic
γ-MSH Q114 3.22x22 TM3 Van der Waals
γ-MSH D117 3.25x25 TM3 Van der Waals
γ-MSH N118 3.26x26 TM3 Van der Waals
γ-MSH N118 3.26x26 TM3 polar (hydrogen bond)
γ-MSH D121 3.29x29 TM3 polar (charge-assisted hydrogen bond)
γ-MSH I124 3.32x32 TM3 Van der Waals
γ-MSH I124 3.32x32 TM3 hydrophobic
γ-MSH C125 3.33x33 TM3 hydrophobic
γ-MSH C125 3.33x33 TM3 Van der Waals
γ-MSH L128 3.36x36 TM3 Van der Waals
γ-MSH F179 4.60x60 TM4 Van der Waals
γ-MSH I180 4.61x61 TM4 hydrophobic
γ-MSH I180 4.61x61 TM4 Van der Waals
γ-MSH S183 ECL2 polar (hydrogen bond)
γ-MSH E184 ECL2 Van der Waals
γ-MSH K186 5.37x37 TM5 Van der Waals
γ-MSH I189 5.40x40 TM5 Van der Waals
γ-MSH I189 5.40x40 TM5 hydrophobic
γ-MSH F258 6.51x51 TM6 hydrophobic
γ-MSH F258 6.51x51 TM6 Van der Waals
γ-MSH H261 6.54x54 TM6 Van der Waals
γ-MSH H261 6.54x54 TM6 polar (hydrogen bond)
γ-MSH L262 6.55x55 TM6 Van der Waals
γ-MSH I265 6.58x58 TM6 hydrophobic
γ-MSH I265 6.58x58 TM6 Van der Waals
γ-MSH I266 6.59x59 TM6 hydrophobic
γ-MSH F281 7.35x34 TM7 hydrophobic
γ-MSH F281 7.35x34 TM7 Van der Waals
γ-MSH L285 7.39x38 TM7 hydrophobic
γ-MSH L285 7.39x38 TM7 Van der Waals

Ligands

γ-MSH

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Residue Diagrams

I N E L L S V I G L S L F V E P K 1 C S L A V A D M L V S V S N A L E T I M 2 A L L N C I S A V L S I C I M S D F I N 3 A L T L I V A I W V C C G V C G V V F I 4 Y L T G M L L M M A F F M T I L C V I V 5 T I L L G V F I F C W A P F F L H L V L 6 L P D I V S N C M I L V L Y T N F H 7
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ICL1 G N L H ICL1ECL1 D Y L T F ECL1ICL2 A L R Y H S I M ICL2ECL2 E ECL2ICL3 A L P P A D G V A P Q ICL3ECL3 P T N P Y C I C Y T A ECL3N-term M N A S C C L P S V Q P T L P N G S E H L Q A P F F S N Q S S S A F C E Q V F I N-termC-term N G M N L G C-term K P E V F L S L G I V S L L E N I L V I L A V V R N S P M Y F F L C S L A V A D M L V S V S N A L E T I M I A I V H S E D Q F I Q H M D N I F D S M I C I S L V A S I C N L L A I A V D R Y V T I F Y T V R K A L T L I V A I W V C C G V C G V V F I V Y S S K M V I V C L I T M F F A M M L L M G T L Y V H M F L F A R L H V K R I A Q H S C M K G A V T I T I L L G V F I F C W A P F F L H L V L I I T C H F N T Y L V L I M C N S V I D P L I Y A F R S L E F R E C L R N T I L C G
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Residue Table


GPCRdb(A)
GPCRdb(A)
MC3 receptor
TM1
1x39 1.39x39 F45
TM2
2x60 2.60x60 E94
2x61 2.61x61 T95
2x64 2.64x64 I98
TM3
3x18 3.18x18 D110
3x21 3.21x21 I113
3x22 3.22x22 Q114
3x25 3.25x25 D117
3x26 3.26x26 N118
3x29 3.29x29 D121
3x32 3.32x32 I124
3x33 3.33x33 C125
3x36 3.36x36 L128
TM4
4x60 4.60x60 F179
4x61 4.61x61 I180
TM5
5x37 5.37x37 K186
5x40 5.40x40 I189
TM6
6x51 6.51x51 F258
6x54 6.54x54 H261
6x55 6.55x55 L262
6x58 6.58x58 I265
6x59 6.59x59 I266
TM7
7x34 7.35x34 F281
7x38 7.39x38 L285