PDB
8IOC
Resolution
2.9 Å
Released
Sept. 20, 2023
Receptor
MC3
Class
A
Species
Homo sapiens
Ligands
Function
γ-MSH (Human)
Agonist
Calcium
PAM
Reference
10.1038/s41421-023-00586-4
γ-MSH (Human) Calcium

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Ligand Amino Acid Generic Number Segment Interaction Type
γ-MSH (Human) Q37 N-term Van der Waals
γ-MSH (Human) F45 1.39x39 TM1 aromatic (face-to-face)
γ-MSH (Human) E94 2.60x60 TM2 polar (hydrogen bond)
Calcium E94 2.60x60 TM2 metal coordination
γ-MSH (Human) T95 2.61x61 TM2 polar (hydrogen bond)
γ-MSH (Human) M97 2.63x63 TM2 Van der Waals
γ-MSH (Human) I98 2.64x64 TM2 hydrophobic
γ-MSH (Human) D110 3.18x18 TM3 polar (charge-charge)
γ-MSH (Human) I113 3.21x21 TM3 hydrophobic
γ-MSH (Human) Q114 3.22x22 TM3 hydrophobic
Calcium D117 3.25x25 TM3 polar (charge-charge)
γ-MSH (Human) D117 3.25x25 TM3 Van der Waals
γ-MSH (Human) N118 3.26x26 TM3 polar (hydrogen bond)
Calcium D121 3.29x29 TM3 metal coordination
γ-MSH (Human) D121 3.29x29 TM3 polar (hydrogen bond)
γ-MSH (Human) D121 3.29x29 TM3 polar (charge-charge)
γ-MSH (Human) I124 3.32x32 TM3 hydrophobic
γ-MSH (Human) C125 3.33x33 TM3 Van der Waals
γ-MSH (Human) L128 3.36x36 TM3 hydrophobic
γ-MSH (Human) F179 4.60x60 TM4 Van der Waals
γ-MSH (Human) I180 4.61x61 TM4 hydrophobic
γ-MSH (Human) S183 ECL2 polar (hydrogen bond)
γ-MSH (Human) E184 ECL2 polar (charge-charge)
γ-MSH (Human) S185 ECL2 Van der Waals
γ-MSH (Human) K186 5.37x37 TM5 Van der Waals
γ-MSH (Human) V188 5.39x39 TM5 Van der Waals
γ-MSH (Human) I189 5.40x40 TM5 hydrophobic
γ-MSH (Human) F258 6.51x51 TM6 hydrophobic
γ-MSH (Human) H261 6.54x54 TM6 polar (hydrogen bond)
γ-MSH (Human) L262 6.55x55 TM6 hydrophobic
γ-MSH (Human) I265 6.58x58 TM6 hydrophobic
γ-MSH (Human) I266 6.59x59 TM6 Van der Waals
γ-MSH (Human) T278 ECL3 Van der Waals
γ-MSH (Human) F281 7.35x34 TM7 hydrophobic
γ-MSH (Human) L285 7.39x38 TM7 hydrophobic

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Snake plot — Download: PNG | SVG
ICL1 G N L H ICL1ECL1 D Y L T F ECL1ICL2 A L R Y H S I M ICL2ECL2 E ECL2ICL3 A L P P A D G V A P Q ICL3ECL3 P T N P Y C I C Y T A ECL3N-term M N A S C C L P S V Q P T L P N G S E H L Q A P F F S N Q S S S A F C E Q V F I N-termC-term N G M N L G C-term K P E V F L S L G I V S L L E N I L V I L A V V R N S P M Y F F L C S L A V A D M L V S V S N A L E T I M I A I V H S E D Q F I Q H M D N I F D S M I C I S L V A S I C N L L A I A V D R Y V T I F Y T V R K A L T L I V A I W V C C G V C G V V F I V Y S S K M V I V C L I T M F F A M M L L M G T L Y V H M F L F A R L H V K R I A Q H S C M K G A V T I T I L L G V F I F C W A P F F L H L V L I I T C H F N T Y L V L I M C N S V I D P L I Y A F R S L E F R E C L R N T I L C G
Helix box plot — Download: PNG | SVG I N E L L S V I G L S L F V E P K 1 C S L A V A D M L V S V S N A L E T I M 2 A L L N C I S A V L S I C I M S D F I N 3 A L T L I V A I W V C C G V C G V V F I 4 Y L T G M L L M M A F F M T I L C V I V 5 T I L L G V F I F C W A P F F L H L V L 6 L P D I V S N C M I L V L Y T N F H 7

GPCRdb(A)
GPCRdb(A)
MC3 receptor
TM1
1x39 1.39x39 F45
TM2
2x60 2.60x60 E94
2x61 2.61x61 T95
2x63 2.63x63 M97
2x64 2.64x64 I98
TM3
3x18 3.18x18 D110
3x21 3.21x21 I113
3x22 3.22x22 Q114
3x25 3.25x25 D117
3x26 3.26x26 N118
3x29 3.29x29 D121
3x32 3.32x32 I124
3x33 3.33x33 C125
3x36 3.36x36 L128
TM4
4x60 4.60x60 F179
4x61 4.61x61 I180
TM5
5x37 5.37x37 K186
5x39 5.39x39 V188
5x40 5.40x40 I189
TM6
6x51 6.51x51 F258
6x54 6.54x54 H261
6x55 6.55x55 L262
6x58 6.58x58 I265
6x59 6.59x59 I266
TM7
7x34 7.35x34 F281
7x38 7.39x38 L285