Structure information

FP receptor

PROTEIN CLASS

Class A (Rhodopsin)

PDB CODE

8IQ4

SPECIES

Homo sapiens

RESOLUTION

2.700

PREFERRED CHAIN

R

REFERENCE

10.1038/S41467-023-43922-8

PUBLICATION DATE

Jan. 31, 2024

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
Carboprost S33 1.39x39 TM1 polar (hydrogen bond)
Carboprost F36 1.42x42 TM1 Van der Waals
Carboprost M37 1.43x43 TM1 Van der Waals
Carboprost H81 2.54x54 TM2 polar (hydrogen bond)
Carboprost N84 2.57x57 TM2 Van der Waals
Carboprost G85 2.58x58 TM2 Van der Waals
Carboprost A88 2.61x61 TM2 Van der Waals
Carboprost A88 2.61x61 TM2 hydrophobic
Carboprost Y92 2.65x65 TM2 polar (hydrogen bond)
Carboprost F111 3.28x28 TM3 hydrophobic
Carboprost F111 3.28x28 TM3 Van der Waals
Carboprost M115 3.32x32 TM3 hydrophobic
Carboprost M115 3.32x32 TM3 Van der Waals
Carboprost S118 3.35x35 TM3 Van der Waals
Carboprost G119 3.36x36 TM3 Van der Waals
Carboprost T184 ECL2 polar (hydrogen bond)
Carboprost W185 ECL2 Van der Waals
Carboprost W185 ECL2 hydrophobic
Carboprost L287 7.36x35 TM7 Van der Waals
Carboprost L290 7.39x38 TM7 hydrophobic
Carboprost L290 7.39x38 TM7 Van der Waals
Carboprost R291 7.40x39 TM7 polar (charge-assisted hydrogen bond)
Carboprost T294 7.43x42 TM7 Van der Waals
Carboprost Q297 7.46x46 TM7 Van der Waals

Ligands

Carboprost

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Residue Diagrams

S N S L I G V T M F I V S F F V 1 S G L V I T D F F G H L I N G A I A V F 2 V S G L L L P C L G S F V M C I G F I S 3 V K M M L S G V C L F A V F I A L L P I 4 I A N C L L S V G L A L L G L F S F L L 5 L A I M C V S C I C W S P F L V T M A N 6 W P D L I Q N W T A M R L A F L T T E 7
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ICL1 K S K ICL1ECL1 K E W I R F D Q S ECL1ICL2 P I F H S T K I ICL2ECL2 H R D Y K I Q A S R T W C F Y N T E D I K ECL2ICL3 Q H R Q G ICL3ECL3 G N H S L E ECL3N-term M S M N N S K Q L V S P A A A L L S N T T C Q T E N R L S N-termC-term I S L H I W E L S S I K N S L K V A A I S E S P V A E K S A S T C-term V F F S V I F M T V G I L S N S L A I A I L M K A Y Q R F R Q A S F L L L A S G L V I T D F F G H L I N G A I A V F V Y A S D N V L C S I F G I C M V F S G L C P L L L G S V M A I E R C I G V T K T S K H V K M M L S G V C L F A V F I A L L P I L G D W E D R F Y L L L F S F L G L L A L G V S L L C N A I T G I T L L R V K F K S Q R S H H L E M V I Q L L A I M C V S C I C W S P F L V T M A N I G I N T C E T T L F A L R M A T W N Q I L D P W V Y I L L R K A L Y K C C G V L K N L A S Q V H V
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Residue Table


GPCRdb(A)
GPCRdb(A)
FP receptor
TM1
1x39 1.39x39 S33
1x42 1.42x42 F36
1x43 1.43x43 M37
TM2
2x54 2.54x54 H81
2x57 2.57x57 N84
2x58 2.58x58 G85
2x61 2.61x61 A88
2x65 2.65x65 Y92
TM3
3x28 3.28x28 F111
3x32 3.32x32 M115
3x35 3.35x35 S118
3x36 3.36x36 G119
TM7
7x35 7.36x35 L287
7x38 7.39x38 L290
7x39 7.40x39 R291
7x42 7.43x42 T294
7x46 7.46x46 Q297