PDB
8ITF
Resolution
3.5 Å
Released
May 31, 2023
Receptor
TAAR9
Class
A
Species
Mus musculus
Ligand
Function
N,N-dimethylcyclohexanamine
Agonist
Reference
10.1038/S41586-023-06106-4

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Ligand Amino Acid Generic Number Segment Interaction Type
N,N-dimethylcyclohexanamine D112 3.32x32 TM3 polar (hydrogen bond)
N,N-dimethylcyclohexanamine D112 3.32x32 TM3 polar (charge-charge)
N,N-dimethylcyclohexanamine T113 3.33x33 TM3 Van der Waals
N,N-dimethylcyclohexanamine F117 3.37x37 TM3 hydrophobic
N,N-dimethylcyclohexanamine C202 5.43x43 TM5 Van der Waals
N,N-dimethylcyclohexanamine W271 6.48x48 TM6 Van der Waals
N,N-dimethylcyclohexanamine Y274 6.51x51 TM6 hydrophobic
N,N-dimethylcyclohexanamine Y274 6.51x51 TM6 aromatic (pi-cation)
N,N-dimethylcyclohexanamine V297 7.39x38 TM7 Van der Waals
N,N-dimethylcyclohexanamine V300 7.42x41 TM7 Van der Waals
N,N-dimethylcyclohexanamine Y301 7.43x42 TM7 Van der Waals

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Snake plot — Download: PNG | SVG
ICL1 K Q L H ICL1ECL1 C W Y F ECL1ICL2 P L T Y P T K F ICL2ECL2 A N E E G I E E L V V A L T C V G G C Q A P L ECL2ICL3 A S S E S Y ICL3ECL3 N F I T ECL3N-term M T S D F S P E P P M E L C Y E N V N G S C I K N-termC-term G K V F R A D S S T T N L F S E E A G A G C-term S S Y A P W P R A I L Y G V L G L G A L L A V F G N L L V I I A I L H F T P T N F L V A S L A C A D F L V G V T V M P F S T V R S V E S G E S Y C K F H T C F D T S F C F A S L F H L C C I S I D R Y I A V T D T V S V S G L C I A L S W F F S V T Y S F S I F Y T G N Q N W V L L C F L L F F L P T V V M V F L Y G R I F L V A K Y Q A R K I E G T A N Q A Q K E R V A K R E R K A A K T L G I A M A A F L V S W L P Y I I D A V I D A Y M P A Y V Y E I L V W C V Y Y N S A M N P L I Y A F F Y P W I K L F R K A I V S
Helix box plot — Download: PNG | SVG L N G F V A L L A G L G L V G Y L I A R 1 A S L A C A D F L V G T V V M P F S T V R 2 C C L H F L S A F C F S T D F C T H F K 3 S G L C I A L S W F F S V T Y S F S I F 4 Y L F V M V V T P L F F L L F C L L V W 5 G I A M A A F L V S W L P Y I I D A V I 6 L P N M A S N Y Y V C W V L I E Y V Y 7

GPCRdb(A)
GPCRdb(A)
TAAR9
TM3
3x32 3.32x32 D112
3x33 3.33x33 T113
3x37 3.37x37 F117
TM5
5x43 5.43x43 C202
TM6
6x48 6.48x48 W271
6x51 6.51x51 Y274
TM7
7x38 7.39x38 V297
7x41 7.42x41 V300
7x42 7.43x42 Y301