Structure information

FP receptor

PROTEIN CLASS

Class A (Rhodopsin)

PDB CODE

8IUM

SPECIES

Homo sapiens

RESOLUTION

3.140

PREFERRED CHAIN

R

REFERENCE

10.1038/S41467-023-38411-X

PUBLICATION DATE

July 12, 2023

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
tafluprost acid S33 1.39x39 TM1 Van der Waals
tafluprost acid S33 1.39x39 TM1 polar (hydrogen bond)
tafluprost acid F36 1.42x42 TM1 Van der Waals
tafluprost acid M37 1.43x43 TM1 Van der Waals
tafluprost acid M37 1.43x43 TM1 hydrophobic
tafluprost acid H81 2.54x54 TM2 polar (hydrogen bond)
tafluprost acid H81 2.54x54 TM2 polar (hydrogen bond)
tafluprost acid N84 2.57x57 TM2 polar (hydrogen bond)
tafluprost acid Y92 2.65x65 TM2 Van der Waals
tafluprost acid Y92 2.65x65 TM2 polar (hydrogen bond)
tafluprost acid M115 3.32x32 TM3 hydrophobic
tafluprost acid M115 3.32x32 TM3 Van der Waals
tafluprost acid S118 3.35x35 TM3 polar (hydrogen bond)
tafluprost acid G119 3.36x36 TM3 Van der Waals
tafluprost acid T184 ECL2 Van der Waals
tafluprost acid T184 ECL2 polar (hydrogen bond)
tafluprost acid F205 5.41x41 TM5 hydrophobic
tafluprost acid F265 6.51x51 TM6 aromatic (face-to-edge)
tafluprost acid F265 6.51x51 TM6 Van der Waals
tafluprost acid L287 7.36x35 TM7 Van der Waals
tafluprost acid L290 7.39x38 TM7 hydrophobic
tafluprost acid L290 7.39x38 TM7 Van der Waals
tafluprost acid R291 7.40x39 TM7 polar (charge-assisted hydrogen bond)
tafluprost acid A293 7.42x41 TM7 Van der Waals
tafluprost acid T294 7.43x42 TM7 Van der Waals
tafluprost acid Q297 7.46x46 TM7 polar (hydrogen bond)
tafluprost acid Q297 7.46x46 TM7 polar (hydrogen bond)

Ligands

tafluprost acid

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Residue Diagrams

S N S L I G V T M F I V S F F V 1 S G L V I T D F F G H L I N G A I A V F 2 V S G L L L P C L G S F V M C I G F I S 3 V K M M L S G V C L F A V F I A L L P I 4 I A N C L L S V G L A L L G L F S F L L 5 L A I M C V S C I C W S P F L V T M A N 6 W P D L I Q N W T A M R L A F L T T E 7
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ICL1 K S K ICL1ECL1 K E W I R F D Q S ECL1ICL2 P I F H S T K I ICL2ECL2 H R D Y K I Q A S R T W C F Y N T E D I K ECL2ICL3 Q H R Q G ICL3ECL3 G N H S L E ECL3N-term M S M N N S K Q L V S P A A A L L S N T T C Q T E N R L S N-termC-term I S L H I W E L S S I K N S L K V A A I S E S P V A E K S A S T C-term V F F S V I F M T V G I L S N S L A I A I L M K A Y Q R F R Q A S F L L L A S G L V I T D F F G H L I N G A I A V F V Y A S D N V L C S I F G I C M V F S G L C P L L L G S V M A I E R C I G V T K T S K H V K M M L S G V C L F A V F I A L L P I L G D W E D R F Y L L L F S F L G L L A L G V S L L C N A I T G I T L L R V K F K S Q R S H H L E M V I Q L L A I M C V S C I C W S P F L V T M A N I G I N T C E T T L F A L R M A T W N Q I L D P W V Y I L L R K A L Y K C C G V L K N L A S Q V H V
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Residue Table


GPCRdb(A)
GPCRdb(A)
FP receptor
TM1
1x39 1.39x39 S33
1x42 1.42x42 F36
1x43 1.43x43 M37
TM2
2x54 2.54x54 H81
2x57 2.57x57 N84
2x65 2.65x65 Y92
TM3
3x32 3.32x32 M115
3x35 3.35x35 S118
3x36 3.36x36 G119
TM5
5x41 5.41x41 F205
TM6
6x51 6.51x51 F265
TM7
7x35 7.36x35 L287
7x38 7.39x38 L290
7x39 7.40x39 R291
7x41 7.42x41 A293
7x42 7.43x42 T294
7x46 7.46x46 Q297