PDB
8IW4
Resolution
3.5 Å
Released
May 31, 2023
Receptor
TAAR9
Class
A
Species
Mus musculus
Ligand
SPERMIDINE
Function
Agonist
Reference
10.1038/S41586-023-06106-4

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Ligand Amino Acid Generic Number Segment Interaction Type
SPERMIDINE T109 3.29x29 TM3 Van der Waals
SPERMIDINE T109 3.29x29 TM3 polar (hydrogen bond)
SPERMIDINE D112 3.32x32 TM3 polar (charge-assisted hydrogen bond)
SPERMIDINE T113 3.33x33 TM3 Van der Waals
SPERMIDINE T113 3.33x33 TM3 polar (hydrogen bond)
SPERMIDINE F168 4.61x61 TM4 hydrophobic
SPERMIDINE F168 4.61x61 TM4 Van der Waals
SPERMIDINE Y274 6.51x51 TM6 Van der Waals
SPERMIDINE Y274 6.51x51 TM6 hydrophobic
SPERMIDINE V297 7.39x38 TM7 hydrophobic
SPERMIDINE V297 7.39x38 TM7 Van der Waals
SPERMIDINE V300 7.42x41 TM7 Van der Waals
SPERMIDINE V300 7.42x41 TM7 hydrophobic
SPERMIDINE Y301 7.43x42 TM7 Van der Waals

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Snake plot — Download: PNG | SVG
ICL1 K Q L H ICL1ECL1 C W Y F ECL1ICL2 P L T Y P T K F ICL2ECL2 A N E E G I E E L V V A L T C V G G C Q A P L ECL2ICL3 A S S E S Y ICL3ECL3 N F I T ECL3N-term M T S D F S P E P P M E L C Y E N V N G S C I K N-termC-term G K V F R A D S S T T N L F S E E A G A G C-term S S Y A P W P R A I L Y G V L G L G A L L A V F G N L L V I I A I L H F T P T N F L V A S L A C A D F L V G V T V M P F S T V R S V E S G E S Y C K F H T C F D T S F C F A S L F H L C C I S I D R Y I A V T D T V S V S G L C I A L S W F F S V T Y S F S I F Y T G N Q N W V L L C F L L F F L P T V V M V F L Y G R I F L V A K Y Q A R K I E G T A N Q A Q K E R V A K R E R K A A K T L G I A M A A F L V S W L P Y I I D A V I D A Y M P A Y V Y E I L V W C V Y Y N S A M N P L I Y A F F Y P W I K L F R K A I V S
Helix box plot — Download: PNG | SVG L N G F V A L L A G L G L V G Y L I A R 1 A S L A C A D F L V G T V V M P F S T V R 2 C C L H F L S A F C F S T D F C T H F K 3 S G L C I A L S W F F S V T Y S F S I F 4 Y L F V M V V T P L F F L L F C L L V W 5 G I A M A A F L V S W L P Y I I D A V I 6 L P N M A S N Y Y V C W V L I E Y V Y 7

GPCRdb(A)
GPCRdb(A)
TAAR9
TM3
3x29 3.29x29 T109
3x32 3.32x32 D112
3x33 3.33x33 T113
TM4
4x61 4.61x61 F168
TM6
6x51 6.51x51 Y274
TM7
7x38 7.39x38 V297
7x41 7.42x41 V300
7x42 7.43x42 Y301