PDB
8IYX
Resolution
3.3 Å
Released
March 20, 2024
Receptor
GPR34
Class
A
Species
Homo sapiens
Ligand
Function
YL-365
Antagonist
Reference
10.1073/PNAS.2308435120

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Ligand Amino Acid Generic Number Segment Interaction Type
YL-365 G131 3.29x29 TM3 Van der Waals
YL-365 T132 3.30x30 TM3 hydrophobic
YL-365 Y135 3.33x33 TM3 hydrophobic
YL-365 Y135 3.33x33 TM3 aromatic (edge-to-face)
YL-365 M136 3.34x34 TM3 Van der Waals
YL-365 Y139 3.37x37 TM3 hydrophobic
YL-365 I140 3.38x38 TM3 Van der Waals
YL-365 I143 3.41x41 TM3 hydrophobic
YL-365 F147 3.45x45 TM3 hydrophobic
YL-365 V174 4.45x45 TM4 hydrophobic
YL-365 I177 4.48x48 TM4 hydrophobic
YL-365 V178 4.49x49 TM4 Van der Waals
YL-365 L181 4.52x52 TM4 hydrophobic
YL-365 A182 4.53x53 TM4 Van der Waals
YL-365 G185 4.56x56 TM4 Van der Waals
YL-365 M189 4.60x60 TM4 hydrophobic
YL-365 L223 5.43x43 TM5 Van der Waals

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Snake plot — Download: PNG | SVG
ICL1 R K R ICL1ECL1 N K W T L ECL1ICL2 I Q Q R K A I T T ICL2ECL2 G H N S T M C F H Y R D K H N A ECL2ICL3 R R S K F P N ICL3ECL3 Q L N V S ECL3N-term M R S H T I T M T T T S V S S W P Y S S H R M R F I T N H S D Q P P Q N F S A T P N V T T C P M D E K N-termC-term G E P S R S E S T S E F K P G Y S L H D T S V A V K I Q S S S K S T C-term L L S T V L T T S Y S V I F I V G L V G N I I A L Y V F L G I H N S I Q I Y L L N V A I A D L L L I F C L P F R I M Y H I N Q G V I L C K V V G T L F Y M N M Y I S I I L L G F I S L D R Y I K I N R S K Q S I Y V C C I V W M L A L G G F L T M I I L T L K K G K G E A I F N F I L V V M F W L I F L L I I L S Y I K I G K N L L R I S K S G K Y A T T A R N S F I V L I I F T I C F V P Y H A F R F I Y I S S S C Y W K E I V H K T N E I M L V L S S F N S C L D P V M Y F L M S S N M C Q R F Q I R K I L L F R
Helix box plot — Download: PNG | SVG I N G V L G V I F I V S Y S T T L V T S 1 L N V A I A D L L L I F C L P F R I M Y 2 F G L L I I S I Y M N M Y F L T G V V K 3 S I Y V C C I V W M L A L G G F L T M I 4 Y S L I I L L F I L W F M V V L I F N F 5 S F I V L I I F I T C F V P Y H A F R F I 6 V P D L C S N F S S L V L M I E N T K 7

GPCRdb(A)
GPCRdb(A)
GPR34
TM3
3x29 3.29x29 G131
3x30 3.30x30 T132
3x33 3.33x33 Y135
3x34 3.34x34 M136
3x37 3.37x37 Y139
3x38 3.38x38 I140
3x41 3.41x41 I143
3x45 3.45x45 F147
TM4
4x45 4.45x45 V174
4x48 4.48x48 I177
4x49 4.49x49 V178
4x52 4.52x52 L181
4x53 4.53x53 A182
4x56 4.56x56 G185
4x60 4.60x60 M189
TM5
5x43 5.43x43 L223