PDB
8IZB
Resolution
3.1 Å
Released
Nov. 1, 2023
Receptor
GPR174
Class
A
Species
Homo sapiens
Ligands
L-serine
LYSOPHOSPHATIDIC ACID
Function
Agonist
Agonist
Reference
10.1371/JOURNAL.PBIO.3002387
L-serine LYSOPHOSPHATIDIC ACID

NGL is a WebGL based 3D viewer powered by MMTF.

Download PDB file
Download list in excel
Ligand Amino Acid Generic Number Segment Interaction Type
L-serine R75 2.60x60 TM2 polar (charge-assisted hydrogen bond)
L-serine Y79 2.64x64 TM2 polar (hydrogen bond)
L-serine F95 3.29x29 TM3 hydrophobic
L-serine F95 3.29x29 TM3 Van der Waals
L-serine K98 3.32x32 TM3 Van der Waals
LYSOPHOSPHATIDIC ACID Y99 3.33x33 TM3 Van der Waals
L-serine Y99 3.33x33 TM3 polar (hydrogen bond)
L-serine Y99 3.33x33 TM3 Van der Waals
LYSOPHOSPHATIDIC ACID Y99 3.33x33 TM3 polar (hydrogen bond)
LYSOPHOSPHATIDIC ACID Y103 3.37x37 TM3 Van der Waals
LYSOPHOSPHATIDIC ACID Y103 3.37x37 TM3 hydrophobic
LYSOPHOSPHATIDIC ACID I144 4.52x52 TM4 hydrophobic
LYSOPHOSPHATIDIC ACID I144 4.52x52 TM4 Van der Waals
LYSOPHOSPHATIDIC ACID A148 4.56x56 TM4 hydrophobic
LYSOPHOSPHATIDIC ACID A148 4.56x56 TM4 Van der Waals
LYSOPHOSPHATIDIC ACID C149 4.57x57 TM4 Van der Waals
LYSOPHOSPHATIDIC ACID F152 4.60x60 TM4 hydrophobic
LYSOPHOSPHATIDIC ACID F152 4.60x60 TM4 Van der Waals
LYSOPHOSPHATIDIC ACID L155 4.63x63 TM4 Van der Waals
LYSOPHOSPHATIDIC ACID R156 ECL2 polar (charge-assisted hydrogen bond)
L-serine F169 45.51x51 ECL2 Van der Waals
LYSOPHOSPHATIDIC ACID V170 45.52x52 ECL2 Van der Waals
LYSOPHOSPHATIDIC ACID M185 5.38x39 TM5 hydrophobic
LYSOPHOSPHATIDIC ACID M185 5.38x39 TM5 Van der Waals
LYSOPHOSPHATIDIC ACID I192 5.45x46 TM5 hydrophobic
LYSOPHOSPHATIDIC ACID I192 5.45x46 TM5 Van der Waals
LYSOPHOSPHATIDIC ACID Y246 6.51x51 TM6 Van der Waals
LYSOPHOSPHATIDIC ACID Y246 6.51x51 TM6 polar (hydrogen bond)
LYSOPHOSPHATIDIC ACID F250 6.55x55 TM6 Van der Waals
LYSOPHOSPHATIDIC ACID F250 6.55x55 TM6 hydrophobic
LYSOPHOSPHATIDIC ACID D253 6.58x58 TM6 Van der Waals
LYSOPHOSPHATIDIC ACID F254 6.59x59 TM6 hydrophobic
LYSOPHOSPHATIDIC ACID F254 6.59x59 TM6 Van der Waals
LYSOPHOSPHATIDIC ACID K257 6.62x62 TM6 polar (charge-assisted hydrogen bond)
LYSOPHOSPHATIDIC ACID H274 7.35x34 TM7 Van der Waals
L-serine L278 7.39x38 TM7 Van der Waals

NGL is a WebGL based 3D viewer powered by MMTF.

Download PDB file

NGL is a WebGL based 3D viewer powered by MMTF.

Download PDB file

Snake plot — Download: PNG | SVG
ICL1 K R A ICL1ECL1 D W P F ECL1ICL2 P F R F H D C ICL2ECL2 T S D D T S G N R T K C F V D L P T R N V ECL2ICL3 Q D K Y P M A Q D L ICL3ECL3 E I K ECL3N-term M P A N Y T C T R P D G D N T D N-termC-term H D S I Q L H A K S F V S N H T A S T M T P E L C C-term F R Y F I Y A V T Y T V I L V P G L I G N I L A L W V F Y G Y M K E T V I F M I N L A I A D L L Q V L S L P L R I F Y Y L N H G P G L C M F C F Y L K Y V N M Y A S I Y F L V C I S V R R F W F L M Y K Q K Y D L Y I S I A G W L I I C L A C V L F P L L R N L A Q S V V M M T I G E L I G F V T P L L I V L Y C T W K T V L S L G E K Q K A L K M I L T C A G V F L I C F A P Y H F S F P L D F L V K S N S C L A R R V I L I F H S V A L C L A S L N S C L D P V I Y Y F S T N E L S R F R R R Q D L
Helix box plot — Download: PNG | SVG I N G I L G P V L I V T Y T V A Y I F Y 1 I N L A I A D L L Q V L S L P L R I F Y 2 C V L F Y I S A Y M N V Y K L Y F C F M 3 D L Y I S I A G W L I I C L A C V L F P 4 T C Y L V I L L P T V F G I L E G I T M M 5 L T C A G V F L I C F A P Y H F S F P L 6 V P D L C S N L S A L C L A V S H F I 7

GPCRdb(A)
GPCRdb(A)
GPR174
TM2
2x60 2.60x60 R75
2x64 2.64x64 Y79
TM3
3x29 3.29x29 F95
3x32 3.32x32 K98
3x33 3.33x33 Y99
3x37 3.37x37 Y103
TM4
4x52 4.52x52 I144
4x56 4.56x56 A148
4x57 4.57x57 C149
4x60 4.60x60 F152
4x63 4.63x63 L155
ECL2
45x51 45.51x51 F169
45x52 45.52x52 V170
TM5
5x39 5.38x39 M185
5x46 5.45x46 I192
TM6
6x51 6.51x51 Y246
6x55 6.55x55 F250
6x58 6.58x58 D253
6x59 6.59x59 F254
6x62 6.62x62 K257
TM7
7x34 7.35x34 H274
7x38 7.39x38 L278