PDB
8J20
Resolution
3.2 Å
Released
Jan. 24, 2024
Receptor
FFA3
Class
A
Species
Homo sapiens
Ligands
Function
AR420626
PAM
pentanoic acid
Agonist
Reference
10.1038/S41422-023-00914-Z
AR420626 pentanoic acid

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Ligand Amino Acid Generic Number Segment Interaction Type
AR420626 L54 2.43x43 TM2 hydrophobic
pentanoic acid F96 3.33x33 TM3 hydrophobic
pentanoic acid Y100 3.37x37 TM3 Van der Waals
AR420626 L106 3.43x43 TM3 hydrophobic
AR420626 R113 3.50x50 TM3 aromatic (pi-cation)
AR420626 R113 3.50x50 TM3 polar (hydrogen bond)
pentanoic acid C147 4.57x57 TM4 Van der Waals
pentanoic acid V150 4.60x60 TM4 hydrophobic
pentanoic acid R185 5.39x40 TM5 polar (hydrogen bond)
pentanoic acid R185 5.39x40 TM5 polar (charge-charge)
pentanoic acid M188 5.42x43 TM5 hydrophobic
AR420626 P196 5.50x50 TM5 Van der Waals
AR420626 L197 5.51x51 TM5 hydrophobic
AR420626 T200 5.54x54 TM5 hydrophobic
AR420626 S201 5.55x55 TM5 Van der Waals
AR420626 Y204 5.58x58 TM5 hydrophobic
AR420626 Y204 5.58x58 TM5 aromatic (edge-to-face)
AR420626 L226 6.36x37 TM6 Van der Waals
AR420626 V227 6.37x38 TM6 hydrophobic
AR420626 V227 6.37x38 TM6 halogen contact
AR420626 T230 6.40x41 TM6 polar (hydrogen bond with backbone)
AR420626 T230 6.40x41 TM6 hydrophobic
AR420626 L231 6.41x42 TM6 hydrophobic
AR420626 F234 6.44x45 TM6 hydrophobic
pentanoic acid Y241 6.51x51 TM6 polar (hydrogen bond)
pentanoic acid H245 6.55x55 TM6 Van der Waals
pentanoic acid R258 7.35x34 TM7 polar (charge-charge)
pentanoic acid R258 7.35x34 TM7 polar (hydrogen bond)
AR420626 D272 7.49x49 TM7 Van der Waals
AR420626 V275 7.52x52 TM7 hydrophobic
AR420626 Y276 7.53x53 TM7 hydrophobic

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Snake plot — Download: PNG | SVG
ICL1 P ICL1ECL1 E A A N G M H W P L ECL1ICL2 P L W Y K T R P ICL2ECL2 S G D I S H S Q G T N G T C Y L E F R K D ECL2ICL3 G G ICL3ECL3 E S P A ECL3N-term M D T G P D Q S Y F N-termC-term C G L W G Q W Q Q E S S M E L K E Q K G G E E Q R A D R P A E R K T S E H S Q G C G T G G Q V A C A E S C-term S G N H W F V F S V Y L L T F L V G L P L N L L A L V V F V G K L Q R R V A V D V L L L N L T A S D L L L L L F L P F R M V P F I L C P L S G F I F F T T I Y L T A L F L A A V S I E R F L S V A H R L G Q A G L V S V A C W L L A S A H C S V V Y V I E F Q L A I L L P V R L E M A V V L F V V P L I I T S Y C Y S R L V W I L G R S H R R Q R R V A G L L A A T L L N F L V C F G P Y N V S H V V G Y I C G W R I Y V T L L S T L N S C V D P F V Y Y F S S S G F H E L F Q A D L L R R
Helix box plot — Download: PNG | SVG L N L P L G V L F T L L Y V S F V F W H 1 L N L T A S D L L L L L F L P F R M V 2 A A L F L A T L Y I T T F F I F G S L P 3 A G L V S V A C W L L A S A H C S V V Y 4 Y C Y S T I I L P V V F L V V A M E L R V 5 L A A T L L N F V L C F G P Y N V S H V V 6 F P D V C S N L T S L L T V Y I R W 7

GPCRdb(A)
GPCRdb(A)
FFA3 receptor
TM2
2x43 2.43x43 L54
TM3
3x33 3.33x33 F96
3x37 3.37x37 Y100
3x43 3.43x43 L106
3x50 3.50x50 R113
TM4
4x57 4.57x57 C147
4x60 4.60x60 V150
TM5
5x40 5.39x40 R185
5x43 5.42x43 M188
5x50 5.50x50 P196
5x51 5.51x51 L197
5x54 5.54x54 T200
5x55 5.55x55 S201
5x58 5.58x58 Y204
TM6
6x37 6.36x37 L226
6x38 6.37x38 L227
6x41 6.40x41 T230
6x42 6.41x42 L231
6x45 6.44x45 F234
6x51 6.51x51 Y241
6x55 6.55x55 H245
TM7
7x34 7.35x34 R258
7x49 7.49x49 D272
7x52 7.52x52 V275
7x53 7.53x53 Y276