PDB
8JD3
Resolution
3.3 Å
Released
June 21, 2023
Receptor
mGlu2
Class
C
Species
Homo sapiens
Ligands
L-glutamic acid
JNJ-40411813
Function
Agonist
PAM
Reference
10.1038/S41422-023-00830-2
L-glutamic acid JNJ-40411813

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Ligand Amino Acid Generic Number Segment Interaction Type
L-glutamic acid R57 N-term polar (charge-assisted hydrogen bond)
L-glutamic acid R61 N-term polar (charge-assisted hydrogen bond)
L-glutamic acid S143 N-term polar (hydrogen bond with backbone)
L-glutamic acid S143 N-term polar (hydrogen bond)
L-glutamic acid S143 N-term Van der Waals
L-glutamic acid Y144 N-term hydrophobic
L-glutamic acid Y144 N-term Van der Waals
L-glutamic acid S145 N-term polar (hydrogen bond)
L-glutamic acid S145 N-term polar (hydrogen bond with backbone)
L-glutamic acid S145 N-term Van der Waals
L-glutamic acid A166 N-term Van der Waals
L-glutamic acid A166 N-term polar (hydrogen bond with backbone)
L-glutamic acid S167 N-term Van der Waals
L-glutamic acid T168 N-term polar (hydrogen bond with backbone)
L-glutamic acid T168 N-term polar (hydrogen bond)
L-glutamic acid T168 N-term Van der Waals
L-glutamic acid Y216 N-term Van der Waals
L-glutamic acid Y216 N-term hydrophobic
L-glutamic acid D295 N-term polar (charge-assisted hydrogen bond)
L-glutamic acid K377 N-term Van der Waals
JNJ-40411813 L639 3.36x36 TM3 hydrophobic
JNJ-40411813 F643 3.40x40 TM3 hydrophobic
JNJ-40411813 Y647 3.44x44 TM3 hydrophobic
JNJ-40411813 A726 5.38x38 TM5 hydrophobic
JNJ-40411813 M728 5.40x40 TM5 hydrophobic
JNJ-40411813 L732 5.44x44 TM5 hydrophobic
JNJ-40411813 N735 5.47x47 TM5 Van der Waals
JNJ-40411813 N735 5.47x47 TM5 polar (hydrogen bond)
JNJ-40411813 I739 5.51x51 TM5 Van der Waals
JNJ-40411813 W773 6.50x50 TM6 aromatic (face-to-edge)
JNJ-40411813 W773 6.50x50 TM6 Van der Waals
JNJ-40411813 F776 6.53x53 TM6 hydrophobic
JNJ-40411813 F776 6.53x53 TM6 Van der Waals
JNJ-40411813 F780 6.57x57 TM6 Van der Waals
JNJ-40411813 F780 6.57x57 TM6 hydrophobic

NGL is a WebGL based 3D viewer powered by MMTF.

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NGL is a WebGL based 3D viewer powered by MMTF.

Download PDB file

Snake plot — Download: PNG | SVG
ICL1 T N A P V V K A S ICL1ECL1 K P ECL1ICL2 A R E G A Q R P R F I ICL2ECL2 A P G T G K E T A P E R R E V V T L R C N H R ECL2ICL3 P E N ICL3ECL3 S ECL3N-term M G S L L A L L A L L L L W G A V A E G P A K K V L T L E G D L V L G G L F P V H Q K G G P A E D C G P V N E H R G I Q R L E A M L F A L D R I N R D P H L L P G V R L G A H I L D S C S K D T H A L E Q A L D F V R A S L S R G A D G S R H I C P D G S Y A T H G D A P T A I T G V I G G S Y S D V S I Q V A N L L R L F Q I P Q I S Y A S T S A K L S D K S R Y D Y F A R T V P P D F F Q A K A M A E I L R F F N W T Y V S T V A S E G D Y G E T G I E A F E L E A R A R N I C V A T S E K V G R A M S R A A F E G V V R A L L Q K P S A R V A V L F T R S E D A R E L L A A S Q R L N A S F T W V A S D G W G A L E S V V A G S E G A A E G A I T I E L A S Y P I S D F A S Y F Q S L D P W N N S R N P W F R E F W E Q R F R C S F R Q R D C A A H S L R A V P F E Q E S K I M F V V N A V Y A M A H A L H N M H R A L C P N T T R L C D A M R P V N G R R L Y K D F V L N V K F D A P F R P A D T H N E V R F D R F G D G I G R Y N I F T Y L R A G S G R Y R Y Q K V G Y W A E G L T L D T S L I P W A S P S A G P L P A S R C S E P C L Q N E V K S V Q P G E V C C W L C I P C Q P Y E Y R L D E F T C A D C G L G Y W P N A S L T G C F E L P Q E Y I R W N-termC-term S R F G S A A A R A S S S L G Q G S G S Q F V P T V C N G R E V V D S T T S S L C-term G D A W A V G P V T I A C L G A L A T L F V L G V F V R H G R E L C Y I L L G G V F L C Y C M T F I F I A S T A V C T L R R L G L G T A F S V C Y S A L L T K T N R I A R I F G G S P A S Q V A I C L A L I S G Q L L I V V A W L V V E D A S M L G S L A Y N V L L I A L C T L Y A F K T R K C F N E A K F I G F T M Y T T C I I W L A F L P I F Y V T S D Y R V Q T T T M C V S V S L S G S V V L G C L F A P K L H I I L F Q P Q K H R A N V V S P T
Helix box plot — Download: PNG | SVG L T A L A G L C A I T V P G V A W A D G 1 Y I L L G G V F L C Y C M T F I F I A 2 T L L A S Y C V S F A T G L G L R R L T 3 Q V A I C L A L I S G Q L L I V V A W L 4 A Y L T C L A I L L V N Y A L S G L M S 5 G F T M Y T T C I I W L A F L P I F Y V 6 G L V V S G S L S V S V C M T T T Q V R 7

GPCRdb(A)
GPCRdb(C)
mGlu2 receptor
TM3
3x32 3.36x36 L639
3x36 3.40x40 F643
3x40 3.44x44 Y647
TM5
5x38 5.38x38 A726
5x40 5.40x40 M728
5x44 5.44x44 L732
5x47 5.47x47 N735
5x51 5.51x51 I739
TM6
6x48 6.50x50 W773
6x51 6.53x53 F776
6x55 6.57x57 F780