PDB
8JD5
Resolution
3.6 Å
Released
June 21, 2023
Receptor
mGlu2
Class
C
Species
Homo sapiens
Ligands
L-glutamic acid
JNJ-40411813
ADX88178
Function
Agonist
PAM
PAM
Reference
10.1038/S41422-023-00830-2
L-glutamic acid JNJ-40411813 ADX88178

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Ligand Amino Acid Generic Number Segment Interaction Type
L-glutamic acid R57 N-term polar (charge-assisted hydrogen bond)
L-glutamic acid R61 N-term polar (charge-assisted hydrogen bond)
L-glutamic acid S143 N-term polar (hydrogen bond)
L-glutamic acid Y144 N-term Van der Waals
L-glutamic acid S145 N-term polar (hydrogen bond with backbone)
L-glutamic acid S145 N-term Van der Waals
L-glutamic acid A166 N-term Van der Waals
L-glutamic acid T168 N-term polar (hydrogen bond)
L-glutamic acid T168 N-term Van der Waals
L-glutamic acid Y216 N-term hydrophobic
L-glutamic acid Y216 N-term Van der Waals
L-glutamic acid K377 N-term polar (charge-assisted hydrogen bond)
JNJ-40411813 L639 3.36x36 TM3 hydrophobic
JNJ-40411813 F643 3.40x40 TM3 hydrophobic
JNJ-40411813 Y647 3.44x44 TM3 hydrophobic
JNJ-40411813 M728 5.40x40 TM5 hydrophobic
JNJ-40411813 L732 5.44x44 TM5 hydrophobic
JNJ-40411813 N735 5.47x47 TM5 Van der Waals
JNJ-40411813 N735 5.47x47 TM5 polar (hydrogen bond)
JNJ-40411813 I739 5.51x51 TM5 Van der Waals
JNJ-40411813 I739 5.51x51 TM5 hydrophobic
JNJ-40411813 T769 6.46x46 TM6 Van der Waals
ADX88178 I771 6.48x48 TM6 hydrophobic
JNJ-40411813 W773 6.50x50 TM6 hydrophobic
JNJ-40411813 W773 6.50x50 TM6 Van der Waals
ADX88178 L774 6.51x51 TM6 polar (hydrogen bond with backbone)
ADX88178 L774 6.51x51 TM6 Van der Waals
ADX88178 A775 6.52x52 TM6 Van der Waals
ADX88178 A775 6.52x52 TM6 hydrophobic
JNJ-40411813 L777 6.54x54 TM6 hydrophobic
JNJ-40411813 L777 6.54x54 TM6 Van der Waals
ADX88178 L777 6.54x54 TM6 hydrophobic
ADX88178 L777 6.54x54 TM6 Van der Waals
ADX88178 P778 6.55x55 TM6 hydrophobic
ADX88178 P778 6.55x55 TM6 Van der Waals
JNJ-40411813 F780 6.57x57 TM6 Van der Waals
JNJ-40411813 F780 6.57x57 TM6 hydrophobic
JNJ-40411813 Y781 6.58x58 TM6 aromatic (face-to-edge)
JNJ-40411813 Y781 6.58x58 TM6 Van der Waals

NGL is a WebGL based 3D viewer powered by MMTF.

Download PDB file

NGL is a WebGL based 3D viewer powered by MMTF.

Download PDB file

NGL is a WebGL based 3D viewer powered by MMTF.

Download PDB file

Snake plot — Download: PNG | SVG
ICL1 T N A P V V K A S ICL1ECL1 K P ECL1ICL2 A R E G A Q R P R F I ICL2ECL2 A P G T G K E T A P E R R E V V T L R C N H R ECL2ICL3 P E N ICL3ECL3 S ECL3N-term M G S L L A L L A L L L L W G A V A E G P A K K V L T L E G D L V L G G L F P V H Q K G G P A E D C G P V N E H R G I Q R L E A M L F A L D R I N R D P H L L P G V R L G A H I L D S C S K D T H A L E Q A L D F V R A S L S R G A D G S R H I C P D G S Y A T H G D A P T A I T G V I G G S Y S D V S I Q V A N L L R L F Q I P Q I S Y A S T S A K L S D K S R Y D Y F A R T V P P D F F Q A K A M A E I L R F F N W T Y V S T V A S E G D Y G E T G I E A F E L E A R A R N I C V A T S E K V G R A M S R A A F E G V V R A L L Q K P S A R V A V L F T R S E D A R E L L A A S Q R L N A S F T W V A S D G W G A L E S V V A G S E G A A E G A I T I E L A S Y P I S D F A S Y F Q S L D P W N N S R N P W F R E F W E Q R F R C S F R Q R D C A A H S L R A V P F E Q E S K I M F V V N A V Y A M A H A L H N M H R A L C P N T T R L C D A M R P V N G R R L Y K D F V L N V K F D A P F R P A D T H N E V R F D R F G D G I G R Y N I F T Y L R A G S G R Y R Y Q K V G Y W A E G L T L D T S L I P W A S P S A G P L P A S R C S E P C L Q N E V K S V Q P G E V C C W L C I P C Q P Y E Y R L D E F T C A D C G L G Y W P N A S L T G C F E L P Q E Y I R W N-termC-term S R F G S A A A R A S S S L G Q G S G S Q F V P T V C N G R E V V D S T T S S L C-term G D A W A V G P V T I A C L G A L A T L F V L G V F V R H G R E L C Y I L L G G V F L C Y C M T F I F I A S T A V C T L R R L G L G T A F S V C Y S A L L T K T N R I A R I F G G S P A S Q V A I C L A L I S G Q L L I V V A W L V V E D A S M L G S L A Y N V L L I A L C T L Y A F K T R K C F N E A K F I G F T M Y T T C I I W L A F L P I F Y V T S D Y R V Q T T T M C V S V S L S G S V V L G C L F A P K L H I I L F Q P Q K H R A N V V S P T
Helix box plot — Download: PNG | SVG L T A L A G L C A I T V P G V A W A D G 1 Y I L L G G V F L C Y C M T F I F I A 2 T L L A S Y C V S F A T G L G L R R L T 3 Q V A I C L A L I S G Q L L I V V A W L 4 A Y L T C L A I L L V N Y A L S G L M S 5 G F T M Y T T C I I W L A F L P I F Y V 6 G L V V S G S L S V S V C M T T T Q V R 7

GPCRdb(A)
GPCRdb(C)
mGlu2 receptor
TM3
3x32 3.36x36 L639
3x36 3.40x40 F643
3x40 3.44x44 Y647
TM5
5x40 5.40x40 M728
5x44 5.44x44 L732
5x47 5.47x47 N735
5x51 5.51x51 I739
TM6
6x44 6.46x46 T769
6x46 6.48x48 I771
6x48 6.50x50 W773
6x49 6.51x51 L774
6x50 6.52x52 A775
6x52 6.54x54 L777
6x53 6.55x55 P778
6x55 6.57x57 F780
6x56 6.58x58 Y781