PDB
8JHY
Resolution
2.9 Å
Released
Sept. 6, 2023
Receptor
HCA2
Class
A
Species
Homo sapiens
Ligand
compound 9n [PMID: 18752940]
Function
Ago-PAM
Reference
10.1016/J.MOLCEL.2023.07.030

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Ligand Amino Acid Generic Number Segment Interaction Type
compound 9n [PMID: 18752940] H184 ECL2 aromatic (edge-to-face)
compound 9n [PMID: 18752940] F186 ECL2 hydrophobic
compound 9n [PMID: 18752940] A191 5.41x42 TM5 Van der Waals
compound 9n [PMID: 18752940] A191 5.41x42 TM5 polar (hydrogen bond with backbone)
compound 9n [PMID: 18752940] L194 5.44x45 TM5 Van der Waals
compound 9n [PMID: 18752940] L194 5.44x45 TM5 hydrophobic
compound 9n [PMID: 18752940] L195 5.45x46 TM5 hydrophobic
compound 9n [PMID: 18752940] L195 5.45x46 TM5 Van der Waals
compound 9n [PMID: 18752940] F198 5.48x48 TM5 hydrophobic
compound 9n [PMID: 18752940] F255 6.59x59 TM6 hydrophobic
compound 9n [PMID: 18752940] F255 6.59x59 TM6 Van der Waals
compound 9n [PMID: 18752940] L258 6.62x62 TM6 Van der Waals
compound 9n [PMID: 18752940] L258 6.62x62 TM6 hydrophobic

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Snake plot — Download: PNG | SVG
ICL1 L K S W ICL1ECL1 W D W K F ECL1ICL2 P H H A L N K I ICL2ECL2 M P I Q N G G A N L C S S F S I C H T F ECL2ICL3 M D R H A ICL3ECL3 G T Q N C E V ECL3N-term M N R H H L Q D H F L E I D K K N C C V F R D D N-termC-term Q R K M T G E P D N N R S T S V E L T G D P N K T R G A P E A L M A N S G E P W S P S Y L G P T S P C-term F I V K V L P P V L G L E F I F G L L G N G L A L W I F C F H K S S R I F L F N L A V A D F L L I I C L P F L M D N Y V R R G D I P C R L M L F M L A M N R Q G S I I F L T V V A V D R Y F R V V H S N R T A A I I S C L L W G I T I G L T V H L L K K K Q W H E A M F L L E F F L P L G I I L F C S A R I I W S L R Q R Q K I K R A I T F I M V V A I V F V I C F L P S V V V R I R I F W L L H T S Y R S V D L A F F I T L S F T Y M N S M L D P V V Y Y F S S P S F S T C L F P N F L I N R
Helix box plot — Download: PNG | SVG G N G L L G F I F E L G L V P P L V K V 1 F N L A V A D F L L I I C L P F L M D N 2 V T L F I I S G Q R N M A L M F L M L R 3 A A I I S C L L W G I T I G L T V H L L 4 S C F L I I G L P L F F E L L F M A E H W 5 M V V A I V F V I C F L P S V V V R I R 6 V P D L M S N M Y T F S L T I F F A L 7

GPCRdb(A)
GPCRdb(A)
HCA2 receptor
TM5
5x42 5.41x42 A191
5x45 5.44x45 L194
5x46 5.45x46 L195
5x48 5.48x48 F198
TM6
6x59 6.59x59 F255
6x62 6.62x62 L258