PDB
8JIM
Resolution
3.0 Å
Released
Sept. 6, 2023
Receptor
HCA2
Class
A
Species
Homo sapiens
Ligand
monomethyl fumarate
Function
Agonist
Reference
10.1016/J.MOLCEL.2023.07.030

NGL is a WebGL based 3D viewer powered by MMTF.

Download PDB file
Download list in excel
Ligand Amino Acid Generic Number Segment Interaction Type
monomethyl fumarate L83 2.60x60 TM2 hydrophobic
monomethyl fumarate Y87 2.64x64 TM2 Van der Waals
monomethyl fumarate Y87 2.64x64 TM2 polar (hydrogen bond)
monomethyl fumarate L104 3.29x29 TM3 Van der Waals
monomethyl fumarate L107 3.32x32 TM3 Van der Waals
monomethyl fumarate L107 3.32x32 TM3 hydrophobic
monomethyl fumarate R111 3.36x36 TM3 polar (charge-assisted hydrogen bond)
monomethyl fumarate S178 45.51x51 ECL2 Van der Waals
monomethyl fumarate S179 45.52x52 ECL2 Van der Waals
monomethyl fumarate F180 ECL2 hydrophobic
monomethyl fumarate L280 7.39x38 TM7 Van der Waals
monomethyl fumarate Y284 7.43x42 TM7 polar (hydrogen bond)
monomethyl fumarate Y284 7.43x42 TM7 Van der Waals

NGL is a WebGL based 3D viewer powered by MMTF.

Download PDB file

Snake plot — Download: PNG | SVG
ICL1 L K S W ICL1ECL1 W D W K F ECL1ICL2 P H H A L N K I ICL2ECL2 M P I Q N G G A N L C S S F S I C H T F ECL2ICL3 M D R H A ICL3ECL3 G T Q N C E V ECL3N-term M N R H H L Q D H F L E I D K K N C C V F R D D N-termC-term Q R K M T G E P D N N R S T S V E L T G D P N K T R G A P E A L M A N S G E P W S P S Y L G P T S P C-term F I V K V L P P V L G L E F I F G L L G N G L A L W I F C F H K S S R I F L F N L A V A D F L L I I C L P F L M D N Y V R R G D I P C R L M L F M L A M N R Q G S I I F L T V V A V D R Y F R V V H S N R T A A I I S C L L W G I T I G L T V H L L K K K Q W H E A M F L L E F F L P L G I I L F C S A R I I W S L R Q R Q K I K R A I T F I M V V A I V F V I C F L P S V V V R I R I F W L L H T S Y R S V D L A F F I T L S F T Y M N S M L D P V V Y Y F S S P S F S T C L F P N F L I N R
Helix box plot — Download: PNG | SVG G N G L L G F I F E L G L V P P L V K V 1 F N L A V A D F L L I I C L P F L M D N 2 V T L F I I S G Q R N M A L M F L M L R 3 A A I I S C L L W G I T I G L T V H L L 4 S C F L I I G L P L F F E L L F M A E H W 5 M V V A I V F V I C F L P S V V V R I R 6 V P D L M S N M Y T F S L T I F F A L 7

GPCRdb(A)
GPCRdb(A)
HCA2 receptor
TM2
2x60 2.60x60 L83
2x64 2.64x64 Y87
TM3
3x29 3.29x29 L104
3x32 3.32x32 L107
3x36 3.36x36 R111
ECL2
45x51 45.51x51 S178
45x52 45.52x52 S179
TM7
7x38 7.39x38 L280
7x42 7.43x42 Y284