Structure information

GLP-1 receptor

PROTEIN CLASS

Class B1 (Secretin)

PDB CODE

8JIP

SPECIES

Homo sapiens

RESOLUTION

2.850

PREFERRED CHAIN

R

REFERENCE

10.1073/PNAS.2303696120

PUBLICATION DATE

Sept. 6, 2023

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
MEDI0382 L32 N-term Van der Waals
MEDI0382 L32 N-term polar (hydrogen bond with backbone)
MEDI0382 T35 N-term Van der Waals
MEDI0382 V36 N-term hydrophobic
MEDI0382 V36 N-term Van der Waals
MEDI0382 W39 N-term aromatic (face-to-edge)
MEDI0382 W39 N-term Van der Waals
MEDI0382 E68 N-term Van der Waals
MEDI0382 Y69 N-term Van der Waals
MEDI0382 P86 N-term Van der Waals
MEDI0382 Y88 N-term polar (hydrogen bond)
MEDI0382 Y88 N-term polar (hydrogen bond)
MEDI0382 L89 N-term hydrophobic
MEDI0382 L89 N-term Van der Waals
MEDI0382 E138 N-term Van der Waals
MEDI0382 L141 1.36x36 TM1 Van der Waals
MEDI0382 L141 1.36x36 TM1 hydrophobic
MEDI0382 L144 1.39x39 TM1 hydrophobic
MEDI0382 Y145 1.40x40 TM1 polar (hydrogen bond)
MEDI0382 I146 1.41x41 TM1 Van der Waals
MEDI0382 I146 1.41x41 TM1 hydrophobic
MEDI0382 Y148 1.43x43 TM1 aromatic (edge-to-face)
MEDI0382 Y148 1.43x43 TM1 Van der Waals
MEDI0382 T149 1.44x44 TM1 Van der Waals
MEDI0382 V150 1.45x45 TM1 Van der Waals
MEDI0382 Y152 1.47x47 TM1 Van der Waals
MEDI0382 Y152 1.47x47 TM1 polar (hydrogen bond)
MEDI0382 A153 1.48x48 TM1 polar (hydrogen bond with backbone)
MEDI0382 A153 1.48x48 TM1 Van der Waals
MEDI0382 L154 1.49x49 TM1 polar (hydrogen bond with backbone)
MEDI0382 L154 1.49x49 TM1 Van der Waals
MEDI0382 S157 1.52x52 TM1 polar (hydrogen bond)
MEDI0382 K197 2.67x67 TM2 polar (charge-assisted hydrogen bond)
MEDI0382 K202 2.72x72 TM2 polar (charge-assisted hydrogen bond)
MEDI0382 Y205 2.75x75 TM2 polar (hydrogen bond)
MEDI0382 Y205 2.75x75 TM2 polar (hydrogen bond)
MEDI0382 S206 ECL1 Van der Waals
MEDI0382 W214 ECL1 aromatic (face-to-face)
MEDI0382 W214 ECL1 Van der Waals
MEDI0382 V237 3.40x40 TM3 hydrophobic
MEDI0382 V237 3.40x40 TM3 Van der Waals
MEDI0382 T298 45.52x52 ECL2 Van der Waals
MEDI0382 R299 ECL2 polar (charge-assisted hydrogen bond)
MEDI0382 N300 ECL2 Van der Waals
MEDI0382 W306 5.36x37 TM5 Van der Waals
MEDI0382 W306 5.36x37 TM5 hydrophobic
MEDI0382 R380 7.35x34 TM7 polar (charge-assisted hydrogen bond)
MEDI0382 L384 7.39x38 TM7 Van der Waals
MEDI0382 E387 7.42x41 TM7 Van der Waals
MEDI0382 L388 7.43x42 TM7 Van der Waals
MEDI0382 L388 7.43x42 TM7 hydrophobic

Ligands

MEDI0382

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Residue Diagrams

V L A S F S L A Y G V T Y I I Y L F L L 1 L N L F A S F I L R A L S V F I K D A A 2 V L L W Y Y N A A V C Y Q M L L F V L R 3 I F R L Y V S G I W G V P L L F V V P W G 4 F I L F N V G I A F L I P L R I I L W Y N 5 L T L I P L L G T H E V I F A F V M 6 I A V M L G Q F S T F S L E T F L K I 7
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ICL1 R H L H ICL1ECL1 T A A Q Q H Q W D G L L S Y Q D S ECL1ICL2 S V L ICL2ECL2 D E G C W T R N S ECL2ICL3 M ICL3ECL3 D E H A R ECL3N-term M A G A P G P L R L A L L L L G M V G R A G P R P Q G A T V S L W E T V Q K W R E Y R R Q C Q R S L T E D P P P A T D L F C N R T F D E Y A C W P D G E P G S F V N V S C P W Y L P W A S S V P Q G H V Y R F C T A E G L W L Q K D N S S L P W R D L S E C E E S K R G E R S S P N-termC-term S M K P L K C P T S S L S S G A T A G S S M Y T A T C Q A S C S C-term E E Q L L F L Y I I Y T V G Y A L S F S A L V I A S A I L L G F C T R N Y I H L N L F A S F I L R A L S V F I K D A A L K W M Y S L S C R L V F L L M Q Y C V A A N Y Y W L L V E G V Y L Y T L L A F S E Q W I F R L Y V S I G W G V P L L F V V P W G I V K Y L Y E N M N Y W L I I R L P I L F A I G V N F L I F V R V I C I V V S K L K A N L C K T D I K C R L A K S T L T L I P L L G T H E V I F A F V M G T L R F I K L F T E L S F T S F Q G L M V A I L Y C F V N N E F R K W R L I Q R V Q L E S W E R E H L H D S
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Residue Table


GPCRdb(A)
GPCRdb(B)
GLP-1 receptor
TM1
1x32 1.36x36 L141
1x35 1.39x39 L144
1x36 1.40x40 Y145
1x37 1.41x41 I146
1x39 1.43x43 Y148
1x40 1.44x44 T149
1x41 1.45x45 V150
1x43 1.47x47 Y152
1x44 1.48x48 A153
1x45 1.49x49 L154
1x48 1.52x52 S157
TM2
2x60 2.67x67 K197
2x65 2.72x72 K202
2x68 2.75x75 Y205
TM3
3x36 3.40x40 V237
ECL2
45x52 45.52x52 T298
TM5
5x41 5.36x37 W306
TM7
7x30 7.35x34 R380
7x34 7.39x38 L384
7x37 7.42x41 E387
7x38 7.43x42 L388