PDB
8JLP
Resolution
3.2 Å
Released
Nov. 15, 2023
Receptor
TA1
Class
A
Species
Homo sapiens
Ligand
Function
ralmitaront
Agonist
Reference
10.1038/S41586-023-06804-Z

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Ligand Amino Acid Generic Number Segment Interaction Type
ralmitaront D103 3.32x32 TM3 polar (charge-charge)
ralmitaront D103 3.32x32 TM3 polar (hydrogen bond)
ralmitaront I104 3.33x33 TM3 Van der Waals
ralmitaront S107 3.36x36 TM3 Van der Waals
ralmitaront S108 3.37x37 TM3 polar (hydrogen bond)
ralmitaront F112 3.41x41 TM3 hydrophobic
ralmitaront V150 4.52x52 TM4 Van der Waals
ralmitaront P151 4.53x53 TM4 Van der Waals
ralmitaront F154 4.56x56 TM4 Van der Waals
ralmitaront V184 45.52x52 ECL2 Van der Waals
ralmitaront F186 ECL2 Van der Waals
ralmitaront T194 5.42x43 TM5 Van der Waals
ralmitaront T197 5.45x46 TM5 Van der Waals
ralmitaront S198 5.46x461 TM5 Van der Waals
ralmitaront W264 6.48x48 TM6 Van der Waals
ralmitaront F267 6.51x51 TM6 Van der Waals
ralmitaront F268 6.52x52 TM6 aromatic (edge-to-face)
ralmitaront I290 7.39x38 TM7 Van der Waals

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ICL1 K Q L H ICL1ECL1 C W Y F ECL1ICL2 P L R Y K A K M ICL2ECL2 L N F K G A E E I Y Y K H V H C R G G C S V F F ECL2ICL3 I G L E M K ICL3ECL3 H Y I I ECL3N-term M M P F C H N I I N I S C V K N N W S N N-termC-term G K I F Q K D S S R C K L F L E L S S C-term D V R A S L Y S L M V L I I L T T L V G N L I V I V S I S H F T P T N W L I H S M A T V D F L L G C L V M P Y S M V R S A E H G E V F C K I H T S T D I M L S S A S I F H L S F I S I D R Y Y A V C D N I L V I C V M I F I S W S V P A V F A F G M I F L E S K I S G V L T F M T S F Y I P G S I M L C V Y Y R I Y L I A K E Q A R L I S D A N Q K L Q N G I S Q S K E R K A V K T L G I V M G V F L I C W C P F F I C T V M D P F L P P T L N D V L I W F G Y L N S T F N P M V Y A F F Y P W L K M F R K A M L F
Helix box plot — Download: PNG | SVG L N G V L T T L I I L V M L S Y L S A R 1 H S M A T V D F L L G L C V M P Y S M V R 2 F S L H F I S A S S L M I D T S T H I K 3 I C V M I F I S W S V P A V F A F G M I 4 Y V C L M I S G P I Y F S T M F T L V G S 5 G I V M G V F L I C W C P F F I C T V M 6 M P N F T S N L Y G F W I L V D N L T 7

GPCRdb(A)
GPCRdb(A)
TA1 receptor
TM3
3x32 3.32x32 D103
3x33 3.33x33 I104
3x36 3.36x36 S107
3x37 3.37x37 S108
3x41 3.41x41 F112
TM4
4x52 4.52x52 V150
4x53 4.53x53 P151
4x56 4.56x56 F154
ECL2
45x52 45.52x52 V184
TM5
5x43 5.42x43 T194
5x46 5.45x46 T197
5x461 5.46x461 S198
TM6
6x48 6.48x48 W264
6x51 6.51x51 F267
6x52 6.52x52 F268
TM7
7x38 7.39x38 I290