PDB
8JLZ
Resolution
3.1 Å
Released
June 28, 2023
Receptor
5-HT6
Class
A
Species
Homo sapiens
Ligand
Function
CHEMBL365751
Agonist
Reference
10.1016/J.BBRC.2023.05.126

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Ligand Amino Acid Generic Number Segment Interaction Type
CHEMBL365751 D106 3.32x32 TM3 polar (charge-charge)
CHEMBL365751 V107 3.33x33 TM3 Van der Waals
CHEMBL365751 C110 3.36x36 TM3 hydrophobic
CHEMBL365751 S111 3.37x37 TM3 Van der Waals
CHEMBL365751 L182 45.52x52 ECL2 hydrophobic
CHEMBL365751 A184 ECL2 hydrophobic
CHEMBL365751 F188 5.38x39 TM5 hydrophobic
CHEMBL365751 A192 5.42x43 TM5 Van der Waals
CHEMBL365751 S193 5.43x44 TM5 Van der Waals
CHEMBL365751 W281 6.48x48 TM6 Van der Waals
CHEMBL365751 F284 6.51x51 TM6 Van der Waals
CHEMBL365751 F285 6.52x52 TM6 aromatic (edge-to-face)
CHEMBL365751 Y310 7.43x42 TM7 Van der Waals

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ICL1 P A L R ICL1ECL1 R W V L ECL1ICL2 P L R Y K L R M ICL2ECL2 W H E L G H A R P P V P G Q C R L L A ECL2ICL3 T G M A S Q A S E T L Q V P R T P R P G V E S A D S R R L A ICL3ECL3 D C I ECL3N-term M V P E P G P T A N S T P A W G A G P P S A P G G N-termC-term P R C P R E R Q A S L A S P S L R T S H S G P R P G L S L Q Q V L P L P L P P D S D S D S D A G S G G S S G L R L T A Q L L L P G E A T Q D P P L P T R A A A A V N F F N I D P A E P E L R P H P L G I P T N C-term S G W V A A A L C V V I A L T A A A N S L L I A L I C T Q N T S N F F L V S L F T S D L M V G L V V M P P A M L N A L Y G A R G L C L L W T A F D V M C C S A S I L N L C L I S L D R Y L L I L S T P L R A L A L V L G A W S L A A L A S F L P L L L G S L P F V L V A S G L T F F L P S G A I C F T Y C R I L L A A R K Q A V Q V A S L T T K H S R K A L K A S L T L G I L L G M F F V T W L P F F V A N I V Q A V C S P G L F D V L T W L G Y C N S T M N P I I Y P L F M R D L G R F K R A F L P C
Helix box plot — Download: PNG | SVG S N A A A T L A I V V C L A A A V W G S 1 V S L F T S D L M V G V L V M P P A M L N 2 L C L N L I S A S C C M V D F A T W L L 3 A L A L V L G A W S L A A L A S F L P L 4 Y T F C I A G S P L F F T L G S A V L V F 5 G I L L G M F F V T W L P F F V A N I V 6 I P N M T S N C Y G L W T L V D F L G 7

GPCRdb(A)
GPCRdb(A)
5-HT6 receptor
TM3
3x32 3.32x32 D106
3x33 3.33x33 V107
3x36 3.36x36 C110
3x37 3.37x37 S111
ECL2
45x52 45.52x52 L182
TM5
5x39 5.38x39 F188
5x43 5.42x43 A192
5x44 5.43x44 S193
TM6
6x48 6.48x48 W281
6x51 6.51x51 F284
6x52 6.52x52 F285
TM7
7x42 7.43x42 Y310